pain

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...

This is disapointing… …"This implies that experience of trauma and distress might elicit a specific immune-biological response in genetically or otherwise (eg, past infection, toxicity, trauma) vulnerable individuals, which includes the production of harmful noninflammatory autoantibodies." …...

SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain Liu, Jin-Kun; Zhou, Zi-Su; Wang, Shu-Hang; Zuo, Shi-Yu; Lu, Xiao-Fan; He, Ying; Tang, Hao; Xie, Yan; Xie, Man-Xiu; Zhang, Xiao-Long Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome...

Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive Berwick, Richard J.; Sahbaie, Peyman; Kenny, Grace; Guo, Tian-Zhi; Neiland, Harvey; Andersson, David A.; Clark...

323 - Toxic Exposures and Chronic Overlapping Pain Conditions in a Veteran Cohort: Gender-Specific Insights from the Million Veteran Program Armand Gerstenberger, Niloofar Afari, Marianna Gasperi [Line breaks added] Chronic overlapping pain conditions (COPCs) include migraine, tension...

368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...

Highlights • Transplanting gut microbiota from women with fibromyalgia into mice induces pain • It also induces immune activation, metabolomic changes, and reduced skin innervation • Gut microbiota promotes pain through several mechanisms Summary Fibromyalgia is a prevalent syndrome...

Scientists pinpoint cause of migraines - paves way for new treatment

PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain Sbei, Sami; Moncrief, Taylor; Limjunyawong, Nathachit; Zeng, Yaping; Green, Dustin P. Migraine ranks among the most prevalent disorders worldwide, leading to disability and decreased quality of life in patients...

Abstract Background: This study aims to explore the perceptions and clinical approaches of pain management specialists toward myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition characterized by persistent fatigue, widespread pain, unrefreshing sleep, and autonomic...

Commonly used interventional procedures for non-cancer chronic spine pain: a clinical practice guideline Jason W Busse; Stéphane Genevay; Arnav Agarwal; Christopher J Standaert; Kevin Carneiro; Jason Friedrich; Manuela Ferreira; Hilde Verbeke; Jens Ivar Brox; Hong Xiao; Jasmeer Singh Virdee...

Abstract: Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...

The psychological and physiological effects of a virtual reality-based treatment program in female patients with fibromyalgia syndrome: A randomized controlled trial. Sari et al, 2025 Abstract The study aims to evaluate the effects of virtual reality (VR) programs on disease activity, central...

Abstract Objectives To summarize and evaluate Cochrane reviews of pharmacological therapies for adults with fibromyalgia syndrome (FMS) pain. Methods Systematic search of Cochrane Database of Systematic Reviews to May 2024. Generic quality assessment used AMSTAR-2 criteria, validity checks of...

This post has been copied and some following posts moved I don’t know how common it is, but chostochondritis is regularly reported in social media. With me it varies with my ME, and when I was at my worst the pain was one of my most disabling symptoms. Currently it is only there when I am in...

Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study Kiran Thapaliya; Sonya Marshall-Gradisnik; Natalie Eaton-Fitch; Markus Barth; Maira Inderyas; Leighton Barnden Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue...

Pain Coping Skills Training for Patients Receiving Hemodialysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2828284 Abstract Importance: Chronic pain is common among individuals with dialysis-dependent kidney failure. Objective: To evaluate the effectiveness of pain...

PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II Pinto; Vilar; McNaughton Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), and more recent studies have shown that...

Preprint Abstract Background: Sex differences have been widely demonstrated in both acute and chronic pain. Sex differences may have wider impact on research design and analysis than already established. This study addresses an important methodological aspect with regards to how sex differences...

Association Between Chronic Pain and Fatigue Severity with Weather and Air Pollution Among Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Chloe Lisette Jones, Olivia Haskin, Jarred Wayne Younger Abstract Weather and air quality conditions have been anecdotally...