t-cells

  1. Jonathan Edwards

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Link to the thread on the preprint - 27 May 2025: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff ****** I am hoping that the paper I have been writing with Jo Cambridge and Jackie Cliff will appear on Qeios tomorrow. If...
  2. Sly Saint

    Scientists find early signs of T cell exhaustion in early infection stages

    Scientists find early signs of T cell exhaustion in early infection stages paper: Precursors of exhausted T cells are pre-emptively formed in acute infection | Nature
  3. E

    Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome, 2024, Iu, Hanson et al

    Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome Significance Myalgic encephalomyelitis/chronic fatigue syndrome (ME) is a serious disabling chronic illness that lacks FDA-approved therapies. Comprehensive...
    • EndME
    • Thread
    • cd8+ cornell university hanson t-cells
    • Replies: 41
    • Forum: ME/CFS research
  4. Wyva

    High prevalence of LC in anti-TPO positive euthyroid individuals with strongly elevated SARS-CoV-2-specific T cell responses (...), 2024, Matula et al

    Full title: High prevalence of long COVID in anti-TPO positive euthyroid individuals with strongly elevated SARS-CoV-2-specific T cell responses and moderately raised anti-spike IgG levels 23 months post-infection Zsolt Matula1 Viktória Király2 Gabriella Bekő2 Márton Gönczi2 András Zóka2 Róbert...
  5. Mij

    Soluble IL-2R impairs muscle cell mitochondrial respiration in fatigued individuals with post-acute sequelae of COVID-19, 2024, Peterson Brown

    Abstract Post-acute sequelae of COVID (PASC) persist in many patients for weeks and months after recovery from initial SARS-CoV-2 infection. Recent evidence suggests that pathological changes in skeletal muscle may contribute significantly to ongoing pain and fatigue, particularly...
    • Mij
    • Thread
    • cd25 il-2 il-2r jak-stat mitochondrial dysfunction muscle biopsy oxygen use seahorse t-cells
    • Replies: 10
    • Forum: Long Covid research
  6. SNT Gatchaman

    Trial Report COVID-19 related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac MRI abnormalities, 2024, Ćorović+

    COVID-19 related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac MRI abnormalities Ćorović, Andrej; Zhao, Xiaohui; Huang, Yuan; Newland, Stephen; Gopalan, Deepa; Harrison, James; Giakomidi, Despina; Chen, Shanna; Yarkoni, Natalia S; Wall...
  7. SNT Gatchaman

    Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus, 2024, Law et al.

    Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus Law, Calvin; Wacleche, Vanessa Sue; Cao, Ye; Pillai, Arundhati; Sowerby, John; Hancock, Brandon; Horisberger, Alice; Bracero, Sabrina; Skidanova, Viktoriya; Li, Zhihan; Adejoorin, Ifeoluwakiisi; Dillon, Eilish; Benque, Isaac...
  8. SNT Gatchaman

    Pituitary–Adrenal Axis and Peripheral Immune Cell Profile in Long COVID, 2024, Alijotas-Reig et al.

    Pituitary–Adrenal Axis and Peripheral Immune Cell Profile in Long COVID Alijotas-Reig, Jaume; Anunciacion-Llunell, Ariadna; Esteve-Valverde, Enrique; Morales-Pérez, Stephanie; Rivero-Santana, Sergio; Trapé, Jaume; González-García, Laura; Ruiz, Domingo; Marques-Soares, Joana; Miro-Mur, Francesc...
    • SNT Gatchaman
    • Thread
    • adrenal b-cells cortisol endocrine inflammation long covid neutrophils pituitary t-cells
    • Replies: 1
    • Forum: Long Covid research
  9. rvallee

    Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity, 2024, Ashkar et al

    Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity Nature, open access: https://www.nature.com/articles/s41467-023-44667-0 Abstract Although many viral infections are linked to the development of neurological disorders, the...
  10. rvallee

    Nature: ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission

    ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission https://www.nature.com/articles/d41586-023-03968-6 Engineered immune cells have given 15 people with once-debilitating autoimmune disorders a new lease on life, free from fresh symptoms or treatments. The results raise...
  11. SNT Gatchaman

    Review From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity, 2023, Müller and Di Benedetto

    From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity Müller, Ludmila; Di Benedetto, Svetlana The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. This mini-review...
  12. SNT Gatchaman

    The lung microbiome regulates brain autoimmunity, 2022, Hosang et al.

    The lung microbiome regulates brain autoimmunity Hosang, Leon; Canals, Roger Cugota; van der Flier, Felicia Joy; Hollensteiner, Jacqueline; Daniel, Rolf; Flügel, Alexander; Odoardi, Francesca Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune...
  13. Andy

    Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19 2023

    Abstract Purpose Post-acute sequelae of COVID-19 (PASC) affect approximately 10% of convalescent patients. The spectrum of symptoms is broad and heterogeneous with fatigue being the most often reported sequela. Easily accessible blood biomarkers to determine PASC severity are lacking. Thus, our...
  14. SNT Gatchaman

    Single-cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis-constituting cells, 2023, Shin et al.

    Single-cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis-constituting cells Sun Shin; Youn-Jee Chung; Seong Won Moon; Eun Ji Choi; Mee-Ran Kim; Yeun-Jun Chung; Sug Hyung Lee Endometriosis consists of ectopic endometrial epithelial cells...
  15. E

    Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation..., Hellemonds+

    Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity Background: Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling...
  16. SNT Gatchaman

    SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile, 2023, Zhang et al.

    SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile Zhang, Jia-Yuan; Whalley, Justin P.; Knight, Julian C.; Wicker, Linda S.; Todd, John A.; Ferreira, Ricardo C. The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in...
    • SNT Gatchaman
    • Thread
    • autoimmunity b-cells ecm extracellular matrix il-2 inflammation long covid monocytes nf-κb nk cells sars-cov-2 t-cells tnf
    • Replies: 1
    • Forum: Long Covid research
  17. SNT Gatchaman

    Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions, 2020, Fransen et al.

    Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions Fransen, Nina L; Hsiao, Cheng-Chih; van der Poel, Marlijn; Engelenburg, Hendrik J; Verdaasdonk, Kim; Vincenten, Maria C J; Remmerswaal, Ester B M; Kuhlmann, Tanja; Mason, Matthew R J; Hamann...
  18. SNT Gatchaman

    Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19, 2023, Peluso +

    Now published - link here ****** Preprint Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19 Michael J Peluso; Dylan M Ryder; Robert Flavell; Yingbing Wang; Jelena Levi; Brian H LaFranchi; Tyler-Marie M Deveau...
  19. SNT Gatchaman

    Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function, 2023, George et al.

    Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function Molly S. George; Jenifer Sanchez; Christina Rollings; David Fear; Peter Irving; Linda V. Sinclair; Anna Schurich Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T...
  20. SNT Gatchaman

    Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months, 2023, Santopaolo et al.

    Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months Marianna Santopaolo; Michaela Gregorova; Fergus Hamilton; David Arnold; Anna Long; Aurora Lacey; Alice Halliday; Holly Baum; Kristy Hamilton; Rachel Milligan; Elizabeth Oliver; Olivia...
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