mitochondria

Abstract Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis1. Distinct metabolic and mitochondrial features guide the activation and the diverse functional states of myeloid cells2...

Full title: Comparison of the muscle oxygenation during submaximal and maximal exercise tests in patients post-coronavirus disease 2019 syndrome with pulmonary involvement ABSTRACT Introduction Pulmonary involvement is prevalent in patients with coronavirus disease 2019 (COVID-19). Arterial...

https://www.sciencedirect.com/science/article/abs/pii/S0306456524000317 Journal of Thermal Biology Available online 21 February 2024, 103813 In Press, Journal Pre-proof Heat treatment in health and disease: How water-filtered infrared-A (wIRA irradiation affects key cellular mechanisms in...

Abstract Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not...

Polysomnography has shown that I have Periodic Limb Movement Disorder (PLMD). I also tick all boxes for RLS (and never been diagnosed with fibromyalgia). I can't describe how happy I was to see, written in black and white, numerically quantified, accompanied by "obviously [patient] has PLMD that...

Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection Dirajlal-Fargo; Maison; Durieux; Andrukhiv; Funderburg; Ailstock; Gerschenson; Mccomsey Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo...

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...

A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome. Rehan Khan; Weizhen Ji; Jeisac Guzman-Rivera; Abhilasha Madhvi; Tracy Andrews; Benjamin Richlin; Christian Suarez; Sunanda Gaur; William Cuddy; Aalok R...

Functional and Morphological Differences of Muscle Mitochondria in Chronic Fatigue Syndrome and Post-COVID Syndrome Bizjak, Daniel Alexander; Ohmayer, Birgit; Buhl, Jasmine Leonike; Schneider, Elisabeth Marion; Walther, Paul; Calzia, Enrico; Jerg, Achim; Matits, Lynn; Steinacker, Jürgen Michael...

Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight Anurag Sakharkar; Kiven Erique Lukong; Lauren M Sanders; Sylvain V Costes; Jian Yang; Changiz Taghibiglou Space exploration has captured the imagination of humanity for generations. From the first steps on the moon to...

Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome ABSTRACT NUMBER: 2546 Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome Lakshmanan Suresh1, Julian Ambrus2, Long Shen3 and Sahana Vishwanath4, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2100 High St...

Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network Lee, Richard G.; Rudler, Danielle L.; Raven, Samuel A.; Peng, Liuyu; Chopin, Anaëlle; Moh, Edward S. X.; McCubbin, Tim; Siira, Stefan J.; Fagan, Samuel V.; DeBono, Nicholas J.; Stentenbach, Maike...

The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases Hu, Cuilan; Shi, Zheng; Liu, Xiongxiong; Sun, Chao Mitochondria are double-membrane organelles that are involved in energy production, apoptosis, and signaling in eukaryotic cells...

The Role Of Α7 Nicotinic Acetylcholine Receptors In Post-Acute Sequelae Of Covid-19 Skok Post-Acute Sequelae of COVID-19 or Long COVID becomes evident some weeks to months following acute COVID-19. Symptoms include cognitive impairment and varying degrees of memory loss with no definitive...

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19 Deepthi Ashok; Ting Liu; Joseph Criscione; Meghana Prakash; Byunggik Kim; Julian Chow; Morgan Craney; Kyriakos Papanicolaou; Agnieszka Sidor; D. Brian Foster; Andrew Pekosz...

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview Mantle, David; Hargreaves, Iain Parry; Domingo, Joan Carles; Castro-Marrero, Jesus Post-viral fatigue syndrome (PVFS) encompasses a wide range of complex neuroimmune disorders of unknown...

The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics Pileggi; Parmar; Elkhatib; Stewart; Alecu; Côté; Bennett; Sandhu; Cuperlovic-Culf; Harper SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence...

Summary We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed...

Mitochondrial morphology and function in mitochondrial disease Julie Faitg; Tracey Davey; Ross Laws; Conor Lawless; Helen Tuppen; Eric Fitton; Doug Elizabeth Turnbull; Amy Elizabeth Vincent Mitochondria play a crucial role in maintaining cellular health. It is interesting that the shape of...

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity Vermeulen, Ruud CW; Kurk, Ruud M; Visser, Frans C; Sluiter, Wim; Scholte, Hans R Background The aim of this study was to investigate...