ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

https://www.nih.gov/news-events/news-releases/study-finds-differences-energy-use-immune-cells-me/cfs

New findings published in the Journal of Clinical Investigation suggest that specific immune T cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) show disruptions in the way they produce energy. The research was supported by the National Institutes of Health.

“This research gives us additional evidence for the role of the immune system in ME/CFS and may provide important clues to help us understand the mechanisms underlying this devastating disease,” said Vicky Whittemore, Ph.D., program director at NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which partially funded the study.

 

Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations

Open access, https://www.jci.org/articles/view/132185

 

Talk given on this paper is now on Youtube

 

Ok but how does this altered T cell metabolism affect brain stem function as shown in other research?

 

I suspect the so far few responses to this are due to this being a very technical paper, packed with information and findings.

 

From the video:

 

What was that Wessely said about a little less t-cells and a little more psychology?

 

Is Maureen Hanson a member of this board?

Why wouldn't sedentary individuals have reduced glycolysis in their T-cells?

Ambulatory individuals would have higher creatine kinase, which in turn improve T-cell function, and that is just one pathway, there are dozens more that explain this.

And how is this finding helpful, if I explained it one sentence.

 

article
ME and Chronic Fatigue Syndrome Linked to Immune Cell Changes

https://www.technologynetworks.com/...syndrome-linked-to-immune-cell-changes-328427

 

Is it though? So many people have looked for this and found anything. I am wondering if there is not some other mechanism at work. Look at the recent finding that measles has a long term impact on the immune system. Recent research seems to be providing the idea that the virus might not need to still be there.

 

Always a good rule of thumb to do the opposite of what he thinks is a good idea. Holds up perfectly so far.

 

"We found that ME/CFS CD8+ T cells have reduced mitochondrial membrane potential compared to healthy controls."

That even further makes me want to finally try out elamipretide.

 

Sounds like you've been following its development - did they publish the phase 3 results?

 

@ScottTriGuy Data collection ends this year. Early next year is the meeting they said for a possible publication. With Alexion they also found a distributor. Seems like a possible 2020 availability.

 

The video is really good. I recommend watching it before trying to digest the paper itself, which is rather technical.

What I'm still trying to get my head around is this. On the one hand they say:

On the other hand they find:

So if the cytokines are the same in ME and HC but there are different correlations between cytokines and metabolism it has to be the metabolism that's skewed? And because the metabolism is skewed even normal levels of cytokines have weird effects? Or have I got that completely wrong?

 

I thought this was a good presentation and as @Ravn said above it does help with understanding the paper

 

https://www.immunology.org/public-information/bitesized-immunology/cells/cd8-t-cells

CD8+ T Cells

 

another article
Study finds differences in energy use by immune cells in ME/CFS

https://www.mlo-online.com/molecula...rences-in-energy-use-by-immune-cells-in-mecfs

 

Maybe clues can be found in the TSE literature.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149501/

However, these CD4 and CD8 T cells are defective in such an effector function(s) as IFN-γ and TNF-α expression or release or lytic activity.