A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

Barry said:
In the comments, this captures in a nutshell what excessive exercise can potentially do to pwME - pushing too hard past energy reserves, can shrink those reserves each time you do it, in a vicious downward spiral. Few words, big message.
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That has never been my experience. But then again, we are all different.
 
TigerLilea said:
That has never been my experience. But then again, we are all different.
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But how would you necessarily know? Many diseases start with such microscopic effects that build ever faster until they eventually become noticeable, and then intrusive, and then maybe worse. In the case of ME I was postulating that something similar might be happening, but the levelling off point for most pwME might be once they are aware enough to instigate a sensible pacing strategy, which then breaks the vicious circle by not then pushing past energy reserves, and so not shrinking them further.
 
two drugs identified !
they can deactivate "the thing" !

... should this be indeed the previously mentioned Elamipretide SS-31 and copaxone ?
anyone going to try copaxone ?

Esfandyarpour said “many” different drugs, inhibitors, enzymes, and substrates involved in cellular energy production have been tested to see if they can return ME/CFS samples to normal functioning in the nanoneedle. Two thus far (he didn’t say which ones) have returned the ME/CFS samples to normal functioning.
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https://www.omf.ngo/2019/05/07/health-rising-threading-the-needle-nanoneedle/

i believe, the two esfandyarpours could be brothers, perhaps
Davis-and-Rahim.jpg
 
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nanoneedle doesnt know MS or MECFS

definite MECFS = nanoneedle + RBC reduced deform (or brain scan to rule out MS damage)
Having some people with MS will test similarly to people with ME/CFS on the nanoneedle is not a deal breaker, though. Far from it. It’s not uncommon for diseases to share diagnostic markers. Doctors get around this by using a series of tests to diagnose patients. If some people with MS look like ME/CFS patients using the nanoneedle, then a brain scan which shows neuron damage in the M.S. patients will be able to differentiate the two diseases. People with MS and ME/CFS will be positive on both tests, while people with ME/CFS without MS will test positive only with the nanoneedle.

... problems with RBC deformity probably do not occur in MS, a positive nanoneedle and RBC deformability result should be enough to differentiate someone with ME/CFS from someone with MS or many other diseases.
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https://www.omf.ngo/2019/05/07/health-rising-threading-the-needle-nanoneedle/
 
roller* said:
... should this be indeed the previously mentioned Elamipretide SS-31 and copaxone ?
anyone going to try copaxone ?
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Here is an excerpt from Ron Davis's March 2019 Emerge Conference slide.
Davis_Copaxone_SS31.JPG

And this is the Ativan experiment using Seahorse from the same conference
Davis_SeahorseAtivan.JPG

So it looks like 3 drugs are of interest for trying to understand what effect they are having on various tests. I imagine these are one off tests, so it's a big jump to say they would work on all patients. In fact several people on various forums have reported trying 2 of the 3 drugs (I don't think SS-31 is on market yet) with mixed results.
 
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those who have side effects on copaxone may not be candidates for the nanoneedle-signal (as tested)
would be interesting, to see the nanoneedle signal-test for people with no/worsening effects after copaxone.

but, how great would that be to have a device and test in advance if copaxone will help. without damages caused, changes caused, and money spent.

ss31 may be too expensive for many out there.

.............

i misread the graph. ATIVAN doesnt necessarily "balance out" the impedence signal. it seems to increase mitochondrial respiration.
since ppl on both forums, for what i read, report only benefits for sleep from ativan. no more. (except for whitney dafoe)

so, there are only two (known) drugs to balance out impedence after salt.
 
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adambeyoncelowe said:
That's not quite what that article says. It says that if the nano-needle can't separate the two illnesses, additional tests might be needed. It doesn't specifically say that it can't distinguish between the two. That remains to be seen.
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And a bit lost in this that if this were a new cheap and reliable test for MS it would be huge news in itself and bring additional funding. An MS diagnosis is still a difficult task, often missed.

It's not going to light up from dozens of conditions, this kind of energy depletion is rare.
 
Don't think this has been posted (it's about this research):

Source: NIH Research Matters

Date: May 14, 2019

Author: Tianna Hicklin

URL:
https://www.nih.gov/news-events/nih...ic-encephalomyelitis/chronic-fatigue-syndrome

Blood test may detect myalgic encephalomyelitis/chronic fatigue syndrome
----------------------------------------------------------

At a Glance

* Researchers developed a blood test that, in a pilot study, accurately identified people with myalgic encephalomyelitis/chronic fatigue syndrome.

* If validated in larger studies, the assay could one day help diagnose the disease and enable researchers to test potential treatments.

More at link
 
Merged thread
I don't know if this has been posted already. Moderators, please delete if it has. I thought it noteworthy the NIH presented an article on this OMF research. There are other articles about this study already posted on this forum.

I like the term used in this article about one ME symptom, "extremely poor stamina".


https://www.nih.gov/news-events/nih...ic-encephalomyelitis/chronic-fatigue-syndrome
 
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Good job @DokaGirl for staying sharp. Still nice to see NIH taking credit for no effort. Scroll down to the botom of the page and you will understand what I meant.

Or perhaps I can make it easy for you (no need to thank me I am just looking out for my fellows).
Funding: NIH’s National Human Genome Research Institute (NHGRI) and the Open Medicine Foundation.
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@Dudden

Yep, noticed the funding bit. I think it's good though, that the NIH put this article out there - it hopefully gets more notice from mainstreamers. And yes, I agree, the people at the OMF have worked very hard, and been denied funding more than once by NIH. And now this institute is basking in the glory, so to speak. :banghead:
 
Here's my salute to Francis Collins who happily took credit for the research using the nanoneedle that found a blood marker for ME.

According to Janet Dafoe, "That NIH grant was TERMINATED about 2 years ago because NIH said they didn't want to fund that technology anymore. That grant had funded the initial development of the nanoneedle on cancer cells & bacteria. All the ME/CFS work started AFTER that & was FUNDED BY PATIENTS@OpenMedF"

When I heard that Collins had taken credit, I actually felt like I had been physically punched, given the fact that the NIH's failure to fund research has caused me and millions like me to suffer for decades.


NIH Takes Credit copy.jpeg
 
Well can they turn this around on NIH taking credit, since you are very proud of the nanoneedle we need "more" funding to further develop it. How about $10 million dollars?
No? But you "got" us this far, the media will give you even more good press if you "further" support our research.
 
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