t-cells

  1. Dolphin

    Genetic study of T cell receptor (TCR) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), 2021, Ueland (Masters thesis)

    From: Dr. Marc-Alexander Fluks Source: University of Oslo Date: May 18 and June 21, 2021 URL: https://www.duo.uio.no/bitstream/handle/10852/87105/7/Ueland_MasterThesis_2021.pdf Ref: https://www.mn.uio.no/ibv/studier/aktuelt/mastereksamen/var-2021/marthe%20ueland.html Genetic study of...
  2. Andy

    Fine mapping of the major histocompatibility complex (MHC) in (ME/CFS) suggests involvement of both HLA class I and class II loci, 2021, Hajdarevic

    Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...
    • Andy
    • Thread
    • autoimmunity fluge genetics genomics hajdarevic hla hla-dqb1 immunology me/cfs mella mhc norway saugstad t-cells
    • Replies: 16
    • Forum: ME/CFS research
  3. Andy

    Long-term SARS-CoV-2-specific immune & inflammatory responses in individuals recovering from COVID-19 with & without post-acute symptoms, 2021, Peluso

    Highlights The magnitude of early CD4+ T cell responses correlates with severity of COVID-19 Prior lung disease correlates with higher SARS-CoV-2-specific CD8+ T cell responses PASC is associated with a decline in N-specific interferon-γ-producing CD8+ T cells Neutralizing capacity correlates...
    • Andy
    • Thread
    • 2021 interferon-y long covid paper symptoms t-cells
    • Replies: 0
    • Forum: Long Covid research
  4. J

    Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) ..., 2021, Patterson et al (in prep)

    https://www.biorxiv.org/content/10.1101/2021.06.25.449905v2 The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected...
    • Jaybee00
    • Thread
    • bruce patterson cx3cl1 fractalkine long covid monocytes post covid-19 syndrome t-cells
    • Replies: 15
    • Forum: ME/CFS research
  5. Andy

    Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses.., 2021, Gabriel et al

    Full title: Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection Highlights Tpex cells preserve mitochondrial fitness during chronic infection TGF-β-mediated mTOR-inhibition preserves metabolism in Tpex...
  6. rvallee

    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions, 2021

    Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...
  7. cassava7

    Selin Lab

    This post has been copied and following discussion moved from this thread: USA: NIH National Institute of Health The NIH has awarded a $2.5M R01 grant to Drs Liisa Selin and Anna Gil for their work on altered T cells in ME/CFS. This follows their 2019 Ramsay award from Solve ME with which they...
  8. leokitten

    Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. Files et al. JCI (2020)

    https://www.jci.org/articles/view/140491 ScienceDaily News piece on paper here Of particular interest to long COVID research is they found immune dysregulation in non-hospitalized patients didn’t resolve quickly as well as activation and exhaustion markers increased during the...
  9. W

    Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease (Jan2020) Gate, M.Davis & Wyss-Coray, Stanford)

    This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for targets for T-Cell expansion. For Alzheimer's they found TCR's responding to two separate Epstein–Barr virus antigens in CSF...
  10. Ravn

    Nature: Sex-specific adipose tissue imprinting of regulatory T cells (2020)

    Note: mice. Vasanthakumar, A., Chisanga, D., Blume, J. et al. Sex-specific adipose tissue imprinting of regulatory T cells. Nature (2020). https://doi.org/10.1038/s41586-020-2040-3 https://www.nature.com/articles/s41586-020-2040-3 (paywalled) Article about paper: Sex-specific traits of the...
  11. Sly Saint

    T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives - Banfi, Diani et al Feb 2020

    https://www.mdpi.com/1422-0067/21/4/1186
  12. J

    Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo (2020) Nixon et al

    https://www.nature.com/articles/s41586-020-1951-3 Only in mice and monkeys but quite interesting that they are flushing out a latent virus. And great if they can use it to eliminate HIV as well, of course.
  13. Dolphin

    An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline, 2019, Conroy et al

    Possibly of interest, given how many patients can be on these types of drugs. Though I don't really understand what the implications might be myself without reading the full paper. https://www.sciencedirect.com/science/article/abs/pii/S0924977X1931870X
  14. R

    ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

    https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions...
    • Ron
    • Thread
    • cornell university cytokines immune challenge immunology mandarano maureen hanson me/cfs t-cells
    • Replies: 28
    • Forum: ME/CFS research
  15. rvallee

    First evidence of immune response targeting brain cells in autism

    Preliminary but interesting. Autism has been researched far more than ME and somehow this had been missed entirely. I would really like to see research done on post-mortem ME brains and spinal cords. This is the reason the researchers named this disease and there doesn't seem to have been any...
  16. Cheshire

    ME/CFS as a hyper-regulated immune system driven by an interplay between regulatory T cells & chronic human herpesvirus infections (2019) Nacul et al.

    Nuno Sepúlveda, Jorge Carneiro, Eliana M. Lacerda and Luis C. Nacul https://www.frontiersin.org/articles/10.3389/fimmu.2019.02684/abstract Study made with the UK ME/CFS Biobank Full text not available yet, will be published soon.
    • Cheshire
    • Thread
    • 2019 ebv herpesvirus me/cfs nacul paper sepulveda t-cells
    • Replies: 32
    • Forum: ME/CFS research
  17. Dolphin

    Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

    Somebody with ME was excited by this on Twitter https://insight.jci.org/articles/view/124714 Research ArticleClinical trialsNeuroscience Free access | 10.1172/jci.insight.124714 Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis Michael P. Pender,1,2,3 Peter A...
  18. Andy

    Associations between clinical symptoms, plasma norepinephrine & deregulated immune gene networks in subgroups of adolescent w/CFS, 2018, Nguyen et al

    Paywalled at https://www.sciencedirect.com/science/article/pii/S0889159118307967?via%3Dihub
    • Andy
    • Thread
    • 2018 genetics immunology me/cfs nguyen norepinephrine paper t-cells young people
    • Replies: 3
    • Forum: ME/CFS research
  19. Andy

    Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation, 2018, Unutmaz et al

    Paywalled at https://www.nature.com/articles/s41385-018-0072-x While this is in "Unrelated to ME/CFS research" forum, the blog below, from Jackson Labs, suggests that it could have some implication in ME. https://jaxmecfs.com/2018/09/24/750/
  20. M

    Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing (2018)

    Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing Dr Unutmaz is one of the principal investigator of this paper. http://www.jimmunol.org/content/early/2018/07/18/jimmunol.1701616?papetoc Abstract: Abstract Developing precise and efficient gene editing approaches...
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