t cells

  1. John Mac

    Tevogen Bio to investigate T cell therapy in long Covid

    Tevogen Bio is set to study the potential therapeutic use of its investigational Covid-19 T cell therapy, TVGN-489, in long Covid. The finding that none of the patients in the TVGN 489 proof-of-concept (POC) trial, treated for their initial Covid infection, developed long Covid to date is...
  2. cassava7

    Phenotypic characteristics of peripheral immune cells of ME/CFS via transmission electron microscopy: A pilot study, Jahanbani et al, 2022

    Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022 — Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...
    • cassava7
    • Thread
    • electron microscopy immune dysfunction lipid droplets lipid metabolism lipids mitochondria mitochondrial architecture omf open medicine foundation ron davis smpd1 sphingolipids t cells
    • Replies: 25
    • Forum: ME/CFS research
  3. SNT Gatchaman

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children, 2022, Buonsenso et al

    Recovering or Persisting: The Immunopathological Features of SARS-CoV-2 Infection in Children Buonsenso D, Valentini P, De Rose C, Tredicine M, Pereyra Boza MdC, Camponeschi C, Morello R, Zampino G, Brooks AES, Rende M, Ria F, Sanguinetti M, Delogu G, Sali M, Di Sante G, on behalf of the...
    • SNT Gatchaman
    • Thread
    • children covid-19 immune dysfunction immunology innate immune system long covid t cells
    • Replies: 2
    • Forum: Long Covid research
  4. SNT Gatchaman

    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology, 2022, Hejbøl et al

    Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...
    • SNT Gatchaman
    • Thread
    • agergaard inflammation long covid microcirculation mitochondrial dysfunction muscle muscle biopsy myopathy pxdn study idea t cells
    • Replies: 8
    • Forum: Long Covid research
  5. SNT Gatchaman

    Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers, 2022

    Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...
  6. Sean

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2, 2021, Leo Swadling et al

    Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 Leo Swadling, et al. Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells...
  7. leokitten

    Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19, 2021, Lee et al

    Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...
  8. J

    Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning Patterson et al. 2021

    https://www.frontiersin.org/articles/10.3389/fimmu.2021.700782/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being...
    • Jaybee00
    • Thread
    • bruce patterson ifny il-2 immunology interferon long covid post covid-19 syndrome t cells vegf
    • Replies: 2
    • Forum: ME/CFS research
  9. Marky

    The possibility of autoimmunity or auto-reactivity in ME/CFS

    This thread was split from Open Medicine Foundation (OMF) News I thought we could not conclude autoimmunity is likely out of the picture as long as we dont know how to target long lived plasma cells? I mean b-cells dont really matter at that point if im not mistanken, as the autoimmune plasma...
  10. Andy

    Brain astrocytes & microglia express functional MR1 molecules that present microbial antigens to ... (MAIT) cells, 2020, Priya et al

    Full title: Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells Paywall, https://www.jni-journal.com/article/S0165-5728(20)30689-5/fulltext Sci hub, https://sci-hub.se/10.1016/j.jneuroim.2020.577428
  11. Andy

    Immunometabolic profiling of T cells from .. relapsing-remitting [MS] .. impairment in glycolysis and mitochondrial respiration, 2017, Matarese et al

    Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
  12. Andy

    Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells, 2020, Campbell et al

    Paywall, https://www.nature.com/articles/s41586-020-2193-0 Sci hub, https://sci-hub.tw/10.1038/s41586-020-2193-0
  13. R

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity risk variants are more frequent in patients with ITO ME/CFS. This finding provides further evidence that there is a genetic...
    • Ron
    • Thread
    • 2020 autoimmunity b cells genetics me/cfs paper pathogenesis scheibenbogen steiner t cells
    • Replies: 10
    • Forum: ME/CFS research
  14. Dolphin

    Role of immune responses, focussing on herpes virus specificity and interferon-gamma, in Myocardial Infarction with reperfusion & in CFS, 2019, Murali

    • Dolphin
    • Thread
    • 2019 cmv cytokines ebv herpesvirus me/cfs murali myocardial paper t cells
    • Replies: 0
    • Forum: ME/CFS research
  15. Sly Saint

    BIOMARKER FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS) - Yamamoto et al 27 Feb 2020

    https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020040210&tab=PCTBIBLIO (main paper in japanese)
    • Sly Saint
    • Thread
    • 2020 b cells biomarker iggr me/cfs paper t cells yamamoto
    • Replies: 6
    • Forum: ME/CFS research
  16. Andy

    T cell immunomodulation by bile acid metabolites, 2020, Giovannini et al

    A short review/opinion piece. Paywall, https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.14223 Sci hub, https://sci-hub.se/10.1111/all.14223 @mariovitali , another one that will probably interest you. :)
  17. Sly Saint

    Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations - [new article 2020]

    Basal glycolysis is reduced in ME/CFS CD4+ T cells. https://www.jci.org/articles/view/132185/figure/4 paper from December 2019 https://www.jci.org/articles/view/132185 new Article by Mady Hornig https://www.jci.org/articles/view/134985
    • Sly Saint
    • Thread
    • 2020 article cytokines glycolysis hornig me/cfs metabolism paper t cells
    • Replies: 5
    • Forum: ME/CFS research
  18. Andy

    Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis, 2019, Song et al

    In mice. Paywall, https://www.nature.com/articles/s41586-019-1865-0 Sci hub, https://sci-hub.se/10.1038/s41586-019-1865-0 ETA: Added "In mice".
  19. Andy

    Bile acid metabolites control TH17 and Treg cell differentiation, 2019, Hang et al

    In mice. Paywall, https://www.nature.com/articles/s41586-019-1785-z Sci hub, https://sci-hub.se/10.1038/s41586-019-1785-z
  20. Hoopoe

    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    Moderator note: See this post in the thread for the preprint.
    • Hoopoe
    • Thread
    • 2019 biomarker intestinal permeability jackson labs leaky gut mait cells me/cfs microbiome paper t cells unutmaz zonulin
    • Replies: 90
    • Forum: ME/CFS research
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