glutamate

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a...

The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08. From GeneCards: Here is a plot of this locus (LocusZoom link): Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559

B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism B cells are an essential component of humoral immunity, and B cell depletion therapies have clinically succeeded in eliminating cancerous B cells and treating autoimmune diseases. Here, we report an...

Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition The development and persistence of symptoms following SARS-CoV-2 infection, known as Post-COVID-19 Condition (PCC) or “long COVID,” represents a global health challenge...

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy Abstract Cytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID-19 syndrome share a symptom profile, including severe fatigue, cognitive dysfunction, exertional intolerance, sleep disturbances, hypervigilance, and the paradoxical state of being “wired but tired.” A...

A Glutamatergic Medial Prefrontal Cortex–Locus Coeruleus Circuit Drives Intestinal Dysmotility in Diarrhea-Predominant Irritable Bowel Syndrome Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic disorder of gut–brain interaction characterized by intestinal dysmotility...

Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model The International Space Station provides an opportunity to study the impact of spaceflight on gene expression and possible links to human health. Our study investigates global changes in messenger...

Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue [Line breaks added] Abstract A major consequence of the COVID-19 pandemic has been the emergence of post-COVID syndrome (PCS), and more specifically, post-COVID fatigue (pCF), with an estimated prevalence...

Evidence of Impaired Neuroimmune System in Post‐COVID Syndrome—A Whole Brain Magnetic Resonance Spectroscopy Study [Line breaks added] Abstract Chronic fatigue, mood disturbances, and cognitive deficits characterize the neurological post‐COVID syndrome (PCS). This study aimed to find out if...

Abstract Rare genetic factors have been shown to substantially contribute to mental illness, but so far, no precision treatments for mental disorders have been described. It was recently identified that rare variants in GRIN2A encoding the GluN2A subunit of the N-methyl-D-aspartate receptor...

Tulane University: "Tulane scientists uncover new pain-signaling switch" 'Researchers found that nerve cells communicate outside the cell with the enzyme vertebrate lonesome kinase (VLK), which can alter proteins in the space between neurons, affecting how those cells send signals. “This is...

Chronic CXCL10 alters neuronal properties in rat hippocampal culture Abstract The chemokine CXCL10 is expressed in the central nervous system (CNS) during neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and neuronal function has been shown to be altered by acute...

AMPA receptors in the synapse: Very little space and even less time Jelena Baranovic Glutamate is by far the most abundant neurotransmitter used by excitatory synapses in the vertebrate central nervous system. Once released into the synaptic cleft, it depolarises the postsynaptic membrane and...

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and...

Long term effect of COVID-19 on brain metabolism and connectivity Beatrice Bravi; Marco Paolini; Federica Colombo; Mariagrazia Palladini; Valentina Bettonagli; Mario Gennaro Mazza; Rebecca De Lorenzo; Patrizia Rovere-Querini; Francesco Benedetti; Sara Poletti AIMS After 3 years from the...

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis Sai Zhang; Fereshteh Jahanbani; Varuna Chander; Martin Kjellberg; Menghui Liu; Katherine Glass; David Iu; Faraz Ahmed; Han Li; Rajan Douglas Maynard; Tristan Chou...

New insights into how glutamate opens brain cell signaling channels eta: Journal reference: Mondal, A. K., et al. (2025). Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Nature. doi.org/10.1038/s41586-025-08770-0.

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption Chaganti, Joga R.; Talekar, Tanush K.; Brew, Bruce James BACKGROUND AND PURPOSE The glymphatic system, a waste clearance pathway, has been implicated in several...

Neurometabolic network NMetNet for functional neurological disorder in children and adolescents Lan; Foster; Charney; Grinsven; Breedlove; Kozlowska; Lin OBJECTIVES Functional neurological disorder (FND) in children and adolescents is a biopsychosocially-complex condition characterized by a...