multiple sclerosis

  1. J

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis..., 2020, Nourbakhsh et al

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext
  2. J

    Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis, 2020 Probstel et al.

    https://immunology.sciencemag.org/content/5/53/eabc7191
  3. J

    Bifrontal transcranial direct current stimulation modulates fatigue in multiple sclerosis: a randomized sham-controlled study, Chalah, 2020

    https://link.springer.com/article/10.1007/s00702-020-02166-2
  4. J

    The Role of Ketamine Infusion for Patients with MS-Related Fatigue

    https://www.neurologyadvisor.com/topics/multiple-sclerosis/the-role-of-ketamine-infusion-for-patients-with-ms-related-fatigue/ Primary outcome of the study was negative. Reference Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine...
  5. Webdog

    Behavioral practices of patients with multiple sclerosis during Covid-19 pandemic, 2020, Alnajashi/Jabbad

    Full text: https://doi.org/10.1371/journal.pone.0241103241103 Study of 176 Multiple Sclerosis (MS) patients in Saudi Arabia. Spacing mine.
  6. Andy

    Immunometabolic profiling of T cells from .. relapsing-remitting [MS] .. impairment in glycolysis and mitochondrial respiration, 2017, Matarese et al

    Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
  7. Andy

    The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients, 2020, Knyszyńska et al

    Note: The term "chronic fatigue syndrome" is used often in this paper. As far as I can see the authors actually mean "chronic fatigue", which is why I have opened this thread in the "Health News and Research unrelated to ME/CFS" sub-forum, not elsewhere. Open access...
  8. J

    Regional microglial activation in the substantia nigra is linked with fatigue in MS, 2020, Singhal et al.

    https://nn.neurology.org/content/7/5/e854 Popular article here Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis? https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120
  9. Sly Saint

    Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities: Pust et al Aug 2020

    https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00811/full
  10. Andy

    A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome.., 2017, Morris et al

    Full title: A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause? Open access, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842501/
    • Andy
    • Thread
    • 2017 depression me/cfs morris multiple sclerosis neuroimaging paper spect white matter
    • Replies: 0
    • Forum: ME/CFS research
  11. J

    New MS Drug Approved — Ofatumumab is first self-administered, targeted B-cell treatment for relapsing MS

    Another drug for MS, still nothing for MECFS. https://www.medpagetoday.com/neurology/multiplesclerosis/88195
  12. J

    No Benefit of 3 Commonly Used Medications in MS Fatigue

    https://www.medscape.com/viewarticle/931397 might be paywalled
  13. J

    Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis–related fatigue, 2020, Fitzgerald et al

    Popular article https://multiplesclerosisnewstoday.com/news-posts/2020/07/07/pilot-randomized-active-placebo-controlled-trial-of-low-dose-ketamine-for-the-treatment-of-multiple-sclerosisrelated-fatigue/ Journal https://journals.sagepub.com/doi/abs/10.1177/1352458520936226?journalCode=msja
  14. Dolphin

    'Holy Grail' discovery could mean 'nobody needs to worry about their MS getting worse' – study

    Continues at: https://www.irishexaminer.com/world/arid-40027451.html Early days yet of course.
  15. Anna H

    Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier (2020) Sheikh et al

    https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01810-8 https://multiplesclerosisnewstoday.com/blood-factors-impair-metabolism-blood-brain-barrier-ms-study/ I thought this could be of interest, since one of Jarred Younger's upcoming studies is testing the hypothesis...
  16. Sly Saint

    Microbiome in Multiple Sclerosis; Where Are We, What We Know and Do Not Know : Boziki et al Apr 2020

    full paper: https://www.mdpi.com/2076-3425/10/4/234/htm
  17. Andy

    Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation, 2020, Bhargarva et al

    Open access, https://www.jci.org/articles/view/129401
  18. Mij

    Autonomic nervous system: a key player in prodromal multiple sclerosis?

    https://link.springer.com/article/10.1007/s10286-020-00676-3 Autonomic dysfunction, namely gastrointestinal, genitourinary, and cardiovascular abnormalities, is a key feature of the prodromal phase of other neurological disorders, such as Parkinson disease and other synucleinopathies [6]...
  19. Sly Saint

    How and for whom does supportive adjustment to multiple sclerosis cognitive-behavioural therapy work? A mediated moderation analysis - TC, RMM 2020

    How and for whom does supportive adjustment to multiple sclerosis cognitive-behavioural therapy work? A mediated moderation analysis KimberleyGoldsmitha1Joanna L.Hudsonb1TrudieChaldercLauraDennisondRona MossMorrisb https://www.sciencedirect.com/science/article/abs/pii/S0005796720300450...
  20. Woolie

    Response variability is associated with self-reported cognitive fatigue in multiple sclerosis, 2010, Bruce et al.

    I thought this piece of (oldish) research might be of interest to people interested in measuring cognitive dysfunction in ME. It notes that self reported fatigue in MS doesn't correlate well with actual cognitive performance measures (which is the same in ME). Here, they developed a new...
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