alzheimers

The Centre Director for UK Dementia Research Institute at King’s was first to deliver a lecture as part of the 2022/23 IoPPN Inaugural Lecture Series. lecture (32 mins) available at link...

Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...

https://www.psychologytoday.com/gb/blog/mental-mishaps/202209/will-covid-brain-fog-increase-risks-alzheimer-s-disease

Article: Science, Blots on a field ?, Charles Piller First para: "In August 2021, Matthew Schrag, a neuroscientist and physician at Vanderbilt University, got a call that would plunge him into a maelstrom of possible scientific misconduct. A colleague wanted to connect him with an attorney...

https://www.medpagetoday.com/meetingcoverage/aan/98099

New insights into the genetic etiology of Alzheimer’s disease and related dementias https://www.nature.com/articles/s41588-022-01024-z Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better...

Abstract As one of the leading causes of dementia, Alzheimer’s disease (AD) is a condition in which individuals experience progressive cognitive decline. Although it is known that beta-amyloid (Aβ) deposits and neurofibrillary tangles (NFT) of tau fibrils are hallmark characteristics of AD, the...

In conclusion, we show reduced mitochondrial respiration in skeletal muscle, a metabolic tissue that is critical for strength, movement, and metabolism particularly in aging, during the earliest stages of AD-related cognitive decline; and effects that appear to be affected by the commonly used...

https://www.nytimes.com/2021/05/28/opinion/alzheimer-treatment-FDA-aducanumab.html?action=click&module=Opinion&pgtype=Homepage They’ve spent billions on Alzheimer’s and sounds like they still have nothing. Worth reading even though it’s not about MECFS.

Abstract Much of human behaviour is motivated by the drive to experience pleasure. The capacity to envisage pleasurable outcomes and to engage in goal-directed behaviour to secure these outcomes depends upon the integrity of frontostriatal circuits in the brain. Anhedonia refers to the...

https://www.reuters.com/article/us-elililly-alzheimers/lilly-says-alzheimers-drug-slows-clinical-decline-in-mid-stage-trial-idUSKBN29G161 https://www.bloomberg.com/news/articles/2021-01-11/lilly-surges-as-experimental-alzheimer-s-drug-shows-promise

Abstract This is a significant finding not only on the Alzheimer's front. Previously, the exact role of the immune system in early-onset Alzheimer's was unclear. Early-onset Alzheimer's is one of the diseases also showing overlaps with CFS/ME. This is one of the reasons why a differential...

https://www.nature.com/articles/d41586-020-03084-9

Dana M. Cairns [1,2], Nicolas Rouleau [1,2], Rachael N. Parker [1], Katherine G. Walsh [3], Lee Gehrke [4] and David L. Kaplan [1,2]* 1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. 2. Allen Discovery Center, Tufts University, Medford, MA 02155, USA. 3...

This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for targets for T-Cell expansion. For Alzheimer's they found TCR's responding to two separate Epstein–Barr virus antigens in CSF...

Today, in ME headlines of the future: The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades Familiar themes: Almost feel like crying seeing those numbers and "woefully insufficient": I hope discussion of this makes an opening to make it known that the...

https://www.medpagetoday.com/neurology/alzheimersdisease/83410 mentions microglia inflammation. Cheap trial *only* cost $2 million.

https://www.alzheimers.org.uk/blog/late-new-type-dementia New type of dementia discovered

Thought this was relevant since @Jonathan Edwards has mentioned gait as a possible diagnostic tool in ME. Link: https://www.alzheimersanddementia.com/article/S1552-5260(19)35120-9/fulltext