serotonin

  1. SNT Gatchaman

    A cellular basis for heightened gut sensitivity in females, 2025, Venkataraman et al.

    A cellular basis for heightened gut sensitivity in females Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...
  2. John Mac

    Review Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2026, Wirth & Scheibenbogen

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID-19 syndrome share a symptom profile, including severe fatigue, cognitive dysfunction, exertional intolerance, sleep disturbances, hypervigilance, and the paradoxical state of being “wired but tired.” A...
    • John Mac
    • Thread
    • autonomic dysfunction gaba glutamate hypersensitivity me/cfs neurotransmitter imbalance noradrenaline scheibenbogen serotonin wirth
    • Replies: 5
    • Forum: ME/CFS research
  3. leokitten

    IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness, Yang et al, 2025

    Highlights • IL-1β uniquely triggers self-imposed social withdrawal during inflammation • IL-1R1-positive DRN serotonergic neurons mediate social withdrawal • A peripheral-to-central IL-1β relay sustains prolonged social withdrawal Summary Sick animals exhibit behavioral changes that extend...
  4. SNT Gatchaman

    Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation, 2025, Moretti et al.

    Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional...
  5. SNT Gatchaman

    Associations of selective serotonin reuptake inhibitors and long COVID risk in patients with depression: a retrospective cohort study, 2025, Gao et al

    Associations of selective serotonin reuptake inhibitors and long COVID risk in patients with depression: a retrospective cohort study PURPOSE To evaluate the potential of selective serotonin reuptake inhibitors (SSRIs) in reducing the risk of long COVID in patients with depression. METHODS...
  6. SNT Gatchaman

    Heightened innate immunity may trigger chronic inflammation, fatigue and [PEM]…, 2025, Che, Hornig, Bateman, Klimas, Komaroff, Lipkin+

    Link to published paper here Preprint: Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive...
    • SNT Gatchaman
    • Thread
    • amino acids calcium complement copper extracellular matrix fatty acid metabolism fatty acid oxidation gdf15 gut microbiome herv innate immune system integrins interferon gamma kynurenine lipid metabolism lipids metabolism pem serotonin tryptophan vegf
    • Replies: 48
    • Forum: ME/CFS research
  7. forestglip

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome], 2025, Valencia-Gutiérrez et al

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome] María Magdalena Valencia-Gutiérrez , Modesto Gómez-López, Nadia Mabel Pérez-Vielma, Paulina Lázaro-Aguilar, Víctor Ricardo Aguilera-Sosa Background Post-COVID-19 syndrome occurs 3 months after...
  8. Yann04

    Trazodone for Insomnia

    Trazodone has often been prescribed of label at a low dose for insomnia. It's primary use however is an SSRI antidepressant. Trazodone is the most effective insomnia treatment I've ever tried. It really helped my sleep for a couple months until I had to discontinue it a year and a half ago due...
  9. forestglip

    Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in [CFS], 2009, Ortega-Hernandez et al

    Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome Oscar-Danilo Ortega-Hernandez, Mariaclara Cuccia, Sara Bozzini, Nicola Bassi, Samuel Moscavitch, Lina-Marcela Diaz-Gallo, Miri Blank, Nancy Agmon-Levin, Yehuda...
    • forestglip
    • Thread
    • age of onset antineuronal cell antibodies arthralgia autoantibodies fever hla me/cfs myalgia serotonin serotonin receptor-2a gene serotonin transporter gene
    • Replies: 0
    • Forum: ME/CFS research
  10. SNT Gatchaman

    No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19, 2024, Mathé et al.

    No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19 Mathé, Philipp; Götz, Veronika; Stete, Katarina; Walzer, Dietrich; Hilger, Hanna; Pfau, Stefanie; Hofmann, Maike; Rieg, Siegbert; Kern, Winfried V. PURPOSE Approximately 10–20% of patients previously infected...
  11. SNT Gatchaman

    The germline coordinates mitokine signaling, 2024, Shen et al.

    The germline coordinates mitokine signaling Koning Shen; Jenni Durieux; Cesar G. Mena; Brant M. Webster; C. Kimberly Tsui; Hanlin Zhang; Larry Joe; Kristen M. Berendzen; Andrew Dillin The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C...
  12. forestglip

    Review Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder, 2024, Page et al

    Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder Chloe E. Page, C. Neill Epperson, Andrew M. Novick, Korrina A. Duffy, Scott M. Thompson Abstract The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has...
  13. E

    CROI - Conference on Retroviruses and Opportunistic Infections

    CROI - Conference on Retroviruses and Opportunistic Infections At this years CROI conference there were some presentations on Long-COVID (videos can be found at https://www.croiwebcasts.org/portal/ by using search terms such as "Long-Covid" or "post-acute"). There were also presentations of...
  14. SNT Gatchaman

    Clearance of gut mucosal SARS-CoV-2 antigens and post-acute COVID-19 after two years in patients with inflammatory bowel disease, 2024, Zollner et al.

    Clearance of gut mucosal SARS-CoV-2 antigens and post-acute COVID-19 after two years in patients with inflammatory bowel disease Andreas Zollner; Robert Koch; Almina Jukic; Alexandra Pfister; Moritz Meyer; Nikolaus Wick; Georg Wick; Annika Rössler; Janine Kimpel; Timon E. Adolph; Herbert Tilg...
  15. SNT Gatchaman

    Opinion Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration, 2024, Anderson et al.

    Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration George M Anderson; Edwin H Cook; Randy D Blakely; James S Sutcliffe; Jeremy Veenstra-VanderWeele We believe there are serious problems with a recently published and highly publicized paper entitled “Serotonin reduction in...
  16. SNT Gatchaman

    Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets, 2024, Hagn et al.

    Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets Gerhard Hagn; Samuel M. Meier-Menches; Günter Plessl-Walder; Gaurav Mitra; Thomas Mohr; Karin Preindl; Andreas Schlatter; Doreen Schmidl; Christopher Gerner; Gerhard Garhöfer; Andrea Bileck...
  17. SNT Gatchaman

    Assessing the effect of selective serotonin reuptake inhibitors in the prevention of post-acute sequelae of COVID-19, 2024, Sidky et al.

    Assessing the effect of selective serotonin reuptake inhibitors in the prevention of post-acute sequelae of COVID-19 Hythem Sidky; Kristen A. Hansen; Andrew T. Girvin; Nathan Hotaling; Sam G. Michael; Ken Gersing; David K. Sahner BACKGROUND Post-acute sequelae of COVID-19 (PASC) produce...
  18. SNT Gatchaman

    Treatment of 95 post-Covid patients with SSRIs, 2023, Rus et al.

    Treatment of 95 post-Covid patients with SSRIs Rus, Carla P.; de Vries, Bert E. K.; de Vries, Ingmar E. J.; Nutma, Idelette; Kooij, J. J. Sandra After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms indicate numerous affected organ systems. After a year, chronic fatigue...
  19. SNT Gatchaman

    Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID, 2023, Wang et al

    Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID Kaiming Wang; Mobin Khoramjoo; Karthik Srinivasan; Paul M.K. Gordon; Rupasri Mandal; Dana Jackson; Wendy Sligl; Maria B. Grant; Josef M. Penninger; Christoph H. Borchers; David S. Wishart...
    • SNT Gatchaman
    • Thread
    • arginine long covid metabolic methionine multi-omics platelets serotonin t cells taurine
    • Replies: 4
    • Forum: Long Covid research
  20. Hutan

    Metabolic rewiring and serotonin depletion in patients with postacute sequelae of COVID-19, 2022, Sadlier et al

    https://onlinelibrary.wiley.com/doi/10.1111/all.15253 Letter, open access Cork study Serum was obtained from PASC patients (n = 20) at two time points (4–6 months following infection (T1) and 6–9 months following infection (T2)). All patients had been hospitalized for PCR-proven SARS-CoV-2...
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