treatment

Hi, My question is has anybody tried fludrocortisone and has it made any difference? My M. E. is very severe I am bedbound does anybody know whether this would assist in enabling me to sit up in bed? I realise that you have to increase salt intake and wear compression stockings but I just...

This discussion has been split from the 2019 NIH conference thread I don't understand that. Orthostatic intolerance is the inability to tolerate standing up. By definition you know you have that if you have it. Maybe Dr Bateman is referring to haemodynamic changes that might be thought to...

hi I have a very low dose of Lyrica aka Pregabalin for neuropathic pain which I get in hands and feet most noticeably at night. I had a bad experience with it when I first started taking it because I’m one of those who are knocked out by medications. I’ve stopped taking amitryptiline or...

I haven't looked at this, but it sounds interesting and relevant. It is accepted by the CBT-GET promoters that there are biological changes in patients with ME. A key part of their argument has always been that psychotherapy can bring about or reverse biological changes. Here is a study that...

https://johnthejack.com/2019/03/16/toxic-numbers/

Paywalled at https://www.cambridge.org/core/journals/behavioural-and-cognitive-psychotherapy/article/implementation-of-stepped-care-for-patients-with-chronic-fatigue-syndrome-in-communitybased-mental-health-care-outcomes-at-posttreatment-and-longterm-followup/842DB10C681E7D7A8725BE0DB8848B07

Source: Clinical Therapeutics Preprint Date: March 6, 2019 URL: https://www.sciencedirect.com/science/article/abs/pii/S0149291819300475 Treatment avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A split-gender pharmacogenomic study of gene-expression modules...

Drink cocoa for chronic fatigue. Not a recommendation. Not looked at details. https://jnnp.bmj.com/content/early/2019/01/31/jnnp-2018-319496

Source: Prescriber February 2019, pp 29-33 Date: February 20, 2019 URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/psb.1741 https://onlinelibrary.wiley.com/doi/epdf/10.1002/psb.1741 Prescribing for patients with chronic fatigue syndrome...

https://www.madinamerica.com/2019/02/new-book-deconstructs-ideology-of-cognitive-therapy/

I convinced my GP to let me try Mestinon about 18 months ago, but never got as far as actually trying it until now. I have been holding off because I didn't want to muddle the results by starting it too close to my last rtx dose or while I was starting out on LDN. While LDN is extremely...

Our local NHS provider and lead commissioner have stated they will be going through a 'Benchmarking' exercise... So I thought I would do a little digging taking into account the current parlous state of NHS Services for ME and CFS... any thoughts would be welcome ...

I’ve been reading this 2013 study by Friedberg et al. Chronic fatigue self-management in primary care: a randomized trial. This isn’t a study of ME/CFS, but the paper claims that 39% of the 111 randomized participants did meet diagnostic criteria for CFS (Fukuda-criteria). I don’t think the...

The online guidance to doctors that I am reviewing has the following section about the use of antidepressants as treatments for ME/CFS: 1. The use of antidepressants in CFS has not shown a significant benefit:2 · There can be similarities in symptoms between CFS, depression, and...

Open access at https://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-018-0022-z

Initiating Care of a Patient with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) This paper introduces the primary care physician to the unique and challenging aspects of initially diagnosing and managing a complex condition for which there are a plethora of symptoms, few physical...

Open access at https://onlinelibrary.wiley.com/doi/full/10.1111/hex.12857

Free full text: http://iacfsme.org/PDFS/Reporting-of-Harms-Associated-with-GET-and-CBT-in.aspx

Rituximab Serum Concentrations and Anti- Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome Rekeland, Fluge, Mella et al (only the abstract is available for now) Findings There were no significant differences in mean serum rituximab...

Wall Street Wants the Best Patents, Not the Best Drugs - Curing diseases like Hepatitis C just doesn’t pay. By Joe Nocera - Bloomberg Opinion I agree!