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Successful treatment of POTS and MCAS using LDN, immunoglobulin and antibiotics

Discussion in 'ME/CFS research' started by adreno, May 13, 2018.

  1. adreno

    adreno Senior Member (Voting Rights)

    A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic and sustained response was documented. The utility of IVIg in autoimmune neuromuscular diseases has been published, but clinical experience with POTS is relatively unknown and has not been reported in MCAS. As a short-acting mu-opioid antagonist, LDN paradoxically increases endorphins which then bind to regulatory T cells which regulate T-lymphocyte and B-lymphocyte production and this reduces cytokine and antibody production. IVIg is emerging as a promising therapy for POTS. Diagnosis and treatment of SIBO in POTS is a new concept and appears to play an important role.

  2. Gingergrrl

    Gingergrrl Senior Member (Voting Rights)

    It will be in the future. IVIG is widely being used for POTS and MCAS but is just not published yet. It will be.
    ahimsa, Binkie4, MEMarge and 8 others like this.
  3. Andy

    Andy Committee Member

    Hampshire, UK

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