1. Guest, the 'News in Brief' for the week beginning 16th November 2020 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice
  3. Guest, NICE have published their draft guideline for ME/CFS, click here to read about it.
    Dismiss Notice

ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

Discussion in 'BioMedical ME/CFS Research' started by Ron, Dec 12, 2019.

  1. Ron

    Ron Established Member (Voting Rights)

    Messages:
    88
    Likes Received:
    823
    https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs

    New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy. The research was supported by the National Institutes of Health.

    “This research gives us additional evidence for the role of the immune system in ME/CFS and may provide important clues to help us understand the mechanisms underlying this devastating disease,” said Vicky Whittemore, Ph.D., program director at NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which partially funded the study.
     
  2. Kalliope

    Kalliope Senior Member (Voting Rights)

    Messages:
    3,550
    Likes Received:
    36,004
    Location:
    Norway
  3. Andy

    Andy Committee Member & Outreach

    Messages:
    11,142
    Likes Received:
    80,628
    Location:
    Hampshire, UK
    Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
    Open access, https://www.jci.org/articles/view/132185
     
  4. John Mac

    John Mac Senior Member (Voting Rights)

    Messages:
    337
    Likes Received:
    4,073
    Talk given on this paper is now on Youtube

     
  5. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

    Messages:
    556
    Likes Received:
    2,443
    Ok but how does this altered T cell metabolism affect brain stem function as shown in other research?
     
  6. strategist

    strategist Senior Member (Voting Rights)

    Messages:
    3,167
    Likes Received:
    31,860
    I suspect the so far few responses to this are due to this being a very technical paper, packed with information and findings.

     
    spinoza577, Caesar, merylg and 6 others like this.
  7. Forbin

    Forbin Senior Member (Voting Rights)

    Messages:
    1,214
    Likes Received:
    8,827
    From the video:

     
    spinoza577, chrisb, DokaGirl and 8 others like this.
  8. DigitalDrifter

    DigitalDrifter Senior Member (Voting Rights)

    Messages:
    329
    Likes Received:
    1,922
    What was that Wessely said about a little less t-cells and a little more psychology?
     
    chrisb, DokaGirl, merylg and 9 others like this.
  9. beverlyhills

    beverlyhills Established Member (Voting Rights)

    Messages:
    90
    Likes Received:
    272
    Is Maureen Hanson a member of this board?

    Why wouldn't sedentary individuals have reduced glycolysis in their T-cells?

    Ambulatory individuals would have higher creatine kinase, which in turn improve T-cell function, and that is just one pathway, there are dozens more that explain this.

    And how is this finding helpful, if I explained it one sentence.
     
    Simone, Sid, DokaGirl and 1 other person like this.
  10. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Messages:
    5,340
    Likes Received:
    44,358
    Location:
    UK
    article
    ME and Chronic Fatigue Syndrome Linked to Immune Cell Changes
    https://www.technologynetworks.com/...syndrome-linked-to-immune-cell-changes-328427
     
  11. Pondering

    Pondering Established Member

    Messages:
    13
    Likes Received:
    37
    Is it though? So many people have looked for this and found anything. I am wondering if there is not some other mechanism at work. Look at the recent finding that measles has a long term impact on the immune system. Recent research seems to be providing the idea that the virus might not need to still be there.
     
  12. rvallee

    rvallee Senior Member (Voting Rights)

    Messages:
    5,137
    Likes Received:
    40,736
    Location:
    Canada
    Always a good rule of thumb to do the opposite of what he thinks is a good idea. Holds up perfectly so far.
     
    ScottTriGuy, Sean, merylg and 2 others like this.
  13. Badpack

    Badpack Established Member (Voting Rights)

    Messages:
    72
    Likes Received:
    250
    "We found that ME/CFS CD8+ T cells have reduced mitochondrial membrane potential compared to healthy controls."

    That even further makes me want to finally try out elamipretide.
     
    merylg and ScottTriGuy like this.
  14. ScottTriGuy

    ScottTriGuy Senior Member (Voting Rights)

    Messages:
    662
    Likes Received:
    5,983
    Location:
    Toronto
    Sounds like you've been following its development - did they publish the phase 3 results?
     
  15. Badpack

    Badpack Established Member (Voting Rights)

    Messages:
    72
    Likes Received:
    250
    @ScottTriGuy Data collection ends this year. Early next year is the meeting they said for a possible publication. With Alexion they also found a distributor. Seems like a possible 2020 availability.
     
  16. Ravn

    Ravn Senior Member (Voting Rights)

    Messages:
    1,174
    Likes Received:
    9,924
    The video is really good. I recommend watching it before trying to digest the paper itself, which is rather technical.

    What I'm still trying to get my head around is this. On the one hand they say:
    On the other hand they find:
    So if the cytokines are the same in ME and HC but there are different correlations between cytokines and metabolism it has to be the metabolism that's skewed? And because the metabolism is skewed even normal levels of cytokines have weird effects? Or have I got that completely wrong?
     
    spinoza577, obeat, ukxmrv and 11 others like this.
  17. fds

    fds Established Member (Voting Rights)

    Messages:
    91
    Likes Received:
    812
    I thought this was a good presentation and as @Ravn said above it does help with understanding the paper
     
    Anna H, Ravn, Ron and 1 other person like this.
  18. lansbergen

    lansbergen Senior Member (Voting Rights)

    Messages:
    616
    Likes Received:
    2,246
  19. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Messages:
    5,340
    Likes Received:
    44,358
    Location:
    UK
    another article
    Study finds differences in energy use by immune cells in ME/CFS
    https://www.mlo-online.com/molecula...rences-in-energy-use-by-immune-cells-in-mecfs
     
    spinoza577, Michelle, Ravn and 4 others like this.
  20. lansbergen

    lansbergen Senior Member (Voting Rights)

    Messages:
    616
    Likes Received:
    2,246
    spinoza577, Ravn, Ron and 2 others like this.

Share This Page