Discussion in 'Fibromyalgia and Connective Tissue Disorders' started by Andy, Dec 15, 2018.
Open access at https://www.dovepress.com/a-predict...ndividuals-peer-reviewed-fulltext-article-JPR
cc : @ScottTriGuy @JaimeS
Making a correction / addition from other part of the text :
and to be fair :
With such small amounts of data I'm not sure that any results will be meaningful. They use a cross validation techniques which is better than some we have seen.
This is true and it’s been discussed in the text.
I think that we must see the bigger picture since we have from previous research work from Hanson, Naviaux , Flugge / Mella :
-Impaired Bile Acids metabolism
-Impaired phospholipid metabolism
-Metabolites suggesting hepatotoxicity
-Impaired Vitamin E metabolism which may be attributed to impaired hepatic function
All these may suggest that we must pay closer attention to the Liver
This is vaguely interesting - the question is are these directly involved in fatigue signalling mechanisms or are they merely a nonspecific side effect of different activity patterns of people who happen to be suffering from severe fatigue.
For the record, the techniques that i use agree with other mentions in the paper for Protein Kinase B (PKB) and Nf-kΒ pathway.
In any case, i am really happy that these techniques are being put into use more and more. Used correctly, they may prove to be very useful in generating interesting hypotheses for ME/CFS.
I agree, but virtually impossible to get anyone to consider this. I' ve given up with my GP and no private providers do any other investigative processes anywhere near us. I am hoping that this gets further study.
Just wanted also to add, as shown on the figure 4C of the paper below, although not a strong signal, Tyrosine is being mentioned :
I would like to confirm that based on the techniques i use, Tyrosine metabolism is an important element of ME/CFS (hypothesis). This was also discussed in the following post :
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