neuroinflammation

Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis Bashir, Shah Tauseef; Redden, Catherine R.; Raj, Kishori; Arcanjo, Rachel B.; Stasiak, Sandra; Li, Quanxi; Steelman, Andrew J.; Nowak, Romana A. Chronic pelvic pain (CPP) is a common symptom of...

Abstract Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

Semi-automated Segmentation and Quantification of Perivascular Spaces at 7 Tesla in COVID-19 Langan MT, Smith DA, Verma G, Khegai O, Saju S, Rashid S, Ranti D, Markowitz M, Belani P, Jette N, Mathew B, Goldstein J, Kirsch CFE, Morris LS, Becker JH, Delman BN, Balchandani P While COVID-19 is...

Preprint See post 5 for published version Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals Elizabeth Griggs, Kyle Trageser, Sean Naughton, Eun-Jeong Yang, Brian Mathew, Grace Van Hyfte, Linh Hellmers, Nathalie Jette, Molly Estill, Li Shen, Tracy...

Published version linked in a later post ***** Preprint Choroid Plexus calcification correlates with cortical microglial activation in humans: a multimodal PET, CT, MRI study Tracy Butler, X. Hugh Wang, Gloria C. Chiang, Yi Li, Liangdong Zhou, Ke Xi, NimmiWickramasuriya, Emily Tanzi, Edward...

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study Etter MM, Martins TA, Kulsvehagen L, Pössnecker E, Duchemin W, Hogan S, Sanabria-Diaz G, Müller J, Chiappini A, Rychen J, Eberhard N, Guzman R, Mariani L...

[This seems to be only very tenuously about ME/CFS] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology and without effective treatment options. The onset of ME/CFS is often associated with neuroinflammation following bacterial or...

https://www.tandfonline.com/doi/abs/10.1080/03007995.2022.2096351 This study aimed to describe the neurological improvements in a patient with severe long COVID brain dysfunction following perispinal etanercept administration. Perispinal administration of etanercept, a novel method designed to...

Abstract Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer’s disease (AD). However, the mechanisms that link disruption of the blood–brain...

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Fuyuko Takata, Shinsuke Nakagawa, Junichi Matsumoto, Shinya Dohgu Neuroinflammation is...

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Preprint Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in...

Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET (Preprint) Denise Visser, Sandeep S.V. Golla, Sander C.J. Verfaillie, Emma M. Coomans, Roos M. Rikken, Elsmarieke M. van de Giessen, Marijke E. den Hollander, Anouk Verveen, Maqsood Yaqub, Frederik Barkhof...

Mapping microglia and astrocyte activation in vivo using diffusion MRI Raquel Garcia-Hernandez, Antonio Cerdán Cerdá, Alejandro Trouve Carpena, Mark Drakesmith, Kristin Koller, Derek K Jones, Santiago Canals, Silvia De Santis While glia are increasingly implicated in the pathophysiology of...

FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress Kai Kang, Pengfei Xu, Mengxia Wang, Jian Chunyu, Xu Sun, Guiping Ren, Wei Xiao, Deshan Li Previous studies indicate that FGF21 has ability to repair nerve injury, but the specific mechanism is less...

https://www.nature.com/articles/s41467-022-29657-y Abstract Blood-brain barrier (BBB) dysfunction is associated with worse epilepsy outcomes however the underlying molecular mechanisms of BBB dysfunction remain to be elucidated. Tight junction proteins are important regulators of BBB integrity...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...

Brief Summary: The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with...

Comer Ashley L., Carrier Micaël, Tremblay Marie-Ève, Cruz-Martín Alberto (2020), The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation, Frontiers in Cellular Neuroscience 14 (2020), DOI...

COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis Robyn Klein, Allison Soung, Cheick Sissoko, Anna Nordvig, Peter Canoll, Madeline Mariani, Xiaoping Jiang, Traci Bricker, James Goldman, Gorazd Rosoklija, Victoria Arango, Mark Underwood, John Mann, Adrianus Boon, Andrew...