complement

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19 Sascha N. Goonewardena; Qinzhong Chen; Ashley M. Tate; Olga G. Grushko; Dilna Damodaran; Pennelope K. Blakely; Salim S. Hayek; David J. Pinsky; Robert S. Rosenson BACKGROUND SARS-CoV-2 infections...

Long COVID science, research and policy Al-Aly, Ziyad; Davis, Hannah; McCorkell, Lisa; Soares, Letícia; Wulf-Hanson, Sarah; Iwasaki, Akiko; Topol, Eric J. Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex...

Now published: linked here Preprint Abstract In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein monomers, with protofibrils and fibrils exhibiting a cross-beta motif of parallel or antiparallel beta-sheets oriented perpendicular to the fibre...

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius Published 16 July 2024 Abstract Myalgic...

Differential Gene Expression in the Upper Respiratory Tract following Acute COVID-19 Infection in Ambulatory Patients That Develop Long COVID Biondi, Mia J.; Addo, Mary; Zahoor, Muhammad Atif; Salvant, Elsa; Yip, Paul; Barber, Bethany; Smookler, David; Wasif, Sumaiyah; Gaete, Kayla; Kandel...

Abstract Hypermobile Ehlers-Danlos syndrome (hEDS) is a common heritable connective tissue disorder that lacks a known genetic etiology. To identify genetic contributions to hEDS, whole exome sequencing was performed on families and a cohort of sporadic hEDS patients. A missense variant in...

A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection Singh, Ankita; Adam, Awadalkareem; Aditi, ; Peng, Bi-Hung; Yu, Xiaoying; Zou, Jing; Kulkarni, Vikram V.; Kan, Peter; Jiang, Wei; Shi, Pei-Yong; Samir, Parimal; Cisneros, Irma; Wang, Tian Viral variant is...

Persistent Activation of Chronic Inflammatory Pathways in Long Covid Malika Aid; Katherine McMahan; Nicole Hachmann; Jessica Miller; Erica Borducchi; David Hope; Marjorie Rowe; Eleanor Schonberg; Siline Thai; Ai-ris Collier; Janet Mullington; Dan Barouch Long Covid, or Post-Acute Sequelae of...

Now published: Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect function of stem cell derived cardiomyocytes, 2024, Sinclair+']link here[/URL] Preprint Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of...

Role of the complement system in Long COVID Vadim Farztdinov; Boris Zuehlke; Franziska Sotzny; Fridolin Steinbeis; Martina Seifert; Claudia Kedor; Kirsten Wittke; Pinkus Tober-Lau; Kathrin Textoris-Taube; Daniela Ludwig; Clemens Dierks; Dominik Bierbaum; Leif Erik Sander; Leif Gunnar Hanitsch...

Sex differences in symptomatology and immune profiles of Long COVID Julio Silva; Takehiro Takahashi; Jamie Wood; Peiwen Lu; Sasha Tabachnikova; Jeffrey Gehlhausen; Kerrie Greene; Bornali Bhattacharjee; Valter Silva Monteiro; Carolina Lucas; Rahul Dhodapkar; Laura Tabacof; Mario Pena-Hernandez...

Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients Lekova, Eleonora; Zelek, Wioleta M.; Gower, David; Spitzfaden, Claus; Osuch, Isabelle H.; John-Morris, Elen; Stach, Lasse; Gormley, Darren; Sanderson...

Complement C7 and clusterin form a complex in circulation Massri, Mariam; Toonen, Erik J.M.; Sarg, Bettina; Kremser, Leopold; Grasse, Marco; Fleischer, Verena; Torres-Quesada, Omar; Hengst, Ludger; Skjoedt, Mikkel-Ole; Bayarri-Olmos, Rafael; Rosbjerg, Anne; Garred, Peter; Orth-Höller, Dorothea...

Complement in neurological disorders and emerging complement-targeted therapeutics Dalakas, Marinos C.; Alexopoulos, Harry; Spaeth, Peter J. The complement system consists of a network of plasma and membrane proteins that modulate tissue homeostasis and contribute to immune surveillance by...

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid Open access: https://www.science.org/doi/10.1126/science.adg7942 Editor’s summary Some individuals can endure persistent, debilitating symptoms for many months after an initial severe acute respiratory...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

Published abstract and link here Preprint Complement dysregulation is a predictive and therapeutically amenable feature of long COVID Background: Long COVID encompasses a heterogeneous set of ongoing symptoms that affect many individuals after recovery from infection with severe acute...

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19 Highlights Longitudinal proteomics reveals aberrant complement patterns in severe COVID-19 Human PSC-vascular organoid models endotheliopathy by SARS-CoV-2 infection SARS-CoV-2 spike-ECD triggers...

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Perico, Luca; Morigi, Marina; Pezzotta, Anna; Locatelli, Monica; Imberti, Barbara; Corna, Daniela; Cerullo, Domenico; Benigni, Ariela; Remuzzi, Giuseppe The...

Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease One in ten SARS-CoV-2 infections result in prolonged symptoms termed ‘long COVID’, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by...