ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

Discussion in 'ME/CFS research' started by Ron, Dec 12, 2019.

  1. Ron

    Ron Established Member (Voting Rights)

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    https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs

    New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy. The research was supported by the National Institutes of Health.

    “This research gives us additional evidence for the role of the immune system in ME/CFS and may provide important clues to help us understand the mechanisms underlying this devastating disease,” said Vicky Whittemore, Ph.D., program director at NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which partially funded the study.
     
  2. Kalliope

    Kalliope Senior Member (Voting Rights)

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  3. Andy

    Andy Committee Member

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    Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations
    Open access, https://www.jci.org/articles/view/132185
     
  4. John Mac

    John Mac Senior Member (Voting Rights)

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  5. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Ok but how does this altered T cell metabolism affect brain stem function as shown in other research?
     
  6. Hoopoe

    Hoopoe Senior Member (Voting Rights)

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    I suspect the so far few responses to this are due to this being a very technical paper, packed with information and findings.

     
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  7. Forbin

    Forbin Senior Member (Voting Rights)

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    From the video:

     
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  8. DigitalDrifter

    DigitalDrifter Senior Member (Voting Rights)

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    What was that Wessely said about a little less t-cells and a little more psychology?
     
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  9. beverlyhills

    beverlyhills Established Member (Voting Rights)

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    Is Maureen Hanson a member of this board?

    Why wouldn't sedentary individuals have reduced glycolysis in their T-cells?

    Ambulatory individuals would have higher creatine kinase, which in turn improve T-cell function, and that is just one pathway, there are dozens more that explain this.

    And how is this finding helpful, if I explained it one sentence.
     
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  10. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    article
    ME and Chronic Fatigue Syndrome Linked to Immune Cell Changes
    https://www.technologynetworks.com/...syndrome-linked-to-immune-cell-changes-328427
     
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  11. Pondering

    Pondering Established Member

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    Is it though? So many people have looked for this and found anything. I am wondering if there is not some other mechanism at work. Look at the recent finding that measles has a long term impact on the immune system. Recent research seems to be providing the idea that the virus might not need to still be there.
     
  12. rvallee

    rvallee Senior Member (Voting Rights)

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    Always a good rule of thumb to do the opposite of what he thinks is a good idea. Holds up perfectly so far.
     
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  13. Badpack

    Badpack Established Member (Voting Rights)

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    "We found that ME/CFS CD8+ T cells have reduced mitochondrial membrane potential compared to healthy controls."

    That even further makes me want to finally try out elamipretide.
     
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  14. ScottTriGuy

    ScottTriGuy Senior Member (Voting Rights)

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    Sounds like you've been following its development - did they publish the phase 3 results?
     
  15. Badpack

    Badpack Established Member (Voting Rights)

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    @ScottTriGuy Data collection ends this year. Early next year is the meeting they said for a possible publication. With Alexion they also found a distributor. Seems like a possible 2020 availability.
     
  16. Ravn

    Ravn Senior Member (Voting Rights)

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    The video is really good. I recommend watching it before trying to digest the paper itself, which is rather technical.

    What I'm still trying to get my head around is this. On the one hand they say:
    On the other hand they find:
    So if the cytokines are the same in ME and HC but there are different correlations between cytokines and metabolism it has to be the metabolism that's skewed? And because the metabolism is skewed even normal levels of cytokines have weird effects? Or have I got that completely wrong?
     
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  17. fds

    fds Established Member (Voting Rights)

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  18. lansbergen

    lansbergen Senior Member (Voting Rights)

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  19. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    another article
    Study finds differences in energy use by immune cells in ME/CFS
    https://www.mlo-online.com/molecula...rences-in-energy-use-by-immune-cells-in-mecfs
     
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  20. lansbergen

    lansbergen Senior Member (Voting Rights)

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