mitochondria

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...

Mitochondria and oxygen homeostasis Mateus P. Mori; Rozhin Penjweini; Jay R. Knutson; Ping-yuan Wang; Paul M. Hwang Molecular oxygen possesses a dual nature due to its highly reactive free radical property: it is capable of oxidizing metabolic substrates to generate cellular energy, but can...

Exercise and vascular function in sedentary lifestyles in humans Fasipe, Babatunde; Li, Shunchang; Laher, Ismail People with sedentary lifestyles engage in minimal or no physical activity. A sedentary lifestyle promotes dysregulation of cellular redox balance, diminishes mitochondrial function...

Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity https://www.nature.com/articles/s41598-023-35896-w Published: 12 July 2023 Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic multisymptom illness, and a...

Highlights Hypoxia inducible factors – mitochondria crosstalk underlies adaptations to hypoxia. Controlled induction of hypoxia responses yields potent health benefits. Environmental and behavioral conditions modulate adaptations to hypoxia. Understanding the determinants of adaptation...

Matrix stiffening promotes perinuclear clustering of mitochondria Piyush Daga; Basil Thurakkal; Simran Rawal; Tamal Das Mechanical cues from the tissue microenvironment, such as the stiffness of the extracellular matrix, modulate cellular forms and functions. As numerous studies have shown...

Mitochondria- and ER-associated actin are required for mitochondrial fusion Priya Gatti; Cara R Schiavon; Uri Manor; Marc Germain Mitochondria play a crucial role in the regulation of cellular metabolism and signalling. Mitochondrial activity is modulated by the processes of mitochondrial...

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...

The authors argue that the commonly used terms 'mitochondrial function and mitochondrial dysfunction' do not do justice to the diverse mitochondrial features, activities, functions and behaviours within the cells, and thus call for the field to adopt more specific terminology in the context of...

Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19 Huynh, Tin Van; Rethi, Lekha; Lee, Ting-Wei; Higa, Satoshi; Kao, Yu-Hsun; Chen, Yi-Jen Background: COVID-19 has a major impact on cardiovascular diseases and may lead to...

Medical Research Foundation https://www.medicalresearchfoundation.org.uk/news/the-role-of-mitochondria-in-parkinsons-disease

Significance Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a...

Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment Stuelten, Christina H.; Zhang, Ying E. Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early...

Abstract During maximal exercise healthy humans increase their oxygen uptake (V̇O2) 10 to 20-fold that measured at rest to as much as 6 L/min. At the molecular level the numbers are staggering: Each minute the exercising O2 transport system - lungs, cardiovascular and active muscles – must...

https://www.mdpi.com/2218-273X/11/2/173/htm Abstract Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in...

Mitochondrial signal transduction Picard M, Shirihai OS The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that...

Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis Allen CNS, Arjona SP, Santerre M, Sawaya BE Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for...

via Dr. Marc-Alexander Fluks Source: Cornell University Date: May 2022 URL: https://ecommons.cornell.edu/handle/1813/111644 https://ecommons.cornell.edu/bitstream/handle/1813/111644/Pandey_cornell_0058O_11430.pdf Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and mitochondria: A...

Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022 — Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...

Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV‐2 Artem Pliss, Andrey N. Kuzmin, Paras N. Prasad, Supriya D. Mahajan The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is...