Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise
Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
See post #76 for peer-reviewed version.
Indistinguishable mitochondrial phenotypes after exposure of healthy myoblasts to myalgic encephalomyelitis or control serum
Audrey A. Ryback, Charles Hillier, Camila M Loureiro, Chris P Ponting, Caroline F Dalton
Myalgic Encephalomyelitis (ME)/Chronic...
https://www.mdpi.com/1422-0067/26/11/5339#
Open Access
Article
Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
by
Barbara Hochecker
1,*,
Katja Matt
1,
Melanie Scherer
1,
Alica Meßmer
1,
Alexander von Ardenne
2...
The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction.
Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...
Natural polyphenol boosts mitochondrial function and muscle performance during aging
I recently started taking olive leaf extract for quite different reasons before I found this, so it will be interesting to see if it has any other beneficial effects.
Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity
Yuzhou Zeng; Anna Antoniou
Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...
Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19
Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...
Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang
ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
Rhodoquinone carries electrons in the mammalian electron transport chain
Jonathan Valeros et 31 al.
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O2). In hypoxia...
A Comprehensive Review of the Contribution of Mitochondrial DNA Mutations and Dysfunction in Polycystic Ovary Syndrome, Supported by Secondary Database Analysis
Kobayashi, Hiroshi; Matsubara, Sho; Yoshimoto, Chiharu; Shigetomi, Hiroshi; Imanaka, Shogo
Polycystic ovary syndrome (PCOS) is a...
Highlights
• Dengue and Zika viruses alter endoplasmic reticulum-mitochondria contact sites (ERMC)
• Mitochondrial respiration is perturbed over the course of the infection
• ERMC protein knockdown increases viral replication
• ERMC proteins RRBP1 and SYNJ2BP regulate Zika virus-induced cell...
Abstract
Mitochondria are essential in supplying energy to skeletal muscle. Near-infrared spectroscopy (NIRS) was developed to noninvasively assess mitochondrial capacity (mV̇O2max) as a rate constant of metabolic recovery after exercise.
Purpose
This study measured the time course mV̇O2max...
(masters thesis)
Background: Post-COVID (PC) is characterized by prolonged symptoms following a COVID-19 infection, with Post-Exertional Malaise (PEM) being a feature with a large negative impact on quality of life. Mitochondrial dysfunction has previously been related to PEM-related symtpoms...
1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID
Lucy E. M. Finnigan, Mark Philip Cassar, Mehrsa Jafarpour, Antonella Sultana, Zakariye Ashkir, Karim Azer, Stefan Neubauer, Damian J. Tyler, Betty Raman, Ladislav Valkovič
Background
Emerging evidence suggests...
Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging
Gopal V Velmurugan; Hemendra J Vekaria; Samir P Patel; Patrick G Sullivan; W Brad Hubbard
Intercellular mitochondrial transfer (IMT) is an intriguing biological phenomenon where mitochondria...
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