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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the pandemic Coronavirus Disease 2019 (COVID-19) and now many face the burden of prolonged symptoms—long-lasting COVID-19 symptoms or “long-COVID”. Long-COVID is thought to be linked to immune dysregulation due to harmful...

Abstract Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder...

Not sure which forum to post this to but it looks interesting. https://www.hindawi.com/journals/prm/2021/6627864/ Research Article | Open Access Volume 2021 |Article ID 6627864 | https://doi.org/10.1155/2021/6627864 Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic...

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study Abstract Background: The purpose of this study was to follow-up an Australian cohort of adolescents newly-diagnosed with ME/CFS at a...

Does the Lightning Process Training Programme Reduce Chronic Fatigue in Adolescent and Young Adult Cancer Survivors? A Mixed-Methods Pilot Study Abstract Background: We report on a pilot intervention study exploring the efficacy of the Lightning Process® training programme for reducing chronic...

Full title: Sex differences in the trajectories to diagnosis of patients presenting with common somatic symptoms in primary care: an observational cohort study Highlights • Sex differences exist in diagnostic trajectories of patients with somatic symptoms. • Men with somatic symptoms receive...

Full title: Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol Abstract Background This study sought to establish the long-term effects of Covid-19 following hospitalisation. Methods...

Abstract The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other...

Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study Abstract Background: Internet-based cognitive behavior therapy (I-CBT) for adolescents with chronic...

Abstract Chronic fatigue complaints are frequently reported in the general population and fatigue ranks among the most commonly reported symptoms in chronic disease. In contrast to its high prevalence and impact on quality of life, relatively little is understood about the etiology of chronic...

In mice. Abstract Epstein-Barr virus (EBV) infection is associated with rheumatoid arthritis (RA) in adults, though the nature of the relationship remains unknown. Herein, we have examined the contribution of viral infection to the severity of arthritis in mice. We have provided the first...

Abstract Background Some Coronavirus disease 2019 (COVID-19) patients who have recovered from their acute infection after experiencing only mild symptoms continue to exhibit persistent exertional limitation that is often unexplained by conventional investigative studies. Research question What...

Abstract Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was to evaluate a possible diagnostic...

Abstract Background Persistent symptoms including breathlessness, fatigue and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this ‘Long COVID’ syndrome remain unknown. However, autopsy studies have highlighted...

I have no idea what this is like. Free full text https://journals.sagepub.com/doi/full/10.1177/23743735211034962 Successful Psychological Strategies of Experienced Chronic Fatigue Patients: A Qualitative Study Katherine H Hall, BSc(Med), BA, MBBS, PhD, FRNZCGP, Claire Amos, BSc(Hons)...

Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness accompanied by fatigue unsolved by rest. However, ME/CFS is a poorly understood illness that lacks a universally accepted pathophysiology and treatment. A lack of CFS-related...

Abstract Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from a variety of physical and neurological complaints indicating the central nervous system plays a role in ME/CFS pathophysiology. Diffusion tensor imaging (DTI) has been used to study microstructural changes...

Highlights The magnitude of early CD4+ T cell responses correlates with severity of COVID-19 Prior lung disease correlates with higher SARS-CoV-2-specific CD8+ T cell responses PASC is associated with a decline in N-specific interferon-γ-producing CD8+ T cells Neutralizing capacity correlates...

Abstract Chronic fatigue and Immune Dysfunction Syndrome (CFIDS) is a heterogeneous disease that may be promoted by various environmental stressors, including viral infection, toxin uptake, and ionizing radiation exposure. Previous studies have identified mitochondrial dysfunction in CFIDS...

Abstract Introduction: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between Human Herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis...