multiple sclerosis

Abstract While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared CD11c+T-bet+ ABCs using models of Epstein-Barr virus (EBV)...

Abstract Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune...

Background: Individuals with multiple sclerosis (MS) are vulnerable to all types of infection, because MS itself involves immunodeficiency, in addition to involving treatment with immunosuppressants. Simple predictive variables for infection that are easily assessed in daily examinations are...

Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How? Morris G, Maes M, Murdjeva M, Puri BK The gammaretroviral human endogenous retrovirus (HERV) families MRSV/HERV-W and HERV-H (including the closely related HERV-Fc1) are associated with an increased risk of...

Open Access Published: 08 January 2023 Sequence similarity between SARS-CoV-2 nucleocapsid and multiple sclerosis-associated proteins provides insight into viral neuropathogenesis following infection Camille M. Lake & Joseph J. Breen Scientific Reports volume 13, Article number: 389 (2023)...

eta: obviously not a recommendation.

Highlights • Disability level (assessed by six-minute walk test) in people with multiple sclerosis was estimated using the data collected from wearable devices in free-living conditions. • Fitbit minute-level step counts were analysed from which features were extracted. • Elastic net, gradient...

Washington Post: Animalia Why this mammal eats its own brain — and why it could matter for you Dino Grandoni “It’s a crazy animal,” said Dechmann, a behavioral ecologist at the Max Planck Institute of Animal Behavior in Germany. “We can learn a lot from the shrews.” To prepare for the depths...

Abstract Background Recent empirical literature on autoimmune diseases has focused extensively on the implementation and evaluation of psychosocial interventions. Psychotherapy and counselling processes for multiple sclerosis (MS) have gained special attention given the cognitive and behavioral...

Full Title: Not all roads lead to the immune system: The Genetic Basis of Multiple Sclerosis Severity Implicates Central Nervous System and Mitochondria Involvement, 2022, Vilija G. Jokubaitis et al Abstract Multiple sclerosis (MS) is a leading cause of neurological disability in adults...

Abstract Background The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence...

New Research: How is neuromuscular fatigability affected by perceived fatigue and disability in people with multiple sclerosis?: Whereas fatigue is recognized to be the main complaint of patients with multiple sclerosis Whereas fatigue is recognized to be the main complaint of patients with...

Abstract Patients with multiple sclerosis acquire disability either through relapse-associated worsening (RAW) or progression independent of relapse activity (PIRA). This study addresses the relative contribution of relapses to disability worsening over the course of the disease, how early...

In conclusion, based on results from the genetic correlation and MR analyses, we demonstrated that moderate physical activity could causally decrease the risk of MS. These results could help better understand the role of physical activity in the pathogenesis of MS, and provided some lifestyle...

Abstract Background Exercise studies including only fatigued persons with multiple sclerosis (PwMS) with fatigue as primary endpoint are lacking. Objective To evaluate the effects of high-intensity resistance training (HIRT) on self-reported fatigue in fatigued PwMS in a single center randomised...

Multiple Sclerosis (MS) is a heterogeneous immune mediated disease of the central nervous system (CNS). Fatigue is one of the most common and disabling symptom of MS. It interferes with daily activities on the level of cognition and motor endurance. Motor fatigue can either result from lesions...

Abstract During the past decade, research has revealed that the vast community of micro-organisms that inhabit the gut — known as the gut microbiota — is intricately linked to human health and disease, partly as a result of its influence on systemic immune responses. Accumulating evidence...

https://www.nature.com/articles/s41579-022-00770-5 Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-established causal role in several cancers. Recent studies have provided compelling epidemiological and mechanistic evidence for a causal role of EBV in...

Abstract Background Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system...

Key clinical point: Women vs men with multiple sclerosis (MS) showed greater inflammatory disease activity up to menopausal age, whereas men vs women with MS showed greater disability accrual. Major finding: Women vs men had a 16% higher relapse rate and a higher estimated marginal mean of...