I came across a reference to Comhaire on a blog I like (Follow ME in Denmark) which was discussing impaired pyruvate dehydrogenase (PDH) functioning in ME/CFS i.e. Fluge & Mella's 2016 study. The blog also refers to a study on those born with a genetic impairment of PDH (Patel et al: The spectrum of pyruvate dehydrogenase deficiency) and the study showing elevated lactate in ME/CFS (Natelson et al: Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome). Fluge & Mella proposed that "something/s in the blood" was impairing PDH functioning. So presumably you need to find and turn off the production of that something/s. Ron Davis, as well as Fluge & Mella (and others) are looking for that something/s. I'm grateful to those who wrote the above posts ie. pointing out the flaws in Comhaire's claims. Presumably until we know more about the causes of ME/CFS there will be suggested cures/treatments which simply do not help. We need to try to help Ron Davis, Fluge & Mella (and others), possibly by trying to get our Members of the European Parliament/Members of the Westminster Parliament/other parliament to fund this type of biological research. The UNREST film might help. Thanks again for the cautionary comments re Comhaire's suggested "treatment" and please think about how we might influence those who can fund research.