Long-term SARS-CoV-2-specific immune & inflammatory responses in individuals recovering from COVID-19 with & without post-acute symptoms, 2021, Peluso

Highlights

• The magnitude of early CD4+ T cell responses correlates with severity of COVID-19
• Prior lung disease correlates with higher SARS-CoV-2-specific CD8+ T cell responses
• PASC is associated with a decline in N-specific interferon-γ-producing CD8+ T cells
• Neutralizing capacity correlates with SARS-CoV-2-specific CD4+ T cell responses

Summary

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses, soluble markers of inflammation, and antibody levels and neutralization capacity longitudinally in 70 individuals with PCR-confirmed SARS-CoV-2 infection. Participants represent a spectrum of illness and recovery, including some with persistent viral shedding in saliva and many experiencing post-acute sequelae of SARS-CoV-2 infection (PASC). T cell responses remain stable for up to 9 months. Whereas the magnitude of early CD4+ T cell immune responses correlates with severity of initial infection, pre-existing lung disease is independently associated with higher long-term SARS-CoV-2-specific CD8+ T cell responses. Among participants with PASC 4 months following coronavirus disease 2019 (COVID-19) symptom onset, we observe a lower frequency of CD8+ T cells expressing CD107a, a marker of degranulation, in response to Nucleocapsid (N) peptide pool stimulation, and a more rapid decline in the frequency of N-specific interferon-γ-producing CD8+ T cells. Neutralizing antibody levels strongly correlate with SARS-CoV-2-specific CD4+ T cell responses.

Open access, https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00948-7