Persistent complement dysregulation with signs of thromboinflammation in active Long Covid, 2024, Boyman et al

[SNT Gatchaman]

In relation to serum clusterin —

Other proteins of the complement system, such as C3 desArg, C5a, clusterin, vitronectin, and the pentraxins CRP, pentraxin 3 (PTX3), and serum amyloid A4 measured by SomaScan, mass spectrometry, or ELISA were unchanged.

Compared with extracellular vesicles in ME/CFS: Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise (2024, Journal of Extracellular Vesicles) —

In our study, elevated CLU in EVs post-exercise is associated with worse myalgia, arthralgia, and fatigue indicating that this protein may have an important role in ME/CFS pathophysiology.

 

[V.R.T.]

https://www.cell.com/med/fulltext/S2666-6340(24)00041-2

A study at Cardiff university with similar findings (apparently not identical but my brain fog is terrible right now)

 

[SNT Gatchaman]

A study at Cardiff university with similar findings

Thread here.

 

[SNT Gatchaman]

See Role of the complement system in Long COVID (2024, Preprint: MedRxiv) which refutes these findings.