multiple sclerosis

https://jnnp.bmj.com/content/early/2022/03/08/jnnp-2021-328700 Abstract Objective To study whether exposure to childhood emotional, sexual or physical abuse is associated with subsequent multiple sclerosis (MS) development. Methods A nationwide, prospective cohort study based on participants...

Highlights The factors driving persistent microglial activation associating with multiple sclerosis progression are uncertain. Several metabolites of the kynurenine pathway can influence the function of brain innate immune cells. Decreased serum 3-hydroxykynurenine correlates with increased...

Main paper Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US...

Abstract The identification of intestinal dysbiosis in patients with neurological and psychiatric disorders has highlighted the importance of gut-brain communication and yet, the question regarding the identity of the components responsible for this cross talk remains open. We previously...

Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis https://www.sciencedirect.com/science/article/pii/S2213158221000310?via=ihub Highlights • We compared monoaminergic fibre tracts integrity in...

Harrison, A. M., das Nair, R., & Moss-Morris, R. (2016). Operationalising cognitive fatigability in multiple sclerosis: A Gordian knot that can be cut? Multiple Sclerosis Journal, 23(13), 1682–1696. doi:10.1177/1352458516681862 sci-hub.se/10.1177/1352458516681862 Abstract Background...

Abstract Some illnesses and diseases are not apparent to onlookers. Conditions like chronic fatigue syndrome, fibromyalgia, multiple sclerosis, postconcussive syndrome, endometriosis, and many psychiatric illnesses, for example, have symptoms that are not easily or at all measurable. Both...

Full Title: Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis Abstract The gut microbiota is a potential environmental factor that influences the development of multiple sclerosis (MS). We and...

Abstract In the present study we conduct a systematic review to evaluate the needs and experience of people with pediatric multiple sclerosis (MS) and their caregivers. The literature search was conducted across 10 academic databases, adhering to PRISMA-P guidelines. Quality appraisal was...

http://fortune.com/2018/06/21/tuberculosis-vaccine-reverse-juvenile-diabetes-study-shows/

Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies Paula M. Ellison, Stuart Goodall, Niamh Kennedy, Helen Dawes, Allan Clark, Valerie Pomeroy, Martin Duddy, Mark R. Baker & John M. Saxton...

https://www.nature.com/articles/s41582-021-00496-7

https://multiplesclerosisnewstoday.com/news-posts/2021/01/21/new-ms-study-by-kessler-foundation-researchers-will-assess-effects-of-tysabri-on-cognitive-fatigue-in-relapsing-remitting-multiple-sclerosis-patients/

Anthony Harrison, Reza Safari Tom Mercer, Federica Picariello, Marietta L van der Linden, Claire White, Rona Moss-Morris Sam Norton** Abstract Background: Fatigue is a common, debilitating symptom of multiple sclerosis (MS) without a current standardised treatment. Objective: The aim of...

https://onlinelibrary.wiley.com/doi/10.1002/acn3.51325 Interpretation NAC was well‐tolerated in progressive MS, although reduction in fatigue on NAC was similar to placebo. Antioxidant blood and MRS biomarkers were not significantly altered by NAC, which could be due to dose, route of...

Mod note: we have broadened the scope of this thread which was originally just about the possibility of having both MS and ME/CFS. Is anyone living with both MS and ME and is there any real reason (research based) to believe that you can’t have both? I might have both, the reason for my...

https://link.springer.com/article/10.1007/s10286-021-00790-w

Nature Communications: Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling - Yee Ming Khaw et al Abstract Environmental triggers have important functions in multiple sclerosis (MS) susceptibility...

Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with Multiple Sclerosis https://www.mdpi.com/1660-4601/18/1/17/htm Not very relevant to us but always interesting to see how similar studies are run in other diseases. I am not aware if PEM...

https://www.mdpi.com/1010-660X/56/12/726?type=check_update&version=2