Similar to doing an MOT on a car, scientists believe they can run a blood test to check how fast a person's internal organs are ageing, and even predict which ones might soon fail.
The Stanford University team say they can monitor 11 major body parts, including the heart, brain and lungs.
They...
Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awad303/7308687
Brain, awad303, https://doi.org/10.1093/brain/awad303
Published: 18 October 2023
Abstract
Alzheimer’s disease is a...
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
Abstract
COVID-19 has represented an issue for global health since its outbreak in March 2020. It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics
Petersen, Mark A.; Ryu, Jae Kyu; Akassoglou, Katerina
The blood coagulation protein fibrinogen is deposited in the brain in a wide range of neurological diseases and traumatic injuries with blood–brain barrier (BBB)...
The Centre Director for UK Dementia Research Institute at King’s was first to deliver a lecture as part of the 2022/23 IoPPN Inaugural Lecture Series.
lecture (32 mins) available at link...
Preprint
See post 5 for published version
Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals
Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...
Article: Science, Blots on a field ?, Charles Piller
First para:
"In August 2021, Matthew Schrag, a neuroscientist and physician at Vanderbilt University, got a call that would plunge him into a maelstrom of possible scientific misconduct. A colleague wanted to connect him with an attorney...
New insights into the genetic etiology of Alzheimer’s disease and related dementias
https://www.nature.com/articles/s41588-022-01024-z
Abstract
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better...
Abstract
As one of the leading causes of dementia, Alzheimer’s disease (AD) is a condition in which individuals experience progressive cognitive decline. Although it is known that beta-amyloid (Aβ) deposits and neurofibrillary tangles (NFT) of tau fibrils are hallmark characteristics of AD, the...
In conclusion, we show reduced mitochondrial respiration in skeletal muscle, a metabolic tissue that is critical for strength, movement, and metabolism particularly in aging, during the earliest stages of AD-related cognitive decline; and effects that appear to be affected by the commonly used...
https://www.nytimes.com/2021/05/28/opinion/alzheimer-treatment-FDA-aducanumab.html?action=click&module=Opinion&pgtype=Homepage
They’ve spent billions on Alzheimer’s and sounds like they still have nothing. Worth reading even though it’s not about MECFS.
Abstract
Much of human behaviour is motivated by the drive to experience pleasure. The capacity to envisage pleasurable outcomes and to engage in goal-directed behaviour to secure these outcomes depends upon the integrity of frontostriatal circuits in the brain. Anhedonia refers to the...
Abstract
This is a significant finding not only on the Alzheimer's front. Previously, the exact role of the immune system in early-onset Alzheimer's was unclear. Early-onset Alzheimer's is one of the diseases also showing overlaps with CFS/ME. This is one of the reasons why a differential...
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