genetics

Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Melanie Perez1, 2, Rajeev Jaundoo1, Kelly Hilton1, 2, Ana Del Alamo1, 2, Kristina Gemayel1, Nancy G. Klimas1, 2, Travis J. Craddock1, 3* and Lubov Nathanson1, 2* Provisionally accepted; full text...

Access via Twitter. Very interesting research re genetic memory and re- engagement of fetal development genes. Of specific interest for cancer and aging, but by pressing methylation on / off switches , perhaps has relevance for ME too...

Struggling at the moment to find more details about this, if/when I do I'll edit them in here. From https://cureme.lshtm.ac.uk/researchers/our-collaborative-researchers/ ETA: Added detail from the CureME collaborators page.

Source: Clinical Therapeutics Preprint Date: March 6, 2019 URL: https://www.sciencedirect.com/science/article/abs/pii/S0149291819300475 Treatment avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A split-gender pharmacogenomic study of gene-expression modules...

Provisionally accepted https://www.frontiersin.org/articles/10.3389/fped.2019.00059/full full paper here: http://sci-hub.tw/https://www.frontiersin.org/articles/10.3389/fped.2019.00059/full I haven't read it all but not sure if I've posted it in the correct forum?: "EBV reactivation is a...

https://www.mirror.co.uk/news/uk-news/veterans-debilitating-gulf-war-syndrome-13911872

I just wanted to highlight a paper that came out today in Nature Genetics: Lakhani et al. (“Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes”). In this study, they used very large health insurance claims data to compare whether...

https://www.sciencedirect.com/science/article/pii/S1094695018302440

https://www.nature.com/articles/d41586-018-07750-x

Open access at https://www.dovepress.com/a-predictive-algorithm-to-identify-genes-that-discriminate-individuals-peer-reviewed-fulltext-article-JPR

Having read this article on Allergies, The scourge of modern living I found it fitted in with my line of thinking about ME/CFS. I hope I don’t lose the excellent value of the article by summarising it as follows; Food allergies are on the increase in the modern world. Why might something as...

https://www.tandfonline.com/doi/full/10.1080/15592294.2018.1549769?scroll=top&needAccess=true Abstract published. Article behind a paywall. Research financed by Solve ME/cfs.

Paywalled at https://www.sciencedirect.com/science/article/pii/S0889159118307967?via%3Dihub

Nathaniel Comfort questions a psychologist’s troubling claims about genes and behaviour. 25 September 2018 https://www.nature.com/articles/d41586-018-06784-5 (not exactly related to this piece but I am reminded of Crawley saying that CFS is 'more genetically heritable in children')

https://rarediseases.info.nih.gov/diseases/3335/lysinuric-protein-intolerance https://ghr.nlm.nih.gov/condition/lysinuric-protein-intolerance I just wanted to start a discussion on this inborn error of metabolism.

Mentioned on another thread. ME/CFS Genes Study " We are currently recruiting ME/CFS patients AND Healthy Controls for this completely web based study to create a one of a kind genetic database for individuals with ME/CFS. Participation for this study requires you to have a computer with...

Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing Dr Unutmaz is one of the principal investigator of this paper. http://www.jimmunol.org/content/early/2018/07/18/jimmunol.1701616?papetoc Abstract: Abstract Developing precise and efficient gene editing approaches...

Study: http://n.neurology.org/content/early/2018/07/03/WNL.0000000000005906 Summary: https://www.nationalmssociety.org/About-the-Society/News/Study-Finds-Exposure-to-Organic-Solvents-Smoking The genes that have been shown to affect MS susceptibility include HLA genes. Thought the HLA link...

https://www.ucsf.edu/news/2018/07/411031/crispr-toolkit-unlocks-new-ways-fight-disease

https://www.nature.com/collections/zbpsndwbnq/