metabolism

  1. SNT Gatchaman

    Genetics of circadian rhythms and sleep in human health and disease, 2022, Lane et al

    Genetics of circadian rhythms and sleep in human health and disease Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena R Circadian rhythms and sleep are fundamental biological processes integral to human health. Their disruption is associated with detrimental physiological consequences...
  2. RedFox

    Using an untargeted metabolomics approach to analyze serum metabolites in COVID-19 patients with nucleic acid turning negative

    Hot off the press, just published today in Frontiers in Pharmacology. A group of researchers in China used metabolomics (measuring the concentration of many metabolism-related chemicals in the blood) to compare healthy controls with Covid-19 patients who were admitted to Jiaxing Hospital, but...
    • RedFox
    • Thread
    • amino acids covid-19 fatty acid metabolism metabolism metabolomics
    • Replies: 1
    • Forum: Long Covid research
  3. SNT Gatchaman

    Lactate: the ugly duckling of energy metabolism, 2020, Rabinowitz and Enerbäck

    Lactate: the ugly duckling of energy metabolism Rabinowitz JD, Enerbäck S Lactate, perhaps the best-known metabolic waste product, was first isolated from sour milk, in which it is produced by lactobacilli. Whereas microbes also generate other fermentation products, such as ethanol or acetone...
  4. leokitten

    Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19, 2022, Karagiannis et al

    https://www.nature.com/articles/s41586-022-05128-8
  5. SNT Gatchaman

    Circulating FGF21 proteolytic processing mediated by fibroblast activation protein, 2016, Zhen et al

    Circulating FGF21 proteolytic processing mediated by fibroblast activation protein Eugene Y. Zhen, Zhaoyan Jin, Bradley L. Ackermann, Melissa K. Thomas, Jesus A. Gutierrez Fibroblast growth factor 21 (FGF21), a hormone implicated in the regulation of glucose homoeostasis, insulin sensitivity...
  6. SNT Gatchaman

    Going Back to the Biology of FGF21: New Insights, 2019, Lewis et al

    Going Back to the Biology of FGF21: New Insights Jo E. Lewis, Francis J.P. Ebling, Ricardo J. Samms, Kostas Tsintzas Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple...
  7. A

    Brain Memory Signals Linked to Blood Sugar Levels

    An article from neuroscience news . Interesting in the metabolism link , given we know of issues with glucose in ME. https://neurosciencenews.com/hippocampal-memory-blood-sugar-19108/amp/
  8. Kitty

    Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of Warburg Effect in Cancer & Other [...], 2021, Proal & VanElzakker

    Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions Amy D. Proal and Michael B. VanElzakker, 2021 This hypothesis piece discusses metabolic shift in a broad range of chronic conditions, but as it...
    • Kitty
    • Thread
    • intracellular infection metabolic shift metabolism pathogen-driven metabolic changes warburg effect
    • Replies: 1
    • Forum: ME/CFS research
  9. leokitten

    Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive. Treadway MT et al. Trends Cogn Sci. (2019)

    Interesting review of research on the impact of inflammation on the dopamine system as well as a theoretical model and computational method trying to connect it all. Could be a hypothesis as to why Abilify and dopaminergic agents have some partial efficacy in ME, even if it is temporary (so...
  10. Sly Saint

    A SWATH-MS analysis of ME/CFS peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction: Sweetman,Vallings,Tate et al Aug 2020

    A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction https://www.researchsquare.com/article/rs-52172/v1
    • Sly Saint
    • Thread
    • 2020 me/cfs metabolism mitochondria mitochondrial dysfunction paper peroxiredoxin proteomics ros vallings sweetman warren tate
    • Replies: 17
    • Forum: ME/CFS research
  11. Andy

    Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury, 2020, Greco et al

    In rats. Open access, https://www.sciencedirect.com/science/article/pii/S0014488620301205
  12. Sly Saint

    Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations - [new article 2020]

    Basal glycolysis is reduced in ME/CFS CD4+ T cells. https://www.jci.org/articles/view/132185/figure/4 paper from December 2019 https://www.jci.org/articles/view/132185 new Article by Mady Hornig https://www.jci.org/articles/view/134985
    • Sly Saint
    • Thread
    • 2020 article cytokines glycolysis hornig me/cfs metabolism paper t cells
    • Replies: 5
    • Forum: ME/CFS research
  13. Sly Saint

    Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids: Levine,Hanson et al 2020

    Article. PDF Received: 20 December 2019; Accepted: 12 January 2020; Published: 14 January 2020...
    • Sly Saint
    • Thread
    • 2020 acyl lipids bile acid circulation levine maureen hanson me/cfs metabolism metabolomics paper sphingolipids steroids susan levine
    • Replies: 40
    • Forum: ME/CFS research
  14. Trish

    Is ME a metabolic problem or a signalling problem?

    I am trying to get my head around the question of whether ME could be a metabolic problem, as suggested by the 'something in the blood' findings by several different researchers, and by the problems with pyruvate dehydrogenase possibly blocking or reducing complete breakdown of glucose, and by...
  15. Sly Saint

    Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health - Parker,Fonseca,Carding Aug 2019

    https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1638722
  16. Sly Saint

    Importance of fatigue and its measurement in chronic liver disease - Gerber et al Jul 28 2019

    Opinion Piece Abstract seemed well thought out... until the last bit open access https://www.wjgnet.com/1007-9327/full/v25/i28/3669.htm
  17. MSEsperanza

    Motor Cortex Function in Fibromyalgia. De Tommaso et al (2019)

    Eleonora Gentile, Katia Ricci, Marianna Delussi, Filippo Brighina, and Marina de Tommaso, “Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy,” Pain Research and Treatment, vol. 2019, https://doi.org/10.1155/2019/2623161...
  18. H

    Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response (2019) Naviaux

    https://www.ncbi.nlm.nih.gov/pubmed/31083530 https://www.mdpi.com/2079-7737/8/2/27/htm This research is not explicitly about ME/CFS but I decided to put it here anyway because it's about CDR and because of the acknowledgements in the full paper:
    • hixxy
    • Thread
    • 2019 ageing cdr me/cfs metabolism mitochondria naviaux paper
    • Replies: 13
    • Forum: ME/CFS research
  19. Andy

    Gut bacteria signaling to mitochondria in intestinal inflammation and cancer, 2019, Jackson and Theiss

    Open access at https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1592421
    • Andy
    • Thread
    • colitis-associated cancer colon cancer inflammatory bowel disease metabolism microbiome mitochondria
    • Replies: 0
    • Forum: Other health news and research
  20. K

    Reduced Metabolism in Nematodes linked to the Immune System

    Perhaps not that interesting of a read but it is a very interesting discovery for people with ME. You may recall the metabolomics study of 2017 that found that our profile was the same as dauer - a reduced metabolic (hibernation like) state in nematode worms. Well this research has found that...
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