complement

  1. SNT Gatchaman

    Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population, 2018, Gaya da Costa et al.

    Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population Gaya da Costa, Mariana; Poppelaars, Felix; van Kooten, Cees; Mollnes, Tom E.; Tedesco, Francesco; Würzner, Reinhard; Trouw, Leendert A.; Truedsson, Lennart; Daha, Mohamed R.; Roos, Anja...
  2. SNT Gatchaman

    SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications

    SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Zhouyi Rong; Hongcheng Mai; Saketh Kapoor; Victor Puelles; Jan Czogalla; Julia Schaedler; Jessica Vering; Claire Delbridge; Hanno Steinke...
    • SNT Gatchaman
    • Thread
    • bone marrow brain coagulation complement long covid meninges neurological disorder neurological symptoms sars-cov-2 skull spike protein viral persistence
    • Replies: 14
    • Forum: Long Covid research
  3. SNT Gatchaman

    Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination, 2022, Irrgang et al

    Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination Pascal Irrgang, Juliane Gerling, Katharina Kocher, Dennis Lapuente, Philipp Steininger, Katharina Habenicht, Monika Wytopil, Stephanie Beileke, Simon Schäfer, Jahn Zhong, George...
  4. Sly Saint

    Unravelling the nature of postexertional malaise in ME/CFS: the role of elastase, complement C4a and interleukin-1β 2010, Nijs et al

    Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β Abstract Abstract. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Frémont M, Paul L (Vrije Universiteit Brussel...
    • Sly Saint
    • Thread
    • 2010 belgium c4a complement elastin il-1b il-1ß me/cfs nijs paper pem
    • Replies: 9
    • Forum: ME/CFS research
  5. LarsSG

    Distinguishing features of Long COVID identified through immune profiling, 2022, Klein, Iwasaki et al

    Abstract SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID. Individuals diagnosed with Long COVID frequently report unremitting fatigue, post-exertional malaise, and a...
    • LarsSG
    • Thread
    • april complement cortisol ebv epstein-barr etiology galectin iwasaki long covid mental health as risk factor mount sinai medical centre no link with pre-existing mental illness putrino risk factors virology virology blog
    • Replies: 57
    • Forum: Long Covid research
  6. wastwater

    COVID-19: A collision of complement, coagulation and inflammatory pathways, 2020, Chauhan et al

    https://onlinelibrary.wiley.com/doi/10.1111/jth.14981 Parallels with systemic inflammatory disorders such as atypical hemolytic uremic syndrome (aHUS) have implicated the complement pathway in the pathogenesis of COVID-19, and particularly the anaphylatoxins C3a and C5a released from cleavage...
  7. SNT Gatchaman

    Premortem skin biopsy assessing microthrombi, IFN I antiviral & regulatory proteins and complement correlates with Covid19 clinical stage, 2022

    Premortem Skin Biopsy Assessing Microthrombi, Interferon I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage Jeffrey Laurence, Gerard Nuovo, Sabrina E. Racine-Brzostek, Madhav Seshadri, Sonia Elhadad, A. Neil Crowson, J. Justin...
  8. SNT Gatchaman

    Neurovascular injury with complement activation and inflammation in COVID-19, 2022, Lee ... Nath et al

    Neurovascular injury with complement activation and inflammation in COVID-19 Myoung-Hwa Lee, Daniel P. Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N. Stram, Joel T. Moncur, Marco Hefti, Rebecca D. Folkerth...
    • SNT Gatchaman
    • Thread
    • brain complement covid-19 fibrinogen immune complexes long covid microcirculation microclots post-mortem
    • Replies: 18
    • Forum: Long Covid research
  9. SNT Gatchaman

    [Preprint] SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy, Ryu et al, 2021

    SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy (Non peer-reviewed) Jae Kyu Ryu, Elif G Sozmen, Karuna Dixit, Mauricio Montano, Yusuke Matsui, Yixin Liu, Ekram Helmy, Thomas J Deerinck, Zhaoqi Yan, Renaud Schuck, Rosa Meza Acevedo, Collin M...
    • SNT Gatchaman
    • Thread
    • complement covid-19 fibrin fibrinogen inflammation sars-cov-2 spike protein thrombosis
    • Replies: 10
    • Forum: Long Covid research
  10. SNT Gatchaman

    SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19, 2021, Grobbelaar et al

    SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 Lize M. Grobbelaar, Chantelle Venter, Mare Vlok, Malebogo Ngoepe, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp, Douglas B. Kell and Etheresia...
  11. Hutan

    Transcriptional Control of Complement Activation in an Exercise Model of CFS, 2009, Sorensen et al

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583111/ Abstract Complement activation resulting in significant increases of C4a split product may be a marker of postexertional malaise in individuals with chronic fatigue syndrome (CFS). This study focused on identification of the transcriptional...
    • Hutan
    • Thread
    • 2009 c1q complement exercise immunology lectin mannose-binding lectin mbl me/cfs paper pgk1
    • Replies: 2
    • Forum: ME/CFS research
  12. Hutan

    Complement activation in a model of chronic fatigue syndrome, 2003, Sorensen et al

    Published in 2003 https://www.jacionline.org/article/S0091-6749(03)01546-X/fulltext Abstract Background: A need exists to identify biological markers in chronic fatigue syndrome (CFS). Objective: To use an exercise and/or allergen challenge to induce the symptoms of CFS and to identify a...
    • Hutan
    • Thread
    • 2003 allergy c3a c4a c5a complement exercise immunology paper sorensen
    • Replies: 11
    • Forum: ME/CFS research
  13. Sly Saint

    Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping, 2021, Castro-Marrero et al

    Abstract Background: Routine blood analytics are systematically used in the clinic to diagnose disease or confirm individuals’ healthy status. For myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disease relying exclusively on clinical symptoms for its diagnosis, blood analytics...
    • Sly Saint
    • Thread
    • 2021 biomarker c1q castro-marrero complement diagnosis etiology immunology me/cfs oedema paper spain subgroups swelling vitamin d
    • Replies: 32
    • Forum: ME/CFS research
  14. Hutan

    Chronic fatigue syndrome and complement activation, 2009, Geller, Giclas

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028106/ Chronic fatigue syndrome and complement activation Robert Dennis Geller; Patricia C Giclas Abstract
    • Hutan
    • Thread
    • 2020 case report complement me/cfs paper
    • Replies: 4
    • Forum: ME/CFS research
  15. Saz94

    Research news from Bhupesh Prusty

  16. Andy

    Microparticles in the blood of patients with SLE [Lupus]: Size, content of mitochondria and role in circulating immune complexes, 2019, Mobarrez et al

    Paywall, https://www.sciencedirect.com/science/article/pii/S089684111930099X Sci hub, https://sci-hub.se/10.1016/j.jaut.2019.05.003
  17. Daisybell

    Complement levels - C3 and C4

    Has anyone had their complement levels tested? Is a low C3 relevant??? My C4 has come back at the bottom of the normal range, and my C3 is below the normal range.....
    • Daisybell
    • Thread
    • complement complement deficiency discussion thread
    • Replies: 20
    • Forum: Immunological
  18. M

    Exercise-induce hyperalgesia, complement system and elastase activation in ME/cfs - a secondary analysis (2018) Polli et al

    Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies Polli A1, Van Oosterwijck J2,3, Meeus M3,4, Lambrecht L5, Nijs J6, Ickmans K6. Author information 1 Pain in...
    • Milo
    • Thread
    • 2018 belgium complement exercise immunology me/cfs pain paper polli van oosterwijck
    • Replies: 2
    • Forum: ME/CFS research
  19. TrixieStix

    I was diagnosed with a rare autoimmune disease called "Relapsing Polychondritis"

    PART 1 Here is a run down of what's been going on with me.... In January of this year I traveled to see Dr. Chheda at Open Medicine Clinic. She had me try taking Ultra Low Dose Naltrexone, but I had a very bad reaction to it after just 1 dose and had to stop taking it immediately. She then had...
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