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Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease (2019) Preische, et al.

Discussion in 'Health News and Research unrelated to ME/CFS' started by leokitten, Jan 22, 2019.

  1. leokitten

    leokitten Senior Member (Voting Rights)

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    Might increased serum NfL also be a potential biomarker for ME/CFS since it is for Alzheimer’s and other neurological disorders?

    https://www.nature.com/articles/s41591-018-0304-3
     
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  2. leokitten

    leokitten Senior Member (Voting Rights)

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    One note to add to this interesting paper, is that while they've known that serum NfL isn't a very specific biomarker for Alzheimer's or other neurodegenerative diseases including inflammatory and autoimmune ones, it is a good marker of brain damage occurring due to the disease process. Would be very interesting to know if PwME have elevated serum NfL compared to controls.
     
  3. Hutan

    Hutan Moderator Staff Member

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    Good idea. I despair a bit when I hear that there aren't any good ideas about what to research in ME. To me it seems that there are so many things that could be done.

    e.g. Follow people as soon as they are diagnosed with glandular fever. Over the next few years, collect data on physical health, take blood samples and check for stuff*. See if there are any differences between those who get post viral fatigue/ME and those who don't.

    *Stuff:
    • this NfL for one. Wouldn't it be useful for hypothesis making to have a good indication that there is some brain damage happening - or not happening.
    • Eosinophils is another - my daughter was suspected of having appendicitis at ME onset so she had blood tests right at the beginning, unlike my son and I. She had a high level of eosinophils. "Eosinophils help promote inflammation, which plays a beneficial role in isolating and controlling a disease site. But sometimes inflammation may be greater than is necessary". So maybe eosinophil levels are an early indicator of post-viral consequences?
    • Other stuff
     
  4. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    FYI - Gorden Broderick did evaluate blood from one such study
    Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue (2012)

     
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