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Genetics of circadian rhythms and sleep in human health and disease, 2022, Lane et al

Discussion in 'Other health news and research' started by SNT Gatchaman, Aug 31, 2022.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

    Aotearoa New Zealand
    Genetics of circadian rhythms and sleep in human health and disease
    Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena R

    Circadian rhythms and sleep are fundamental biological processes integral to human health. Their disruption is associated with detrimental physiological consequences, including cognitive, metabolic, cardiovascular and immunological dysfunctions. Yet many of the molecular underpinnings of sleep regulation in health and disease have remained elusive.

    Given the moderate heritability of circadian and sleep traits, genetics offers an opportunity that complements insights from model organism studies to advance our fundamental molecular understanding of human circadian and sleep physiology and linked chronic disease biology.

    Here, we review recent discoveries of the genetics of circadian and sleep physiology and disorders with a focus on those that reveal causal contributions to complex diseases.

    PubMed | Nature Reviews Genetics (paywall)
    Mij, Peter Trewhitt and RedFox like this.

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