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genetics

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  1. Simon M
    Thread

    "Why do we need a genetic study like DecodeME?" Blog in British Science Week.

    I hope the Mods won't mind me creating a thread for this blog, which looks at why genetic studies are so important. Posted for British Science...
    Thread by: Simon M, Mar 14, 2022, 0 replies, in forum: ME/CFS research news
  2. Sly Saint
    Thread

    Podcast: Mitochondrial Dysfunction and Autism with Dr. Richard G. Boles

    not listened to it so no idea of content. In this episode I welcome on Dr. Richard Boles. Dr. Richard G. Boles is a medical geneticist and a...
    Thread by: Sly Saint, Dec 7, 2021, 1 replies, in forum: Other health news and research
  3. Andy
    Thread

    Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders, 2021, Eijsbout

    Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the...
    Thread by: Andy, Nov 6, 2021, 15 replies, in forum: Other health news and research
  4. Andy
    Thread

    BBC Article Oct 2021: Gene silencing medicine transforms crippling pain

    Quote: An innovative type of medicine - called gene silencing - is set to be used on the NHS for people who live in crippling pain. The drug...
    Thread by: Andy, Oct 21, 2021, 1 replies, in forum: Other health news and research
  5. Kitty
    Thread

    UK genetic study on autism

    As people may have heard in the news, a new study launched yesterday called Spectrum10k. I thought I'd post it here in case any of our autistic...
    Thread by: Kitty, Aug 25, 2021, 28 replies, in forum: Other health news and research
  6. Andy
    Thread

    Fine mapping of the major histocompatibility complex (MHC) in (ME/CFS) suggests involvement of both HLA class I and class II loci, 2021, Hajdarevic

    Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests...
    Thread by: Andy, Aug 18, 2021, 14 replies, in forum: ME/CFS research
  7. Andy
    Thread

    Pediatric Paroxysmal Exercise-Induced Neurological Symptoms: Clinical Spectrum and Diagnostic Algorithm, 2021, Dante et al

    Paroxysmal exercise-induced neurological symptoms (PENS) encompass a wide spectrum of clinical phenomena commonly presenting during childhood and...
    Thread by: Andy, Jun 22, 2021, 1 replies, in forum: Other health news and research
  8. Sly Saint
    Thread

    Identification of differential genetic profiles in severe forms of fibromyalgia and CFS/ME, 2008, Garcia-Fructuoso et al

    Identification of differential genetic profiles in severe forms of fibromyalgia and chronic fatigue syndrome/myalgic encephalomyelitis: A...
    Thread by: Sly Saint, May 13, 2021, 0 replies, in forum: ME/CFS research
  9. voner
    Thread

    Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain, Md Shafiqur Rahman, et al, 2020

    Abstract Background and Objectives Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly...
    Thread by: voner, May 1, 2021, 14 replies, in forum: Other health news and research
  10. Andy
    Thread

    Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Sato et al

    Highlights • ME/CFS is characterized by skewed B cell receptor gene usage. • Upregulation of specific IGHV genes correlated to infection-related...
    Thread by: Andy, Apr 2, 2021, 26 replies, in forum: ME/CFS research
  11. Sly Saint
    Thread

    Genetic association study of psychotic experiences in UK Biobank: Psychotic experiences in UK Biobank, 2019, Hotopf et al

    " Abstract Importance Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5%-10% of the general population,...
    Thread by: Sly Saint, Mar 9, 2021, 1 replies, in forum: Other health news and research
  12. mat
    Thread

    Public Attenuated CSF‐1R signalling drives cerebrovascular pathology

    Abstract Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to...
    Thread by: mat, Jan 5, 2021, 0 replies, in forum: Other health news and research
  13. John Mac
    Thread

    Re-analysis of genetic risks for Chronic Fatigue Syndrome from 23andMe data finds few remain, Bedford et al, 2020 [Preprint]

    Abstract It is tempting to mine the abundance of DNA data that is now available from direct-to-consumer genetic tests, but this approach has its...
    Thread by: John Mac, Oct 30, 2020, 9 replies, in forum: ME/CFS research
  14. John Mac
    Thread

    Genetic Risk Factors of ME/CFS: A Critical Review. Joshua J Dibble, Simon J McGrath, Chris P Ponting. 2020

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex multisystem illness that lacks effective therapy and a...
    Thread by: John Mac, Aug 3, 2020, 9 replies, in forum: ME/CFS research
  15. ME/CFS Skeptic
    Thread

    Evidence for a genetic component in ME/CFS - discussion thread

    I'm looking for evidence for a genetic component in ME/CFS and a discussion of the quality of evidence for each the studies. Here are some I...
    Thread by: ME/CFS Skeptic, Jul 30, 2020, 22 replies, in forum: ME/CFS research
  16. Andy
    Thread

    Case report: Association of small-fiber polyneuropathy with three previously unassociated rare missense SCN9A variants, 2020, Kelly and Oaklander

    Background: Small fiber polyneuropathy (SFN) involves ectopic firing and degeneration of small-diameter, somatic/autonomic peripheral axons....
    Thread by: Andy, Jul 29, 2020, 0 replies, in forum: ME/CFS research
  17. Cheshire
    Thread

    A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia (2020) van Tilburg et al.

    Alterations in cellular energy metabolism have been implicated in chronic pain suggesting a role for mitochondrial DNA (mtDNA). Previous studies...
    Thread by: Cheshire, Jul 18, 2020, 5 replies, in forum: 'Conditions related to ME/CFS' news and research
  18. NelliePledge
    Thread

    DecodeME - UK ME/CFS DNA study underway

    Moderator note: Please note: at this point only people from the UK will be eligible to participate in the study. However people from...
    Thread by: NelliePledge, Jun 23, 2020, 684 replies, in forum: ME/CFS research news
  19. Kalliope
    Thread

    Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on ME/CFS, 2020, Sepulveda et al

    Provisionally accepted opinion article in frontiers in Pediatrics - Paediatric Neurology Review of the Quality Control Checks Performed by...
    Thread by: Kalliope, May 8, 2020, 3 replies, in forum: Research methodology news and research
  20. Ron
    Thread

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4...
    Thread by: Ron, Apr 12, 2020, 10 replies, in forum: ME/CFS research
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