pain

Neat1 lncRNA organizes the inflammatory gene expressions in the dorsal root ganglion in neuropathic pain caused by nerve injury Maruyama, Motoyo; Sakai, Atsushi; Fukunaga, Tsukasa; Miyagawa, Yoshitaka; Okada, Takashi; Hamada, Michiaki; Suzuki, Hidenori Primary sensory neurons regulate...

Identification and targeting of a unique NaV1.7 domain driving chronic pain Gomez, Kimberly; Stratton, Harrison J.; Duran, Paz; Loya, Santiago; Tang, Cheng; Calderon-Rivera, Aida; François-Moutal, Liberty; Khanna, May; Madura, Cynthia L.; Luo, Shizhen; McKiver, Bryan; Choi, Edward; Ran, Dongzhi...

The predictive role of pain catastrophising following genicular arterial embolisation for the treatment of mild and moderate knee osteoarthritis Richard Harrison; Tim Salomons; Sarah MacGill; Mark Little Knee osteoarthritis (OA) is the most common form of OA and is not currently considered to...

Highlights A group of trials with trust concerns had major impacts on the results of systematic reviews and clinical guidelines. They substantially impacted effect sizes and influenced the conclusions and recommendations drawn. There is a need for a greater focus on the trustworthiness of...

Free fulltext: https://www.mdpi.com/2072-6651/15/6/376 Outcomes of IncobotulinumtoxinA Injection on Myalgia and Arthralgia in Patients Undergoing Temporomandibular Joint Arthroscopy: A Randomized Controlled Trial by David Faustino Ângelo 1,2,3,4,*, David Sanz 1, Francesco Maffia 1,5and...

Abstract Neuropathic pain is a debilitating condition affecting around 8% of the adult population in the UK. The pathophysiology is complex and involves a wide range of processes, including alteration of neuronal excitability and synaptic transmission, dysregulated intracellular signalling and...

Post-COVID Patients With New-Onset Chronic Pain 2 Years After Infection: Cross-Sectional Study Andrés Calvache-Mateo; Alba Navas-Otero; Alejandro Heredia-Ciuró; Javier Matín-Núñez; Irene Torres-Sánchez; Laura López-López; Marie Carmen Valenza Background: Although pain is common in...

https://www.cochrane.org/CD014682/SYMPT_how-effective-are-antidepressants-used-treat-chronic-pain-and-do-they-cause-unwanted-effects Key messages • We are only confident in the effectiveness of one antidepressant: duloxetine. We found that a standard dose (60 mg) was effective, and that there...

The impact of fibromyalgia syndrome on obstructive sleep apnea syndrome in terms of pain threshold, daytime symptoms, anxiety, depression, disease severity, and sleep quality: a polysomnographic study Abstract Background Current studies have focused on the association of fibromyalgia syndrome...

https://www.cdc.gov/mmwr/volumes/72/wr/mm7215a1.htm Chronic Pain Among Adults — United States, 2019–2021 Weekly / April 14, 2023 / 72(15);379–385 Print S. Michaela Rikard, PhD1; Andrea E. Strahan, PhD1; Kristine M. Schmit, MD1; Gery P. Guy Jr., PhD1 (VIEW AUTHOR AFFILIATIONS) View suggested...

Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy Andelic, Mirna; Salvi, Erika; Marcuzzo, Stefania; Marchi, Margherita; Lombardi, Raffaella; Cartelli, Daniele; Cazzato, Daniele; Mehmeti, Elkadia; Gelemanovic, Andrea; Paolini, Matilde; Pardo...

Reduced MC4R signaling alters nociceptive thresholds associated with red hair Kathleen C. Robinson, Lajos V. Kemény, Gillian L. Fell, Andrea L. Hermann, Jennifer Allouche , Weihua Ding, Ajay Yekkirala, Jennifer J. Hsiao, Mack Y. Su, Nicholas Theodosakis , Gabor Kozak , Yuichi Takeuchi, Shiqian...

"Endometriosis is excruciating. But the medical scale for pain is tragically flawed, leaving women in particular to suffer On a scale of zero to 10, with zero being no pain at all and 10 being the worst pain imaginable, how is your pain? Because pain is impossible to diagnose objectively...

What has brain diffusion MRI taught us on chronic pain: a critical review Monica Sean, Graham Little, Paul Bautin, Marylie Martel, Maxime Descoteaux, Guillaume Leonard, Pascal Tetreault Chronic pain is a widespread health condition affecting millions of individuals worldwide. Despite its high...

https://archive.ph/oBHQQ Millions of patients will be offered help to come off antidepressants and painkillers under an NHS drive to tackle addiction to prescription pills. New national guidance urges GPs to stop writing repeat prescriptions for those who have become dependent on common...

I did not listen to this podcast. I’m flagging it because it’s a New York Times columnist and promoting a bps book, title of the column: this book changed my relationship to pain. https://www.nytimes.com/2023/02/21/opinion/17eks-ezra-klein-podcast-rachel-zoffness.html

https://link.springer.com/article/10.1007/s10067-014-2517-2 Open access Abstract Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that...

Abstract Background The role of cytokines in the pathophysiology, diagnosis, and prognosis of small fiber neuropathy (SFN) is incompletely understood. We studied expression profiles of selected pro- and anti-inflammatory cytokines in RNA from white blood cells (WBC) of patients with a medical...

I really wonder how Drs in can give prescriptions for Oramoph and Tramadol but not medical marijuana.... Does anyone have any thoughts? https://www.independent.co.uk/life-style/health-and-families/multiple-sclerosis-symptoms-hereditary-cause-b2239253.html

Patel KV, Amtmann D, Jensen MP, Smith SM, Veasley C, Turk DC. Clinical outcome assessment in clinical trials of chronic pain treatments. Pain Rep. 2021 Jan 21;6(1):e784. doi: 10.1097/PR9.0000000000000784. PMID: 33521482; PMCID: PMC7837993. Abstract Clinical outcome assessments (COAs) measure...