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A predictive algorithm to identify genes that discriminate individuals with fibromyalgia syndrome diagnosis from healthy controls, 2018, Saliqan et al

Discussion in 'Fibromyalgia and Connective Tissue Disorders' started by Andy, Dec 15, 2018.

  1. Andy

    Andy Committee Member & Outreach

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    Open access at https://www.dovepress.com/a-predict...ndividuals-peer-reviewed-fulltext-article-JPR
     
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  2. mariovitali

    mariovitali Senior Member (Voting Rights)

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    @Andy

    cc : @ScottTriGuy @JaimeS


    Making a correction / addition from other part of the text :


    and to be fair :


     
    Last edited: Dec 15, 2018
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  3. Adrian

    Adrian Administrator Staff Member

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    With such small amounts of data I'm not sure that any results will be meaningful. They use a cross validation techniques which is better than some we have seen.
     
  4. mariovitali

    mariovitali Senior Member (Voting Rights)

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    This is true and it’s been discussed in the text.

    I think that we must see the bigger picture since we have from previous research work from Hanson, Naviaux , Flugge / Mella :

    -Impaired Bile Acids metabolism
    -Impaired phospholipid metabolism
    -Metabolites suggesting hepatotoxicity
    -Impaired Vitamin E metabolism which may be attributed to impaired hepatic function

    All these may suggest that we must pay closer attention to the Liver
     
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  5. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    This is vaguely interesting - the question is are these directly involved in fatigue signalling mechanisms or are they merely a nonspecific side effect of different activity patterns of people who happen to be suffering from severe fatigue.
     
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  6. mariovitali

    mariovitali Senior Member (Voting Rights)

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    Good question.

    For the record, the techniques that i use agree with other mentions in the paper for Protein Kinase B (PKB) and Nf-kΒ pathway.


    In any case, i am really happy that these techniques are being put into use more and more. Used correctly, they may prove to be very useful in generating interesting hypotheses for ME/CFS.
     
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  7. Amw66

    Amw66 Senior Member (Voting Rights)

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    I agree, but virtually impossible to get anyone to consider this. I' ve given up with my GP and no private providers do any other investigative processes anywhere near us. I am hoping that this gets further study.
     
  8. mariovitali

    mariovitali Senior Member (Voting Rights)

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