Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests...
Highlights The magnitude of early CD4+ T cell responses correlates with severity of COVID-19 Prior lung disease correlates with higher...
https://www.biorxiv.org/content/10.1101/2021.06.25.449905v2 The recent COVID-19 pandemic is a treatment challenge in the acute infection stage...
Full title: Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic...
Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration...
This post has been copied and following discussion moved from this thread: USA: NIH National Institute of Health The NIH has awarded a $2.5M R01...
https://www.jci.org/articles/view/140491 SARS-CoV-2 causes a wide spectrum of clinical manifestations and significant mortality. Studies...
This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for...
Note: mice. Vasanthakumar, A., Chisanga, D., Blume, J. et al. Sex-specific adipose tissue imprinting of regulatory T cells. Nature (2020)....
Abstract Fibromyalgia is one of the most important “rheumatic” disorders, after osteoarthritis. The etiology of the disease is still not clear. At...
Abstract Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can...
Possibly of interest, given how many patients can be on these types of drugs. Though I don't really understand what the implications might be...
https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs New findings published in the Journal of...
In a paper published in Annals of Neurology, Matthew Anderson, HMS associate professor of pathology at Beth Israel Deaconess Medical Center, and...
Nuno Sepúlveda, Jorge Carneiro, Eliana M. Lacerda and Luis C. Nacul Autoimmunity and chronic viral infections are recurrent clinical observations...
Somebody with ME was excited by this on Twitter https://insight.jci.org/articles/view/124714 Research ArticleClinical trialsNeuroscience Free...
Highlights • 29 deregulated immune gene sets were identified to distinguish patients and controls; as well as delineate patients into two...
Abstract Human mucosal-associated invariant T (MAIT) cell receptors (TCRs) recognize bacterial riboflavin pathway metabolites through the MHC...
Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing Dr Unutmaz is one of the principal investigator of this paper....
Obviously based on results from mice, so take any claims with a pinch of salt. Significance Epidemiological studies have shown a correlation...
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