mitochondria

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria Ryu, Keun Woo; Fung, Tak Shun; Baker, Daphne C.; Saoi, Michelle; Park, Jinsung; Febres-Aldana, Christopher A.; Aly, Rania G.; Cui, Ruobing; Sharma, Anurag; Fu, Yi; Jones, Olivia L.; Cai, Xin; Pasolli, H. Amalia...

Novel biomarkers of mitochondrial dysfunction in Long COVID patients Szögi, Titanilla; Borsos, Barbara N.; Masic, Dejana; Radics, Bence; Bella, Zsolt; Bánfi, Andrea; Ördög, Nóra; Zsiros, Csenge; Kiricsi, Ágnes; Pankotai-Bodó, Gabriella; Kovács, Ágnes; Paróczai, Dóra; Botkáné, Andrea Lugosi...

KEY POINTS Question: Determine the short- and long-term physical impairments and skeletal muscle cellular changes in survivors of critical COVID. Findings: Survivors of critical COVID have high prevalence of weakness, fatigue, and reduced functional exercise capacity with muscle tissue...

Editor’s summary Increased plasma creatine is associated with type 2 diabetes, but causation has not been established. Rizo-Roca et al. show that men with type 2 diabetes had increased plasma creatine and decreased muscle phosphocreatine, which was associated with poor glucose handling. In...

https://www.sciencedirect.com/science/article/abs/pii/S0960896624003353 571P Muscular metabolic plasticity in 3D in vitro models against systemic stress factors in ME/CFS and long COVID-19 Author links 1 Institute For Bioengineering Of Catalonia BIST, Barcelona, Spain 2 ICREA Institució...

https://www.researchsquare.com/article/rs-4654793/v1 Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity Chiara Macchi1 Andrea Giachi1 Isabella Fichtner1 Silvia Pedretti1 Piercarlo Sarzi Puttini2 Nico Mitro1 Alberto...

Numerous people are being diagnosed as having CFS and fibro after apparent remission of sarcoidosis. Numerous questions arise 1) What does the diagnoser know about CFS or fibro? 2) What does the diagnoser know about work on post sarcoid fatigue vs sarcoid e.g. persistent shift to TH1 in post...

ABSTRACT Dengue virus (DENV) infection is known to affect host cell metabolism, but the molecular players involved are still poorly known. Using a proteomics approach, we identified six DENV proteins associated with mitochondria isolated from infected hepatocytes, and most of the peptides...

Abstract OBJECTIVES: The pathogenesis of fibromyalgia (FM), characterised by chronic widespread pain and fatigue, remains notoriously elusive, hampering attempts to develop disease modifying treatments. Mitochondria are the headquarters of cellular energy metabolism, and their malfunction has...

Link to article By David Cox

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST Hans-Georg Sprenger; Melanie J. Mittenbühler; Yizhi Sun; Jonathan G. Van Vranken; Sebastian Schindler; Abhilash Jayaraj; Sumeet A. Khetarpal; Ariana Vargas-Castillo; Anna M. Puszynska; Jessica...

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses Paola Pinto-Hernandez; Manuel Fernandez-Sanjurjo; Daan Paget; Xurde M Caravia; David Roiz-Valle; Juan Castilla-Silgado; Sergio Diez-Robles; Almudena Coto-Vilcapoma; Pau Gama; Pablo M Garcia-Roves...

https://www.hindawi.com/journals/crig/2024/6475425/ Full title: Mitochondrial DNA Missense Mutations ChrMT: 8981A > G and ChrMT: 6268C > T Identified in a Caucasian Female with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Triggered by the Epstein–Barr Virus Abstract Myalgic...

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis More than 65...

Subcellular imaging of lipids and sugars using genetically encoded proximity sensors William M. Moore; Roberto J. Brea; Caroline Knittel; Ellen Wrightsman; Brandon Hui; Jinchao Loui; Christelle F. Ancajas; Michael D. Best; Neal K. Devaraj; Itay Budin Live cell imaging of lipids and other...

Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches Molnar, Tihamer; Lehoczki, Andrea; Fekete, Monika; Varnai, Reka; Zavori, Laszlo; Erdo-Bonyar, Szabina; Simon, Diana; Berki, Tímea; Csecsei, Peter; Ezer, Erzsebet The COVID-19 pandemic, caused...

Preprint Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases Abstract GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its...

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome T. Pietrangelo; R. Mancinelli; L. Toniolo; G. Montanari; J. Vecchiet; G. Fanò; S. Fulle Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that...

SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...

Mitochondrial quality control pathways sense mitochondrial protein import Laurie P. Lee-Glover; Timothy E. Shutt Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from...