I get the impression that the current series of articles are mainly about promoting the book that has been written about Ron Davis and his efforts to try to find what is wrong with his son. All very understandable, it's normal to get as much publicity as possible when a new book is coming out.
As to new developments, all we can do is wait and see. When I first heard about the nanoneedle a few years ago, I got the impression that development was imminent, and got quite excited. I now understand better that these things take time and money, and that work has continued on designing a bigger piece of equipment that can do many tests at the same time. I think the latest I heard was that orders had been placed for these prototypes but delayed because of covid. We still don't know whether it will turn out to be a useful test for ME. There are many stages of research, and replication by others to go through first.
As to the rest of the developments, again, I think it's best to be patient and wait for peer reviewed publications and then replications by others, before getting too excited. New ideas and hypotheses take time to be tested, and inevitably many will turn out to be dead ends. That's the way with science that is exploring areas where so much is unknown. Davis and Phair have said themselves that the 'metabolic trap' idea is just one of many ideas to explore, and that they will need to design new techniques even to try to test it, let alone find out whether it has any relevance to ME.
I understand the wish of people working in this field who know how little hope we have to cling to, to want to give us hope. I trust that they are doing their best and working hard, but I also have learned to be realistic that not all hopeful looking avenues will lead anywhere.
There's a difficult balance to be struck between the desire to give hope, and the need to be realistic and not give false hope that can lead to crushing disappointment. Personally I would think it better to hold back any talk of breakthroughs until there is solid evidence to support it. And by that I mean peer reviewed publication and replication.