News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

[Mij]

Jarred Younger’s low-dose naltrexone clinical trial for ME/CFS has been registered.

ClinicalTrials.gov

clinicaltrials.gov

 

[Yann04]

Don’t we already have an OMF + a MEA LDN study in the works.

Doses are interesting I think slightly higher than usually prescribed.

After the baseline period, participants will receive LDN capsules at one of four doses: 1.5mg/day, 3.0mg/day, 4.5mg/day, and 6.0mg/day in a blinded fashion.

 

[Mij]

Years ago I took the first dose listed - 1.5mg It was unpleasant and gave me terrible insomnia.

 

[ChronicallyOverIt]

Years ago I took the first dose listed - 1.5mg It was unpleasant and gave me terrible insomnia.

To be fair most people now start extremely small doses then work up to that. All the way to 4.5mg. That being said I had an unpleasant experience with it and didn’t help me one bit even titrating up small doses.

I thought Jared wanted to try a different form of the drug? He’s just doing regular old LDN? Why….

 

[ChronicallyOverIt]

All those videos just to land on the same drug that’s been tried a million times? The clinical trial says Low Dose naltrexone, not DEXTRO-Naltrexone??

 

[Yann04]

The clinical trial says Low Dose naltrexone, not DEXTRO-Naltrexone??

I was also under the impression that was what he was going to test. Perhaps both trials are in the works?

 

[ChronicallyOverIt]

If it’s truly not the former, dextro, I would argue that anyone that donated to this study was misled by the last video. Unless this is a different study. Looking forward to Jared clearing this up.

 

[Utsikt]

1 month baseline period, 8 months drug period.

No placebo control. Only blinding of participants.

PROMIS Fatigue Short Form 7a as primary outcome. No mention of other outcomes. Weekly measurements.

Because LDN might not be expected to show a dose response relationship, I think they need a placebo control. I’ve seen a few anecdotes of people saying they had no reaction at all to LDN, so unblinding from side effects might only be a partial issue. And you could always think you’ve just got too low of a dose if nothing happens.

 

[BrightCandle]

If it’s truly not the former, dextro, I would argue that anyone that donated to this study was misled by the last video

I swear he said he was setting up to a trial of dextro. I don't see the point of running another LDN trial from Dr Younger, we already have some on the go. The proposition of the dextro version however seemed more compelling and different to what others were doing.

 

[OrganicChilli]

I’ve seen a few anecdotes of people saying they had no reaction at all to LDN, so unblinding from side effects might only be a partial issue.

The best side effect I had were vivid dreams. I miss those lol.

If it’s truly not the former, dextro, I would argue that anyone that donated to this study got scammed?

Agreed. What's going on? Were people donating to a study or to get dextro manufactured? Or both? I don't recall.

 

[forestglip]

Didn't he just get funding for dextro a few weeks ago? Would have been really fast to have a protocol registered already, right? I assume that'll start after some time.

Seems like a good thing to have a dose-response study on LDN finally, even if unblinded.
(Edit: doses are blinded)