Mechanistic Insights into the Pathophysiology of CFS/ME: Examining Nrf2 Antioxidant Gene Expression & its Role in Combating Oxidative Stress, ongoing

Andy · Mar 23, 2019

Struggling at the moment to find more details about this, if/when I do I'll edit them in here.

From https://cureme.lshtm.ac.uk/researchers/our-collaborative-researchers/

Professor Faisel Khan is a Professor of Cardiovascular Medicine at the University of Dundee. His study, “Mechanistic Insights into the Pathophysiology of CFS/ME: A Study Examining Nrf2 Antioxidant Gene Expression and its Role in Combatting Oxidative Stress”, examines an extremely important regulatory protein in the body called Nrf2, which is believed to be an activator of the body’s natural antioxidant defence mechanisms. It seeks to provide evidence of changes in Nrf2 production in people with ME.
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ETA: Added detail from the CureME collaborators page.

Amw66 · Mar 23, 2019

Andy said: ↑

Struggling at the moment to find more details about this, if/when I do I'll edit them in here.

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Dundee was where muscle research for children with "CFS" was done . Tymes promoted it, think it was funded by ME Research or Invest .

Dundee has done a bit of oaedupaedi research in conjunction with TT.
http://www.meresearch.org.uk/our-research/completed-studies/impact-in-childhood/

Perhaps moving into adults?

Eta link. Will try and find muscle study

Andy · Mar 23, 2019

This is their previous work on the same subject.

Their main finding, however, has been that people with ME/CFS have high levels of reactive oxygen molecules, which can harm blood vessels and muscles. These molecules are formed in the body during biological processes that use oxygen, such as exercise. In healthy people they are counter-balanced by antioxidants that detoxify the oxygen molecules to prevent damage, but sometimes an imbalance can lead to increased ‘oxidative stress’ and an increased risk of cardiovascular disease.

It is important to discover the origin of these molecules, so that ways of counteracting oxidative stress-related cardiovascular damage can be developed. For this reason, the research team in Dundee has received funding from ME Research UK to investigate the role of ‘nuclear factor erythroid-derived 2’ (Nrf2). This is an extremely important regulatory protein in the body, and is now believed to be a master activator of the body’s natural defence against oxidative stress. When reactive oxygen species are generated, Nrf2 is activated, stimulating the body’s antioxidant pathways and thereby providing a buffer against oxidative stress.
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http://www.meresearch.org.uk/our-research/ongoing-studies/combat-oxidative-stress/

mariovitali · Mar 23, 2019

It sounds like very interesting work.

lansbergen · Mar 23, 2019

Their main finding, however, has been that people with ME/CFS have high levels of reactive oxygen molecules, which can harm blood vessels and muscles.

I am pretty sure in my case they are skyhigh during flares.

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