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Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. Files et al. JCI (2020)

Discussion in 'Epidemics (including Covid-19)' started by leokitten, Dec 29, 2020.

  1. leokitten

    leokitten Senior Member (Voting Rights)

    ScienceDaily News piece on paper here

    Of particular interest to long COVID research is they found immune dysregulation in non-hospitalized patients didn’t resolve quickly as well as activation and exhaustion markers increased during the convalescent post infection time period.
    Last edited: Dec 30, 2020
    Simon M, Forbin, shak8 and 9 others like this.
  2. mat

    mat Senior Member (Voting Rights)

    Presumably, B lymphocytes would become the latent reservoir of SARS-CoV-2. Similar to EBV, SARS-CoV-2 has an immune suppression phase (10.1038/s41467-020-19706-9). This is the reason why B lymphocytes wouldn't be affected while other mediators of the immune system decline. Both viruses interfere with interferon signaling (10.1146/annurev-micro-020518-115759). The same immune suppression pathology could persist locally on cellular levels in long haulers. If the immune-suppressive pathology could be suppressed, the virus probably couldn't even reach the lungs during the incubation phase and induce ARDS later on. Spread would also be affected since there would be no asymptomatic incubation and unnoticed spreading.
  3. Grigor

    Grigor Senior Member (Voting Rights)

    Exciting study!
    MEMarge likes this.

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