News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

ryanc97 said:
Think it's beyond doubt there is brain inflammation since patients all complain of the horrible inflammed head feeling, it's basically my worst symptom.
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It is unlikely that an inflamed feeling comes from inflammation in the head any more than a sugary taste comes from sugar in the head or a burning smell comes from burning in the head. The brain's job is to paint pictures that describe what is happening elsewhere. The components of the brain are, more or less, completely unaware of their own state. If you stick an electrode in an awake person's brain and fire electricity at it they may remember the house their grandmother lived in or see a green flash or anything pretty much except an electric shock.

There are parts of the brain that are there to pick up signs of inflammation elsewhere - just as eyes pick up sunlight on the grass. Those areas may actually use some of the same signals the inflamed tissues use. So for those areas to have some signals associated with inflammation in ME/CFS makes sense. But I don't see a scrap of evidence so far for inflammatory signals in other parts of brain. The only data we had was Nakatomi and it didn't really look like a pathological state because it had no specific pattern different from normals. It looked like the same pattern with the gain setting on the scan turned up a bit.

If Younger has specific patterns for glial activation in all the areas he talks of then that would be very interesting. But he didn't show a single picture of his own findings.
 
Jonathan Edwards said:
It is unlikely that an inflamed feeling comes from inflammation in the head any more than a sugary taste comes from sugar in the head or a burning smell comes from burning in the head. The brain's job is to paint pictures that describe what is happening elsewhere. The components of the brain are, more or less, completely unaware of their own state. If you stick an electrode in an awake person's brain and fire electricity at it they may remember the house their grandmother lived in or see a green flash or anything pretty much except an electric shock.

There are parts of the brain that are there to pick up signs of inflammation elsewhere - just as eyes pick up sunlight on the grass. Those areas may actually use some of the same signals the inflamed tissues use. So for those areas to have some signals associated with inflammation in ME/CFS makes sense. But I don't see a scrap of evidence so far for inflammatory signals in other parts of brain. The only data we had was Nakatomi and it didn't really look like a pathological state because it had no specific pattern different from normals. It looked like the same pattern with the gain setting on the scan turned up a bit.

If Younger has specific patterns for glial activation in all the areas he talks of then that would be very interesting. But he didn't show a single picture of his own findings.
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That's fair, I like that actually as it kind of aligns with my experience where when my blood pressure increases/pumps harder that 'inflamed' feeling goes away.

So it feels like an illusion, unless the coffee is actually dialing down whatever is causing the "inflamation"..
 
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ryanc97 said:
Isn't that in disagreement with Wirth/Scheibenbogen?
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Maybe dear old Ron is sensible enough to see that the minuscule difference between antibody levels in patients and controls in the Scheibenbogen study doesn't amount to 'specific elevated antibodies' in the books of any seasoned scientist.

And the study did not indicate specificity - patients and controls had antibodies to various things and there were no blinded controls testing for differences in antibodies to other things as far as I know.
 
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