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Objective: As the number of recovering COVID-19 patients increases worldwide, the persistence of symptoms and signs through the post-acute phase indicates an urgent need for prolonged follow-up care. To explore existing data about post-acute COVID-19 syndrome, this meta-analysis assesses the...

Daroische R, Hemminghyth MS, Eilertsen TH, Breitve MH, Chwiszczuk LJ. Cognitive Impairment After COVID-19. A Review on Objective Test Data. Front Neurol. 2021 Jul 29;12:699582. doi: 10.3389/fneur.2021.699582. PMID: 34393978; PMCID: PMC8357992. https://pubmed.ncbi.nlm.nih.gov/34393978/...

Abstract Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive. Emerging evidence supports an association between mitochondrial dysfunction and AS. In our...

Abstract Background Dyspnea and exercise intolerance are commonly reported post-acute sequelae of SARS-CoV-2 infection (PASC), but routine diagnostic testing is often normal. Cardiopulmonary exercise testing (CPET) offers comprehensive assessment of dyspnea to characterize pulmonary PASC...

Highlights • ME/CFS, a clinical entity of unknown etiology characterized by PEM, is easily diagnosed when following available guidelines. • Patients with ME/CFS typically have small hearts, low stroke volume, and low total blood volume, and some have OI. • More studies are needed to understand...

Abstract Objectives: This study aimed to explore the experience of cognitive behavioural therapy (CBT) aimed at better management of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), rather than increasing activity. Design: This was a qualitative study using grounded theory...

Abstract Background The tryptophan–kynurenine–nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in central nervous system (CNS)...

frontiers in Systems Neuroscience Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Result in Sustained Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Pereira, Bateman et al Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex...

Predictors of Nonseroconversion after SARS-CoV-2 Infection https://wwwnc.cdc.gov/eid/article/27/9/21-1042_article ____________________ CDC study finds that 36% of COVID patients never make antibodies This has implications for prevalence studies of long covid that assume a lack of...

Abstract Functional autoantibodies directed to the M2 muscarinic acetylcholine receptor (M2R) could affect the heart rate directly by altering cardiac M2R activity and/or indirectly by changing vagal-mediated cardiac M2R activity. We measured M2R autoantibody activity in sera from 10 subjects...

Abstract Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to eight months after laboratory confirmed COVID-19 disease compared to a control group of SARS-CoV-2 negative patients. We followed a cohort of 8786...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1371754/ Abstract In order to examine the prevalence of patients with symptoms fulfilling the criteria for the chronic fatigue syndrome an extensive survey was carried out of general practitioners on 10 local government lists in two health boards...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1371214/ Abstract A case definition for post-viral fatigue syndrome is proposed within which various subgroups of patients exist. Any one treatment may not apply to all the subgroups. In particular, patients' experiences do not show that avoidance of...

Highlights • Long Covid is a patient-defined illness which gained legitimacy in online communities. • We analysed long Covid narratives using socio-narratology. • Narrators used literary devices to make sense of illness and persuade their audiences. • A unique feature of many narratives was...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global...

Not new but thought it might be of interest. (the Peer Review report is also available , one of the reviewers is Chew-Graham) Abstract Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) can cause profound and prolonged illness and disability, and poses significant problems...

Highlights • CBT is a promising treatment for patients with FND. • Remote delivery of CBT can potentially increase access to care for patients with FND. • Remote CBT can be integrated into clinical practice using a stepwise approach. • Remote CBT can be integrated into practice using...

BACKGROUND Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific biomarkers. Despite patient heterogeneity linked to...

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Scheibenbogen et al Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an...

Abstract PRINCE Secondary was a randomised trial to test the efficacy and cost-effectiveness of therapist-delivered, transdiagnostic cognitive behavioural therapy (TDT-CBT) for patients with persistent physical symptoms (PPS) (Chalder et al., 2021). In total, 324 PPS patients were randomised to...