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Multiple sclerosis: Greater prevalence of disease activity in women and disability accrual in men

Discussion in 'Other health news and research' started by Mij, May 19, 2022.

  1. Mij

    Mij Senior Member (Voting Rights)

    Messages:
    8,204
    Key clinical point: Women vs men with multiple sclerosis (MS) showed greater inflammatory disease activity up to menopausal age, whereas men vs women with MS showed greater disability accrual.

    Major finding: Women vs men had a 16% higher relapse rate and a higher estimated marginal mean of annualized relapse rate (0.32 vs 0.28; P < .001); however, the difference disappeared after the age of 50 years. The deterioration in the Expanded Disability Status Scale (EDSS) points was higher in men vs women (0.065 vs 0.049 EDSS points per year; P = .0017), with men at a higher risk of reaching EDSS 4 ( P < .001).

    Study details: Findings are from an analysis of 9647 patients (3028 men and 6619 women) with MS from the Danish MS registry (DMSR) who received disease-modifying therapy and were followed-up for at least 1 year and two control visits.


    https://www.mdedge.com/neurology/ms...lerosis/multiple-sclerosis-greater-prevalence

    https://jnnp.bmj.com/content/early/2022/04/06/jnnp-2022-328994

     

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