Not disputing the reality of what you say. But what's remarkable to me is that the medical community requires proof of mechanism and a biomarker to reverse a psychosomatic theory that they accepted without any valid scientific evidence to begin with. Per Dalen, a Swedish psychiatrist, noted that in the case of diagnoses like somatoform illness, there is a different standard of scientific proof used. He said, “Many doctors would never let themselves be caught with woolly ideas about the possible causes of cancer, multiple sclerosis, or cardiovascular diseases. But just mention the word somatization, and they will feel free to engage in uncritical speculation.” http://www.art-bin.com/art/dalen_en.html In the case of ME, IMO, there is substantial evidence for biopathophysiology in a number of systems and that should be enough to call into question the unfounded BPS theory even if you dont have proof for the ultimate cause or validated biomarkers.