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Current: Genome-wide association study in (CFS/ME) to uncover the genetic susceptibility and identify biological pathways involved

Discussion in 'BioMedical ME/CFS Research' started by Andy, Mar 26, 2020 at 8:41 PM.

  1. Andy

    Andy Committee Member & Outreach

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    I searched but couldn't find this here, which is surprising. I've also Googled and can't find details of this elsewhere.
    https://www.ukbiobank.ac.uk/2019/12...ty-and-identify-biological-pathways-involved/
     
  2. lunarainbows

    lunarainbows Senior Member (Voting Rights)

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    @Andy will the announcement of whether or not UK GWAS was awarded the funding, be delayed now, because of the coronavirus?
     
  3. Andy

    Andy Committee Member & Outreach

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    So far as we know, no, but it wouldn't be surprising if it was - at the moment we are still waiting to hear one way or the other from the funders.
     
  4. Cinders66

    Cinders66 Senior Member (Voting Rights)

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    So this is another gwas study ? Is it funded ?
     
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  5. Kalliope

    Kalliope Senior Member (Voting Rights)

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    I wonder if this is the same study that was talked about at the CFS/ME Research Conference in Oslo back in Nov. 2019. Thread and post with slides here.

    ETA: Also a lecture from 2018. Thread with summary in English here.
     
  6. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Prof. Benedicte A. Lie is also a co-author of the recent Nature study "Human Leukocyte Antigen alleles associated with ME/CFS" from among others Fluge and Mella.
     
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  7. Andy

    Andy Committee Member & Outreach

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    Great, thanks Kalliope.
    Presentation doesn't mention the UK Biobank at all though. Those numbers, as far as I understand it, while impressive currently for an ME/CFS study, aren't high enough to have high confidence in the results. Having said that, from the slides I think they are focusing more tightly on particular areas of the genome, so that might make a difference? I'm more talking out loud, rather than asking anybody in particular.
     
  8. Chris Ponting

    Chris Ponting Established Member (Voting Rights)

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    Small study, but great to see a genetic signal. This needs replication and more samples, but at the moment this does point towards an adaptive immune contribution to ME. Encouraging.

    Mod note: Post copied to Human Leukocyte Antigen alleles study
    Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Fluge, Mella et al 2020
     
    Last edited by a moderator: Mar 28, 2020 at 12:51 AM
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