inflammation

https://www.medrxiv.org/content/10.1101/2021.09.21.21263845v2 Abstract While significant attention has been paid to the immunologic determinants of disease states associated with COVID-19, their contributions to post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of...

Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes. A putative dysregulation of the immune-brain axis, the coagulation process, and auto-inflammation to...

Long-term cardiac pathology in individuals with mild initial COVID-19 illness Valentina O. Puntmann, Simon Martin, Anastasia Shchendrygina, Jedrzej Hoffmann, Mame Madjiguène Ka, Eleni Giokoglu, Byambasuren Vanchin, Niels Holm, Argyro Karyou, Gerald S. Laux, Christophe Arendt, Philipp De Leuw...

Galectins at a glance Ludger Johannes, Ralf Jacob, Hakon Leffler Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis...

The Emerging Application of Itaconate: Promising Molecular Targets and Therapeutic Opportunities Jiaqi Lin, Jinxuan Ren, Dave Schwinn Gao, Yi Dai, Lina Yu Metabolites have recently been found to be involved in significant biological regulation and changes. Itaconate, an important intermediate...

Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology Eva K Hejbøl, Thomas Harbo, Jane Agergaard, Line B Madsen, Thomas H Pedersen, Lars J Østergaard, Henning Andersen, Henrik D Schrøder, Hatice Tankisi Background: Among post-COVID-19...

Abstract Objectives: Studies have demonstrated immune dysfunction in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, evidence is varied. The current study used network analysis to examine relationships between cytokines among a sample of pediatric...

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (Non peer-reviewed) Jae Kyu Ryu, Elif G Sozmen, Karuna Dixit, Mauricio Montano, Yusuke Matsui, Yixin Liu, Ekram Helmy, Thomas J Deerinck, Zhaoqi Yan, Renaud Schuck, Rosa Meza Acevedo, Collin M...

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00127-8/fulltext The PHOSP-COVID Collaborative Group Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study...

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel...

Platelets amplify endotheliopathy in COVID-19 Tessa J. Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina C. Rolling, Yuhe Xia, Kamelia Drenkova1, Antoine Biebuyck, Alexander T. Fields, Michael Tawil, Elliot Luttrell-Williams, Eugene Yuriditsky, Grace Smith, Paolo Cotzia, Matthew D. Neal...

Full title: Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner In mice. Highlights • Butyrate inhibits the production of TNF-α, IL-6 and IL-12 in macrophages. • Butyrate inhibits NF-κB...

https://www.cell.com/cell/pdf/S0092-8674(21)01223-X.pdf Research done in mice. Highlights Neuronal ensembles in the InsCtx are activated during peripheral inflammation Reactivation of these neurons is sufficient to retrieve peripheral inflammation These InsCtx neurons project to autonomic...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the pandemic Coronavirus Disease 2019 (COVID-19) and now many face the burden of prolonged symptoms—long-lasting COVID-19 symptoms or “long-COVID”. Long-COVID is thought to be linked to immune dysregulation due to harmful...

Abstract Although most patients recover from acute COVID-19, some experience postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of PASC is a syndrome called “long COVID-19,” reminiscent of myalgic encephalomyelitis/chronic fatigue syndrome...

Activation of endogenous retroviruses during brain development causes an inflammatory response Marie E Jönsson, Raquel Garza, Yogita Sharma, Rebecca Petri, Erik Södersten, Jenny G Johansson, Pia A Johansson, Diahann AM Atacho, Karolina Pircs, Sofia Madsen, David Yudovich, Ramprasad...

Full title: The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups https://www.preprints.org/manuscript/202101.0623/v1

https://www.huffingtonpost.co.uk/entry/covid-tongue-explained_uk_60016507c5b62c0057bc0be2?ncid=fcbklnkukhpmg00000001&fbclid=IwAR3KZkyFOqPM2vuwSrM_MVSvLoAM-U4nInQ5UtnlL3LzXEwPJYhWmlzOa4g&guccounter=1&guce_referrer=aHR0cHM6Ly9sLmZhY2Vib29rLmNvbS8&guce_referrer_sig=AQAAAGa517_TqWUBcV_ZrgqWanMDO6DeMe...

Lately I've been having attacks of red itchy inflammation. It doesn't look too bad on the pictures but it's sore and sometimes itches tremendously. I have very severe ME and although I've had very little light sensitivity, my sound sensitivity is worse and my touch sensitivity even worse. Having...

I'm asking this because this is what triggered a severe worsening of my symptoms at the time. It coincided with sporadic serum hyperpotassemia but no test or swap had been done on infections.