Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID, 2023, Wang et al

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID
Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart; Vinay Prasad; Gavin Y. Oudit

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences.

We obtain plasma samples from 117 individuals during and 6 months following their acute phase of infection to comprehensively profile and assess changes in cytokines, proteome, and metabolome. Network analysis reveals sustained inflammatory response, platelet degranulation, and cellular activation during convalescence accompanied by dysregulation in arginine biosynthesis, methionine metabolism, taurine metabolism, and tricarboxylic acid (TCA) cycle processes. Furthermore, we develop a prognostic model composed of 20 molecules involved in regulating T cell exhaustion and energy metabolism that can reliably predict adverse clinical outcomes following discharge from acute infection with 83% accuracy and an area under the curve (AUC) of 0.96.

Our study reveals pertinent biological processes during convalescence that differ from acute infection, and it supports the development of specific therapies and biomarkers for patients suffering from long COVID.

Highlights

Sequential multi-omics profiling of plasma during acute infection and convalescence
Inflammation, platelet degranulation, and metabolic perturbations at convalescence
Three distinct disease phenotypes based on unsupervised clustering of omics profile
A panel of 20 cytokines and metabolites predicted adverse outcomes after discharge

Link | PDF (Cell Reports Medicine)

 

(Not that Vinay Prasad)

Hospitalised patients: ward (97) and ICU (20), during admission and 6 months later, vs HCs.

 

Noting: "Moreover, serotonin levels remained elevated in acute and convalescence phases, with even higher levels in convalescence".

Opposite to Serotonin reduction in post-acute sequelae of viral infection (2023, Cell). Also here, HCs are 0 µmol/L.

 

Haha, I actually saw this paper yesterday but gave up when I saw the name Vinay Prasad. Thanks for clearing that up

 

Different measurement methods? Because otherwise damn what a mess. Actually, what a huge mess either way. This feels like chemistry before they got basic stuff like reliable thermometers with standard scales.