pain

I have seen some discussions here and there around the puzzling fact of muscle pain being a consequence of neural exhaustion, whatever that actually means in pathophysiology, but not within a formal thread. It's not quite clear how much distinction there is between PEM and PENE. Maybe they are...

https://www.efna.net/new-brain-mind-and-pain-book-of-evidence-released-for-the-2019-2024-eu-mandate/ Direct link to document (PDF), http://www.brainmindpain.eu/wp-content/uploads/2019/04/BMP-Book-of-Evidence-%E2%80%93-2019-2024-web.pdf

hi I have a very low dose of Lyrica aka Pregabalin for neuropathic pain which I get in hands and feet most noticeably at night. I had a bad experience with it when I first started taking it because I’m one of those who are knocked out by medications. I’ve stopped taking amitryptiline or...

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1456-x Personally I do not like this 'rat model' of CFS, I don't think there is anyway that they...

(List reported taken from the Mirror) full list here: note (ME not on list but FM is) https://www.cambridge-news.co.uk/news/uk-world-news/cambridge-migraine-endometriosis-arthritis-nhs-15339123

https://www.nytimes.com/2019/03/16/opinion/sunday/pain-opioids.html I saw this in the opinions today. It's a short read and I must say it is fluff. Summary: -The author notes that opioids have proven to be ineffective and even counterproductive for treating chronic pain (okay). -From that...

Pain is one of the symptoms frequently reported by patients. What are your experiences with CBD (Cannabidiol)? An article has appeared on the BBC website about the growing use of CBD in the UK. https://www.bbc.co.uk/programmes/articles/1v5vxpY7zkVkJLLSsvRXvqJ/why-is-cbd-on-everyones-lips

rest of details here: https://www.kcl.ac.uk/ioppn/news/records/2019/march/pioneering-pain-research-leads-to-landmark-deal (No CBT!)

Open access at https://www.degruyter.com/view/j/sjpain.2019.19.issue-1/sjpain-2018-2007/sjpain-2018-2007.xml

Thought this might be of interest. https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/kez027/5366191 Sci Hub, https://sci-hub.tw/https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/kez027/5366191

An objective biomarker - gene expression patterns - for pain? Can this be true? https://www.nature.com/articles/s41380-018-0345-5 (A.B Niculescu et al.) Full text. The cohorts and the scientists are psychiatric patients/psychiatrists but otherwise the study seems to lean more biomedical - not...

https://www.psychologytoday.com/us/blog/mindfulness-in-frantic-world/201902/mindfulness-could-be-powerful-painkiller Article doesn't mention CFS so far as I can see - just pain, mainly women. Given IAPT in UK (and MUS etc stuff) I thought this might be of interest.

Gender Bias in Pediatric Pain Assessment https://academic.oup.com/jpepsy/advance-article-abstract/doi/10.1093/jpepsy/jsy104/5273626?redirectedFrom=fulltext Journal of Pediatric Psychology, jsy104, https://doi.org/10.1093/jpepsy/jsy104 Brian D Earp et al, Published: 04 January 2019 (Paywall)...

From the press release: https://mcgill.ca/newsroom/channels/news/men-and-women-remember-pain-differently-293050 Based on this article: Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans Loren J. Martin et al, Published: January 10, 2019...

Relationship Between Exercise-induced Oxidative Stress Changes and Parasympathetic Activity in Chronic Fatigue Syndrome: An Observational Study and in Patients and Healthy Subjects Email the author MSc Andrea Polli,Jessica Van Oosterwijck, PhD,Jo Nijs, PhD, Uros Marusic, PhD,Inge De Wandele...

I'm still skeptical. It sounds like he is encouraging patients to hide their symptoms and behave more normally, and even a temporary change in that direction is taken as evidence that a mysterious mind-body illness was successfully treated. This is also not innovative. It's the same old...

https://www.csp.org.uk/frontline/article/childrens-pain-we-can-make-it-better links to FITNET another of NICE guidelines committee members.

Marieke Jepma, Leonie Koban, Johnny van Doorn, Matt Jones, Tor D. Wager. Behavioural and neural evidence for self-reinforcing expectancy effects on pain. Nature Human Behaviour, 2018; 2 (11): 838 DOI: 10.1038/s41562-018-0455-8 Link: https://www.nature.com/articles/s41562-018-0455-8 Abstract...

Paywalled at https://www.degruyter.com/view/j/sjpain.ahead-of-print/sjpain-2018-0095/sjpain-2018-0095.xml

Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies Polli A1, Van Oosterwijck J2,3, Meeus M3,4, Lambrecht L5, Nijs J6, Ickmans K6. Author information 1 Pain in...