The Reification of the Clinical Diagnosis of ME/CFS as an Immune and Oxidative Stress Disorder: 2021, Maes et al

John Mac · Jan 29, 2021

Full title:
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

Abstract
The approach towards myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) remains in a permanent state of crisis with fierce competition between the psychosocial school, which attributes ME/CFS to the perception of effort, and the medical approach (Maes and Twisk, BMC Med, 2010,8,35).

The aim of this paper is to review how to construct a nomothetic model of ME/CFS using Partial Least Squares (PLS) path analysis and ensembling causome (bacterial translocation as assessed with IgM/IgA responses to LPS), protectome (lowered coenzyme Q10), adverse outcome pathways (AOP) including increased lysozyme, CD38+ T cell activation, cell-mediated immune activation (CMI), and IgM responses to oxidative specific epitopes and NO-adducts (IgM OSENO).

Using PLS, we trained, tested and validated this knowledge- and data-driven causal ME/CFS model, which showed adequate convergence, construct and replicability validity.
This bottom-up explicit data model of ME/CFS objectivates the descriptive narratives of the ME/CFS phenome, using causome-protectome-AOP data, whereby the abstract concept ME/CFS is translated into pathways, thereby securing the reification of the ME/CFS phenome.

We found that 31.6% of the variance in the physiosomatic symptom dimension of ME/CFS was explained by the cumulative effects of CMI and CD38+ activation, IgM OSENO, IgA LPS, lysozyme (all positive) and coenzyme Q10 (inversely).
Cluster analysis performed on the PLS-generated latent vector scores of all feature sets exposed three distinct immune groups of ME/CFS, namely one with increased lysozyme, one with increased CMI + CD38 activation + depressive symptoms, and another with increased bacterial translocation + autoimmune responses to OSENO.
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https://www.preprints.org/manuscript/202101.0623/v1

Amw66 · Jan 29, 2021

John Mac said: ↑

Full title:
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

https://www.preprints.org/manuscript/202101.0623/v1

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How do these three distinct groups relate to Youngers etc ?

Jonathan Edwards · Jan 29, 2021

Amw66 said: ↑

How do these three distinct groups relate to Youngers etc ?
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I wouldn't worry, the abstract indicates that this is pseudoscientific rambling and nothing more.
Claiming that a few correlations can magically be turned into 'reification' using abstruse terms and methods gets us nowhere.

Kitty · Jan 29, 2021

Jonathan Edwards said: ↑

I wouldn't worry, the abstract indicates that this is pseudoscientific rambling and nothing more.
Click to expand...

It does read as if someone's been trying to teach their AI to draft articles in preparation for the beginning of April.

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