News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

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wigglethemouse

Senior Member (Voting Rights)
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A couple of weeks ago he posted on the status of the papers he talked about at the Australia conference.
Neuroinflammation, Pain, and Fatigue Laboratory at UAB
Yes, I have one manuscript on that project almost finished. It hasn't been sent out yet because we turned our attention to getting out the dextromethorphan paper, as well as three papers on botanicals for pain and fatigue. Finishing the good day/bad day paper is next up. - Jarred Younger
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The dextromethorphan paper he refers too is a low dose treatment clinical trial for FM.
We have completed our clinical trial of low-dose dextromethorphan for fibromyalgia!

We ran a small clinical trial to test if low dose dextromethorphan could help reduce the symptoms of fibromyalgia (primarily widespread pain and fatigue). We have finished that study, written up the results, and submitted the paper for peer-review. Once it has completed the peer-review process and is approved for publication at a journal, I will share the results here. - Jarred Younger
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Post from 3rd Aug 2020 - exciting that he has a lot of treatment trials that may be relevant for ME/CFS
We have finished analyses for our ambitious study on botanical treatments for chronic pain and fatigue! Our group was the first to test nine different potential treatments in a single clinical trial of chronic pain and fatigue.

While we finished this project last year, the complex analyses and write-up took a good amount of additional time. We are now submitting the reports for publication, broken into three papers.

The first covers boswellia, curcumin, and french maritime pine bark.

The second reports on fisetin, luteolin, and resveratrol.

The third addresses reishi mushroom, stinging nettle, and epimedium.

This trial was conducted on individuals with Gulf War Illness, and I hope the results will be applicable to chronic fatigue syndrome and fibromyalgia as well (but that has to be tested). I will discuss the results as soon as I am able. - Jarred Younger
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Lisa108 said:
Here is a Youtube video from 2018, with Dr. Younger explaining a bit about the study and why/how low-dose dextromethorphan might work for treating fibromyalgia.
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Amw66 said:
Link ?
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I too have a real hard time seeing embedded links especially in short words. It would be great if someone could tweak the colour scheme to find a way to emphasise them better.
 
I havn´t watched the video or read the paper, so I don´t know what "low dose" exactly means here,
but in general I find low dose applications much better than normal ones.

I once tried Dextrometorphan (in normal dose) for my ME/CFS, but it worked only for one time very well.

But I want to emphasize once more low dose and even very low dose, this might actually be a key
(although I am talking in my case about rather special supps, and upon avoidances).

Hope, they get some clue anyway.
 
Jarred Younger is still recruiting and is looking for participants close to his lab in Birmingham Alabama. He doesn't say which particular study this. At a guess I would say this is his NIH brain imaging study.
[He along with a colleague also has an immune cell study https://www.s4me.info/threads/track...ing-zr-89-oxinate-4-labeled-leukocytes.11625/]
We are running brain imaging scans in people with ME/CFS.

We are still working to develop a brain scan for chronic fatigue syndrome (ME/CFS). If you are close to Birmingham, Alabama and are interested in undergoing this scan to help with our research, you can send an email to the project leader, Indonesia Jordan, at: ijordan@uab.edu

Participation requires one screening visit that involves blood tests, and one neuroimaging visit that will last less than one hour. Volunteers are compensated for their participation. The sessions take place at the University of Alabama at Birmingham. Feel free to pass this on to anyone who has chronic fatigue and lives around Birmingham.
Thanks!
- Jarred Younger
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I actually belive this guy 100%

My Brain is definetly inflamed

Whether that’s an overactive hypothalamus or something else I’m not sure but I’m fully behind this guy

Reason being I’ve managed to switch off the brain or inflammation a few times doing various things and the symptoms of m.e did actually go, sadly it was only temporarily but I believe this man is in the right track
 
Solve M.E. webinar, June 23: How We Can See ME/CFS Inflammation in the Brain

Dr. Jarred Younger’s 2016 Ramsay Award was used to show that brain temperature is elevated in ME/CFS. This increased temperature is a sign of brain inflammation. The findings are now being replicated in a large group of individuals with ME/CFS.

Dr. Younger’s lab is now developing new magnetic resonance imaging (MRI) and positron emission tomography (PET) scans that can determine whether someone is suffering from brain inflammation. The goal of this research is to conclusively show that brain inflammation should be made a primary target for ME/CFS treatment.

In this webinar, Dr. Younger will give updates on the brain inflammation research, describe the studies coming up, and discuss directions for improved ME/CFS treatment
 
Dr. Jarred Younger’s 2016 Ramsay Research Grant was used to show that brain temperature is elevated in ME/CFS. This increased temperature is a sign of brain inflammation. The findings are now being replicated in a large group of individuals with ME/CFS. Dr. Younger’s lab is now developing new magnetic resonance imaging (MRI) and positron emission tomography (PET) scans that can determine whether someone is suffering from brain inflammation. The goal of this research is to conclusively show that brain inflammation should be made a primary target for ME/CFS treatment. In this webinar, Dr. Younger will gave updates on the brain inflammation research, describe the studies coming up, and discuss directions for improved ME/CFS treatment.

 
I haven't watched the video yet, but surely this sentence in the blurb leaves out a vital word I've added in blue:

The goal of this research is to conclusively show that whether brain inflammation should be made a primary target for ME/CFS treatment.
 
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