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A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Apr 29, 2019.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    By Open Medicine Foundation

    full article here:
    https://www.sanluisobispo.com/news/state/california/article229756099.html

    [have looked at the link but can't find the published paper?]
    eta: link now works
    this one takes you to where it's listed
    https://www.pnas.org/search/chronic%2Bfatigue%2Bsyndrome content_type:journal

    eta2: paper here
    https://www.pnas.org/content/early/2019/04/24/1901274116

    Sci hub, https://sci-hub.se/10.1073/pnas.1901274116
     
    Last edited: Apr 30, 2019
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  2. Andy

    Andy Committee Member & Outreach

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    I would guess from this
    that that link will be updated later today at some point, with this and all other papers published today - it's still early morning US time.
     
  3. Alvin

    Alvin Senior Member (Voting Rights)

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    The biggest concern i have is is the small patient size.
    They need to verify this on a sample of thousands or tens of thousands before it should be considered a diagnostic test.
    Of course there are cost and logistical issues involved in doing this but if this test turns out to be wrong the damage done will be immense.
     
  4. Sunshine3

    Sunshine3 Senior Member (Voting Rights)

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    I wonder if it turns out to be right, how long will it take to get it approved. Has anyone any idea how long this kind of thing takes.. I know funding is a huge factor.
     
  5. Mij

    Mij Senior Member (Voting Rights)

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    It also has to be tested on other complex illnesses to see if it's unique to ME.

    Perhaps there are drugs that are already available.
     
  6. Aroa

    Aroa Established Member (Voting Rights)

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    It has to be tested on other illnesses where “fatigue” is one of the main simptoms.

    Even if it was a Test for PEM, it would be amazing. Time to apply for a NIH grant !!!
     
  7. Trish

    Trish Moderator Staff Member

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    I think it's a very good article - tells a patient's story, talks about what ME is and the fact that patients are often not believed, and a diagnostic test is desperately needed. Describes the nano needle test in simple terms, then spells out that much more research is needed before it can be made available - much bigger samples to verify, production of more kit, seeing if it distinguishes between ME and other chronic conditions and between severities of ME. They also say they are trying to raise funding for it.
     
  8. wdb

    wdb Senior Member (Voting Rights)

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    I'm going to hold off judgement until we know how significant the result was and how many parameters were measured in search of a significant looking one.
     
  9. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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    Excited to see this. PNAS is a high-impact journal and is of course multidisciplinary, which is an advantage.

    I worry with all the pressure on Ron and his team that they may try and rush things through. On the other hand, they are top-class scientists and know what they are doing.
     
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  10. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Is the article gone?
     
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  11. strategist

    strategist Senior Member (Voting Rights)

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    It's gone. They had a premature publication.
     
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  12. horizoncfs

    horizoncfs Established Member

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    The article is gone. I also can't find anything on National Academy of Sciences. I know Ron Davis said this piece was coming out soon but not sure what's going on. I'd love to share the headline far and wide!
     
  13. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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    As far as I can tell, and unless something else is going on, the paper is embargoed until 3 pm ET. I imagine the news article should have respected that embargo and that is the reason why it has disappeared.
     
  14. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    @InitialConditions

    I too worry about the pressure on the OMF, and Ron Davis. They are as you say top professionals. Another thing going for them is networking with other research groups. Hopefully that removes some of the pressure.
     
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  15. Kalliope

    Kalliope Senior Member (Voting Rights)

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  16. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Last edited: Apr 29, 2019
  17. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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  18. Andy

    Andy Committee Member & Outreach

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  19. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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  20. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    From Reuters. The second part seems irrelevant to me. Even if it's measuring a consequence of the illness, rather than its cause, it can still be a biomarker?

    ETA: It's SW commenting.
     

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