rct

Moved from News from Cochrane https://iris.who.int/bitstream/handle/10665/378782/9789240097711-eng.pdf?sequence=1 page 8 The Technical Advisory Group (TAG) for Development of Best Practices for Clinical Trials was constituted through a public call for nominations. 16 names including Karla...

Now published - link here ******************** The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people...

Compelling evidence from meta-epidemiological studies demonstrates overestimation of effects in randomized trials that fail to optimize randomization and blind patients and outcome assessors [A number of authors are from Gordon Guyatt’s group at McMaster University in Canada] Objective To...

Many High-Quality Randomized Controlled Trials in Sports Physical Therapy Are Making False-Positive Claims of Treatment Effect: A Systematic Survey Chris Bleakley; Jonathan Reijgers; James M. Smoliga Objective To examine the risk of false-positive reporting within high-quality randomized...

Objective Our aim was to conduct a pilot randomized controlled trial of a novel cognitive behaviorally based intervention for pediatric PNES called Retraining and Control Therapy (ReACT). Methods Participants were randomized to receive either eight sessions of ReACT or supportive therapy, and...

Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown pathogenesis consisting of a variety of symptoms including severe fatigue. The objective of the study was to examine the efficacy and safety of a TLR-3 agonist, rintatolimod...

We have previously discussed interventions that manipulate how patients report symptoms as a separate form of bias, rather than as part of the placebo effect. Critics of the placebo effect have pointed out that according to the available evidence, "placebo effects are weak: regression to the...

Hopin Lee, PhD1,2; Aidan G. Cashin, PhD3,4; Sarah E. Lamb, DPhil1,5; Sally Hopewell, DPhil1; Stijn Vansteelandt, PhD6,7; Tyler J. VanderWeele, PhD8; David P. MacKinnon, PhD9; Gemma Mansell, PhD10; Gary S. Collins, PhD1,11; Robert M. Golub, MD12,13; James H. McAuley, PhD4,14; and the AGReMA...

https://www.miragenews.com/new-clinical-trial-aims-to-improve-diagnosis-597717/

First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People, 2021, MassBiologics, Phase I Study Type : Interventional (Clinical Trial) Estimated Enrollment : 48 participants Allocation: Randomized Intervention...

Given the rise in ACT 'research' this might be useful/of interest: https://contextualscience.org/act_randomized_controlled_trials_since_1986

The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement Christiaan H. Vinkers, Herm J. Lamberink, Joeri K. Tijdink, Pauline Heus, Lex Bouter, Paul Glasziou, David Moher, Johanna A. Damen...

Cognitive Behavioral Therapy Improves Physical Function and Fatigue in Mild and Moderate Chronic Fatigue Syndrome: A Consecutive Randomized Controlled Trial of Standard and Short Interventions Merethe Eide Gotaas, Tore C. Stiles, Johan Håkon Bjørngaard Petter C. Borchgrevink and Egil A. Fors...

Preprint Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial " Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and...

Background Despite evidence of selective outcome reporting across multiple disciplines, this has not yet been assessed in trials studying the effects of exercise in people with cancer. Therefore, the purpose of our study was to explore prospectively registered randomised controlled trials (RCTs)...

When is lack of scientific integrity a reason for retracting a paper? A case study. Abstract: This editorial has just come out in the Journal of Psychosomatic Research. It is a discussion of issues that arose from this 2004 publication: This study is a triple-blinded randomised controlled...

Paywall, https://www.jacc.org/doi/full/10.1016/j.jacc.2020.12.029

An SSRI to treat early COVID, supposedly SSRIs can inhibit SARS-CoV-2 and also potentially have anti-inflammatory and immunoregulatory properties. I think also earlier this year there was an observational study showing patients taking SSRIs had lower risk of severe COVID and death (I think a...

Thought it could be helpful to have a thread on Jonathan's expert testimony for any further use and citation. Edwards, Jonathan CW (2020), The difficulties of conducting intervention trials for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome: Expert testimony presented to...

https://www.jmir.org/2020/10/e17049/