rct

https://www.sciencemag.org/news/2019/05/solution-psychology-s-reproducibility-problem-just-failed-its-first-test?

https://journals.sagepub.com/doi/abs/10.1177/1359105319847261?journalCode=hpqa#articleShareContainer

B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial https://annals.org/aim/article-abstract/2729813/b-lymphocyte-depletion-patients-myalgic-encephalomyelitis-chronic-fatigue-syndrome-randomized...

A longish read. I skimmed through. An interesting quote from near the end: The activists questioned the gold standard of medical intervention research – the randomised, controlled trial – and showed how a series of normative assessments are made in all medical research, for example how study...

Two papers published today on the same subject, first: COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time Background Discrepancies between pre-specified and reported outcomes are an important source of bias in trials. Despite legislation...

Saw Keith Geraghty share this on Twitter. Paywalled at https://www.bmj.com/content/356/bmj.j396

Real-world studies no substitute for RCTs in establishing efficacy January 19, 2019 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32840-X/fulltext?utm_campaign=lancet&utm_content=83224321&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292#.XEgvxfcH2L0.twitter...

Open access at https://onlinelibrary.wiley.com/doi/full/10.1002/capr.12141 Posting this as it has been highlighted in the comments of Spoonseeker's latest blog that the concept expressed in this review is to be used to 'lower the bar' that NICE uses to assess treatments by, and therefore "to...

I know Ben Goldacre hasn't exactly covered himself in glory in relation to PACE but he does nevertheless say some interesting things. At the beginning of this talk he presents an interesting proposal about how to get a cheap and easy randomised trial across general practice whenever there is...

https://www.nature.com/articles/d41586-018-06676-8

Acceptance and Commitment Therapy for MuScle Disease (ACTMuS): Protocol for a two-arm randomised controlled trial of a brief guided self-help ACT programme for improving quality of life in people with Muscle diseases Trudie Chalder et Al From above: "ACT is a newer type of cognitive...

There are a number of tools available for journals to use to help assess RCTs. I wondered if anyone here had 'tried them out' for PACE and/or any of the other 'RCT's by Crawley or Chalder? I've seen CASP mentioned...

Yoga, Depression, & Clinical Trial Critique 101 Posted August 12, 2018 by Hilda Bastian in Evidence, Health http://blogs.plos.org/absolutely-maybe/2018/08/12/yoga-depression-clinical-trial-critique-101/ Not specifically about ME, but I thought it might be of interest to some people who are...

"Much of the social and medical sciences depend on randomised control trials. But while this may be considered the foundational experimental method, a certain degree of bias inevitably arises in any trial; whether this is sample bias, selection bias, or measurement bias. This is important as the...

From 2015 but to be presented in a talk in July at the Society for Academic Primary Care conference: https://sapc.ac.uk/conference/2018 https://sapc.ac.uk/conference/2018/abstract/actib-trial-assessing-cognitive-behavioural-therapy-irritable-bowel one of the co-authors is Susan Windgassen...

Citation Picariello F, Moss-Morris R, Macdougall IC, et al Cognitive-behavioural therapy (CBT) for renal fatigue (BReF): a feasibility randomised-controlled trial of CBT for the management of fatigue in haemodialysis (HD) patients BMJ Open 2018;8:e020842. doi: 10.1136/bmjopen-2017-020842...

https://www.ncbi.nlm.nih.gov/pubmed/29212562