multiple sclerosis

In summary, we report that MS patients are hallmarked by an accumulation of immune responses specifically directed against EBV EBNA381–452 and cross-reacting with CNS GlialCAM370–389–, CRYAB2–21–, MBP205–224–, and ANO2135–154–derived epitopes. Although, our findings provide additional insights...

Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis Martina Rubin; Paolo Preziosa; Monica Margoni; Alessandro Meani; Elisabetta Pagani; Gianluca Corazzolla; Loredana Storelli; Damiano Mistri; Massimo Filippi; Maria A Rocca...

Epstein–Barr virus as a potentiator of autoimmune diseases William H. Robinson, Shady Younis, …Tobias V. Lanz Show authors Nature Reviews Rheumatology (2024)Cite this article Metricsdetails Abstract The Epstein–Barr virus (EBV) is epidemiologically associated with development of autoimmune...

Chronic fatigue syndrome and multiple sclerosis have reduced craniospinal compliance and dilated pressurized bridging cortical veins https://www.sciencedirect.com/science/article/pii/S0306987723002396?via=ihub Abstract Chronic fatigue syndrome (CFS) and multiple sclerosis (MS) share...

"On June 19, 2024, the Multiple Sclerosis Community Advisory Board (MS CAB) met with the EBV-MS project research team for a pivotal consultation. The objective of this meeting was to ensure meaningful engagement and involvement of expert patients in the ongoing EBV-MS clinical trials...

In the multicenter observational study, conducted across 13 hospitals in Spain and Italy, Dr. Enric Monreal and his team found that elevated serum neurofilament light chain (sNfL) levels—a protein indicating nerve cell damage—at the onset of MS can predict both relapse-associated worsening (RAW)...

Highlights • The impact of cognitive impairment in MS increases with greater disease progression (i.e., mobility disability). • Cognitive rehabilitation effectively improves one specific domain of learning and memory (i.e., list-learning). • Combining cognitive rehabilitation and aerobic...

Frontal-striatal glucose metabolism and fatigue in patients with multiple sclerosis, long COVID, and COVID-19 recovered controls Rudroff, Thorsten This study compared brain glucose metabolism using FDG-PET in the caudate nucleus, putamen, globus pallidus, thalamus, and dorsolateral prefrontal...

Now published - see here ***** An HERV-W ENV transcription in atypical memory B cells linked to COVID-19 evolution and risk for long COVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X. Joanna Brunel; Julien Paganini; Melissa Galloux; Benjamin Charvet...

Psychosomatic nonsense strikes again:

Abstract Background Epstein-Barr virus (EBV) is a likely prerequisite for multiple sclerosis (MS) but the underlying mechanisms are unknown. We investigated antibody and T cell responses to EBV in persons with MS (pwMS), healthy EBV-seropositive controls (HC) and post-infectious mononucleosis...

Comments on energy conservation treatments for MS-related fatigue and a new proposal https://www.sciencedirect.com/science/article/abs/pii/S0022510X24001758 Highlights We propose that fatigue in MS involves a sensory component reflecting the state of the immune system. The predetermined...

https://kclpure.kcl.ac.uk/portal/en/publications/the-presence-of-attentional-and-interpretation-biases-in-patients Access to Document The presence of attentional and_DE GIER_Accepted2024_AAM Accepted author manuscript, 461 KB The presence of attentional and interpretation biases in patients...

The Guardian science podcast has released an episode today about Epstein Barr Virus entitled The virus that infects almost everyone, and its link to cancer and MS – podcast https://www.theguardian.com/science/series/science There is a brief mention of how EBV 'contributes to some cases of...

Abstract Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease, relatively little is known about the precise nature of the immune dysregulation underlying the development of the disease. Reasoning that the CSF from patients might be enriched for cells relevant in...

Reduced Oxygen Extraction Fraction in Deep Cerebral Veins Associated with Cognitive Impairment in Multiple Sclerosis Hasan Sawan; Chenyang Li; Sagar Buch; Evanthia Bernitsas; Ewart Mark Haacke; Yulin Ge; Yongsheng Chen Studying the relationship between cerebral oxygen utilization and cognitive...

Why are diseases more common in some parts of Europe than others, and why are northern Europeans taller than their southern counterparts? An international team of scientists say they have unearthed the answer in the DNA of ancient teeth and bones. The genes which protected our ancestors from...

Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells Significance On average, 13% of the T lymphocytes in the cerebrospinal fluid of people with the first symptoms of multiple sclerosis are specific for autologous...

https://www.sciencedirect.com/science/article/pii/S2589004223021612 Summary: Many autoimmune disorders exhibit flares in which symptoms erupt and then decline, as exemplified by multiple sclerosis (MS) in its relapsing-remitting form. Existing mathematical models of autoimmune flares often...

Risk of Multiple Sclerosis in People Living with HIV: An International Cohort Study Abstract Objective There has been interest in a possible negative association between HIV and multiple sclerosis (MS). We aimed to compare the risk of MS in a cohort of individuals living with HIV to that in...