Highlights
Hypoxia inducible factors – mitochondria crosstalk underlies adaptations to hypoxia.
Controlled induction of hypoxia responses yields potent health benefits.
Environmental and behavioral conditions modulate adaptations to hypoxia.
Understanding the determinants of adaptation...
Matrix stiffening promotes perinuclear clustering of mitochondria
Piyush Daga; Basil Thurakkal; Simran Rawal; Tamal Das
Mechanical cues from the tissue microenvironment, such as the stiffness of the extracellular matrix, modulate cellular forms and functions. As numerous studies have shown...
Mitochondria- and ER-associated actin are required for mitochondrial fusion
Priya Gatti; Cara R Schiavon; Uri Manor; Marc Germain
Mitochondria play a crucial role in the regulation of cellular metabolism and signalling. Mitochondrial activity is modulated by the processes of mitochondrial...
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact
Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...
The authors argue that the commonly used terms 'mitochondrial function and mitochondrial dysfunction' do not do justice to the diverse mitochondrial features, activities, functions and behaviours within the cells, and thus call for the field to adopt more specific terminology in the context of...
Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19
Huynh, Tin Van; Rethi, Lekha; Lee, Ting-Wei; Higa, Satoshi; Kao, Yu-Hsun; Chen, Yi-Jen
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to...
Significance
Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a...
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, Christina H.; Zhang, Ying E.
Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early...
Abstract
During maximal exercise healthy humans increase their oxygen uptake (V̇O2) 10 to 20-fold that measured at rest to as much as 6 L/min. At the molecular level the numbers are staggering: Each minute the exercising O2 transport system - lungs, cardiovascular and active muscles – must...
https://www.mdpi.com/2218-273X/11/2/173/htm
Abstract
Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in...
Mitochondrial signal transduction
Picard M, Shirihai OS
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that...
Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
Allen CNS, Arjona SP, Santerre M, Sawaya BE
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for...
via
Dr. Marc-Alexander Fluks
Source: Cornell University Date: May 2022 URL: https://ecommons.cornell.edu/handle/1813/111644
https://ecommons.cornell.edu/bitstream/handle/1813/111644/Pandey_cornell_0058O_11430.pdf
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and mitochondria: A...
Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder
Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...
electron microscopy
immune dysfunction
lipid droplets
lipid metabolism
lipids
mitochondriamitochondrial architecture
omf
open medicine foundation
ron davis
smpd1
sphingolipids
t cells
Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2
Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan
The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is...
Abstract
Oocytes form before birth and remain viable for several decades before fertilization1. Although poor oocyte quality accounts for most female fertility problems, little is known about how oocytes maintain cellular fitness, or why their quality eventually declines with age2. Reactive...
Full title: SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19
Mitochondria get caught in the crossfire of coronavirus disease 2019 (COVID-19) and antiviral immunity...
Post has been moved from the "United Kingdom: ME Association news" thread
Mitochondrial dysfunction in Long Covid and ME/CFS
David Systrom, a pulmonary and critical care doctor at Brigham & Women’s Hospital, Boston, believes he has found answers through studying patients with ME/CFS, an...
Abstract
Importance Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A is a natural gut microbiome–derived food metabolite that has been shown to stimulate mitophagy and improve muscle function in older animals and to induce mitochondrial...
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