alzheimers

Dana M. Cairns [1,2], Nicolas Rouleau [1,2], Rachael N. Parker [1], Katherine G. Walsh [3], Lee Gehrke [4] and David L. Kaplan [1,2]* 1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. 2. Allen Discovery Center, Tufts University, Medford, MA 02155, USA. 3...

This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for targets for T-Cell expansion. For Alzheimer's they found TCR's responding to two separate Epstein–Barr virus antigens in CSF...

Today, in ME headlines of the future: The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades Familiar themes: Almost feel like crying seeing those numbers and "woefully insufficient": I hope discussion of this makes an opening to make it known that the...

https://www.medpagetoday.com/neurology/alzheimersdisease/83410 mentions microglia inflammation. Cheap trial *only* cost $2 million.

https://www.alzheimers.org.uk/blog/late-new-type-dementia New type of dementia discovered

Thought this was relevant since @Jonathan Edwards has mentioned gait as a possible diagnostic tool in ME. Link: https://www.alzheimersanddementia.com/article/S1552-5260(19)35120-9/fulltext

interesting story - he had NPH normal pressure hydrocephalus I’d not heard of that before but apparently it does get mistaken for Alzheimer’s https://www.bbc.co.uk/news/world-us-canada-49375308

https://www.washingtonpost.com/business/economy/pfizer-had-clues-its-blockbuster-drug-could-prevent-alzheimers-why-didnt-it-tell-the-world/2019/06/04/9092e08a-7a61-11e9-8bb7-0fc796cf2ec0_story.html?utm_term=.1418de0736c6 Not ME/CFS, but provides an overview of the difficulty of new drug...

https://www.cnn.com/2019/04/27/health/video-game-alzheimers-scn-trnd/index.html

Had this review pointed out to me as being potentially of interest. Open access at https://academic.oup.com/femsre/article/39/4/567/2467761

Might increased serum NfL also be a potential biomarker for ME/CFS since it is for Alzheimer’s and other neurological disorders? https://www.nature.com/articles/s41591-018-0304-3

Neuroinflammation findings with Alzheimer's, strikes a familiar note for pwME regarding our own neurological symptoms. A CBC radio program aired on Quirks and Quarks on December 8, 2018, discusses the theory of amyloid-beta plaques in Alzheimer's, protecting the brain from infection...

Artificial intelligence predicts Alzheimer's years before diagnosis in small UCSF study. Study: A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain https://pubs.rsna.org/doi/10.1148/radiol.2018180958 Press Release: AI Predicts Alzheimers Years...

http://www.bbc.com/future/story/20181022-there-is-mounting-evidence-that-herpes-leads-to-alzheimers?ns_campaign=bbc_radio_4&ns_linkname=radio_and_music&ns_source=facebook&ns_mchannel=social

Scientific American article on the search for an Alzheimer's biomarker, and how both the FDA and Bill Gates have made finding an inexpensive blood test for Alzheimer's a priority. We Need New Biomarkers for Alzheimer's Disease They're essential to coming up with better treatments, and a new...

UDCA (Ursodeoxycholic Acid) is currently being used for Cholestasis and PBC. Posted here for its improval on Mitochondrial function. Link : https://www.sciencedirect.com/science/article/pii/S0022283618309872

Thought this was interesting, and that I could remember that lipids were of interest to us? https://www.alz.org/aaic/releases_2018/AAIC18-Tues-gut-liver-brain-axis.asp

https://www.alzheimersresearchuk.org/new-findings-link-activity-gut-liver-alzheimers-risk/ @mariovitali may be of interest

Abstract: Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging https://jamanetwork.com/journals/jamaneurology/article-abstract/2687472 Press release: Yale-developed test for Alzheimer’s disease directly measures synaptic...

Study: Five years before multiple sclerosis onset: Phenotyping the prodrome http://journals.sagepub.com/doi/full/10.1177/1352458518783662 Press Release: A constellation of symptoms presages first definitive signs of multiple sclerosis...